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A2QL84 (BGALC_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable beta-galactosidase C

EC=3.2.1.23
Alternative name(s):
Lactase C
Gene names
Name:lacC
ORF Names:An06g00290
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length994 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans By similarity.

Catalytic activity

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 35 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Polysaccharide degradation
   Cellular componentSecreted
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpolysaccharide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionbeta-galactosidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 994975Probable beta-galactosidase C
PRO_5000220037

Sites

Active site1841Proton donor Potential
Active site2831Nucleophile Potential
Binding site781Substrate By similarity
Binding site1231Substrate By similarity
Binding site1241Substrate; via amide nitrogen By similarity
Binding site1251Substrate By similarity
Binding site1831Substrate By similarity
Binding site2471Substrate By similarity
Binding site3501Substrate By similarity

Amino acid modifications

Glycosylation881N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3881N-linked (GlcNAc...) Potential
Glycosylation4071N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation5001N-linked (GlcNAc...) Potential
Glycosylation5141N-linked (GlcNAc...) Potential
Glycosylation5211N-linked (GlcNAc...) Potential
Glycosylation5841N-linked (GlcNAc...) Potential
Glycosylation6001N-linked (GlcNAc...) Potential
Glycosylation6741N-linked (GlcNAc...) Potential
Glycosylation7121N-linked (GlcNAc...) Potential
Glycosylation7171N-linked (GlcNAc...) Potential
Glycosylation7571N-linked (GlcNAc...) Potential
Glycosylation8611N-linked (GlcNAc...) Potential
Glycosylation9691N-linked (GlcNAc...) Potential
Disulfide bond253 ↔ 301 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QL84 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 1B20B22277763D58

FASTA994108,643
        10         20         30         40         50         60 
MKLQSILSCW AILVAQIWAT TDGLTDLVAW DPYSLTVNGN RLFVYSGEFH YPRLPVPEMW 

        70         80         90        100        110        120 
LDVFQKMRAH GFNAVSLYFF WDYHSPINGT YDFETGAHNI QRLFDYAQEA GIYIIARAGP 

       130        140        150        160        170        180 
YCNAEFNGGG LALYLSDGSG GELRTSDATY HQAWTPWIER IGKIIADNSI TNGGPVILNQ 

       190        200        210        220        230        240 
IENELQETTH SASNTLVEYM EQIEEAFRAA GVDVPFTSNE KGQRSRSWST DYEDVGGAVN 

       250        260        270        280        290        300 
VYGLDSYPGG LSCTNPSTGF SVLRNYYQWF QNTSYTQPEY LPEFEGGWFS AWGADSFYDQ 

       310        320        330        340        350        360 
CTSELSPQFA DVYYKNNIGQ RVTLQNLYML YGGTNWGHLA APVVYTSYDY SAPLRETRQI 

       370        380        390        400        410        420 
RDKLSQTKLV GLFTRVSSGL LGVEMEGNGT SYTSTTSAYT WVLRNPNTTA GFYVVQQDTT 

       430        440        450        460        470        480 
SSQTDITFSL NVNTSAGAFT LPNINLQGRQ SKVISTDYPL GHSTLLYVST DIATYGTFGD 

       490        500        510        520        530        540 
TDVVVLYARS GQVVSFAFKN TTKLTFEEYG DSVNLTSSSG NRTITSYTYT QGSGTSVVKF 

       550        560        570        580        590        600 
SNGAIFYLVE TETAFRFWAP PTTTDPYVTA EQQIFVLGPY LVRNVSISGS VVDLVGDNDN 

       610        620        630        640        650        660 
ATTVEVFAGS PAKAVKWNGK EITVTKTDYG SLVGSIGGAD SSSITIPSLT GWKVRDSLPE 

       670        680        690        700        710        720 
IQSSYDDSKW TVCNKTTTLS PVDPLSLPVL FASDYGYYTG IKIYRGRFDG TNVTGANLTA 

       730        740        750        760        770        780 
QGGLAFGWNV WLNGDLVASL PGDADETSSN AAIDFSNHTL KQTDNLLTVV IDYTGHDETS 

       790        800        810        820        830        840 
TGDGVENPRG LLGATLNGGS FTSWKIQGNA GGAAGAYELD PVRAPMNEGG LLAERQGWHL 

       850        860        870        880        890        900 
PGYKAKSSDG WTDGSPLDGL NKSGVAFYLT TFTLDLPKKY DVPLGIQFTS PSTVDPVRIQ 

       910        920        930        940        950        960 
LFINGYQYGK YVPYLGPQTT FPIPPGIINN RDKNTIGLSL WAQTDAGAKL ENIELISYGA 

       970        980        990 
YESGFDAGNG TGFDLNGAKL GYQPEWTEAR AKYT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270108 Genomic DNA. Translation: CAK44945.1.

3D structure databases

ProteinModelPortalA2QL84.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00004935.

Protein family/group databases

CAZyGH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00005034; CADANGAP00004935; CADANGAG00005034.

Phylogenomic databases

eggNOGCOG1874.
HOGENOMHOG000181922.
OrthoDBEOG7ZGXBD.

Family and domain databases

Gene3D2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERPTHR23421. PTHR23421. 1 hit.
PfamPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSPR00742. GLHYDRLASE35.
SUPFAMSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBGALC_ASPNC
AccessionPrimary (citable) accession number: A2QL84
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries