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A2QL84

- BGALC_ASPNC

UniProt

A2QL84 - BGALC_ASPNC

Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei124 – 1241Substrate; via amide nitrogenBy similarity
    Binding sitei125 – 1251SubstrateBy similarity
    Binding sitei183 – 1831SubstrateBy similarity
    Active sitei184 – 1841Proton donorSequence Analysis
    Binding sitei247 – 2471SubstrateBy similarity
    Active sitei283 – 2831NucleophileSequence Analysis
    Binding sitei350 – 3501SubstrateBy similarity

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. polysaccharide catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Keywords - Biological processi

    Carbohydrate metabolism, Polysaccharide degradation

    Protein family/group databases

    CAZyiGH35. Glycoside Hydrolase Family 35.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable beta-galactosidase C (EC:3.2.1.23)
    Alternative name(s):
    Lactase C
    Gene namesi
    Name:lacC
    ORF Names:An06g00290
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 8ER

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 994975Probable beta-galactosidase CPRO_5000220037Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi253 ↔ 301By similarity
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi712 – 7121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi717 – 7171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi861 – 8611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00004935.

    Structurei

    3D structure databases

    ProteinModelPortaliA2QL84.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 35 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1874.
    HOGENOMiHOG000181922.
    OrthoDBiEOG7ZGXBD.

    Family and domain databases

    Gene3Di2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProiIPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PANTHERiPTHR23421. PTHR23421. 1 hit.
    PfamiPF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view]
    PRINTSiPR00742. GLHYDRLASE35.
    SUPFAMiSSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    A2QL84-1 [UniParc]FASTAAdd to Basket

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    MKLQSILSCW AILVAQIWAT TDGLTDLVAW DPYSLTVNGN RLFVYSGEFH    50
    YPRLPVPEMW LDVFQKMRAH GFNAVSLYFF WDYHSPINGT YDFETGAHNI 100
    QRLFDYAQEA GIYIIARAGP YCNAEFNGGG LALYLSDGSG GELRTSDATY 150
    HQAWTPWIER IGKIIADNSI TNGGPVILNQ IENELQETTH SASNTLVEYM 200
    EQIEEAFRAA GVDVPFTSNE KGQRSRSWST DYEDVGGAVN VYGLDSYPGG 250
    LSCTNPSTGF SVLRNYYQWF QNTSYTQPEY LPEFEGGWFS AWGADSFYDQ 300
    CTSELSPQFA DVYYKNNIGQ RVTLQNLYML YGGTNWGHLA APVVYTSYDY 350
    SAPLRETRQI RDKLSQTKLV GLFTRVSSGL LGVEMEGNGT SYTSTTSAYT 400
    WVLRNPNTTA GFYVVQQDTT SSQTDITFSL NVNTSAGAFT LPNINLQGRQ 450
    SKVISTDYPL GHSTLLYVST DIATYGTFGD TDVVVLYARS GQVVSFAFKN 500
    TTKLTFEEYG DSVNLTSSSG NRTITSYTYT QGSGTSVVKF SNGAIFYLVE 550
    TETAFRFWAP PTTTDPYVTA EQQIFVLGPY LVRNVSISGS VVDLVGDNDN 600
    ATTVEVFAGS PAKAVKWNGK EITVTKTDYG SLVGSIGGAD SSSITIPSLT 650
    GWKVRDSLPE IQSSYDDSKW TVCNKTTTLS PVDPLSLPVL FASDYGYYTG 700
    IKIYRGRFDG TNVTGANLTA QGGLAFGWNV WLNGDLVASL PGDADETSSN 750
    AAIDFSNHTL KQTDNLLTVV IDYTGHDETS TGDGVENPRG LLGATLNGGS 800
    FTSWKIQGNA GGAAGAYELD PVRAPMNEGG LLAERQGWHL PGYKAKSSDG 850
    WTDGSPLDGL NKSGVAFYLT TFTLDLPKKY DVPLGIQFTS PSTVDPVRIQ 900
    LFINGYQYGK YVPYLGPQTT FPIPPGIINN RDKNTIGLSL WAQTDAGAKL 950
    ENIELISYGA YESGFDAGNG TGFDLNGAKL GYQPEWTEAR AKYT 994
    Length:994
    Mass (Da):108,643
    Last modified:March 6, 2007 - v1
    Checksum:i1B20B22277763D58
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270108 Genomic DNA. Translation: CAK44945.1.

    Genome annotation databases

    EnsemblFungiiCADANGAT00005034; CADANGAP00004935; CADANGAG00005034.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270108 Genomic DNA. Translation: CAK44945.1 .

    3D structure databases

    ProteinModelPortali A2QL84.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00004935.

    Protein family/group databases

    CAZyi GH35. Glycoside Hydrolase Family 35.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANGAT00005034 ; CADANGAP00004935 ; CADANGAG00005034 .

    Phylogenomic databases

    eggNOGi COG1874.
    HOGENOMi HOG000181922.
    OrthoDBi EOG7ZGXBD.

    Family and domain databases

    Gene3Di 2.102.20.10. 1 hit.
    2.60.120.260. 2 hits.
    2.60.390.10. 1 hit.
    3.20.20.80. 1 hit.
    InterProi IPR018954. Betagal_dom2.
    IPR025972. BetaGal_dom3.
    IPR025300. BetaGal_jelly_roll_dom.
    IPR008979. Galactose-bd-like.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR001944. Glycoside_Hdrlase_35.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    PANTHERi PTHR23421. PTHR23421. 1 hit.
    Pfami PF10435. BetaGal_dom2. 1 hit.
    PF13363. BetaGal_dom3. 1 hit.
    PF13364. BetaGal_dom4_5. 2 hits.
    PF01301. Glyco_hydro_35. 1 hit.
    [Graphical view ]
    PRINTSi PR00742. GLHYDRLASE35.
    SUPFAMi SSF117100. SSF117100. 1 hit.
    SSF49785. SSF49785. 2 hits.
    SSF51445. SSF51445. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiBGALC_ASPNC
    AccessioniPrimary (citable) accession number: A2QL84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3