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A2QL84

- BGALC_ASPNC

UniProt

A2QL84 - BGALC_ASPNC

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Protein

Probable beta-galactosidase C

Gene

lacC

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans.By similarity

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei78 – 781SubstrateBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei124 – 1241Substrate; via amide nitrogenBy similarity
Binding sitei125 – 1251SubstrateBy similarity
Binding sitei183 – 1831SubstrateBy similarity
Active sitei184 – 1841Proton donorSequence Analysis
Binding sitei247 – 2471SubstrateBy similarity
Active sitei283 – 2831NucleophileSequence Analysis
Binding sitei350 – 3501SubstrateBy similarity

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC

GO - Biological processi

  1. polysaccharide catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Polysaccharide degradation

Protein family/group databases

CAZyiGH35. Glycoside Hydrolase Family 35.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable beta-galactosidase C (EC:3.2.1.23)
Alternative name(s):
Lactase C
Gene namesi
Name:lacC
ORF Names:An06g00290
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 8ER

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 994975Probable beta-galactosidase CPRO_5000220037Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi253 ↔ 301By similarity
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi388 – 3881N-linked (GlcNAc...)Sequence Analysis
Glycosylationi407 – 4071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi500 – 5001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi514 – 5141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi521 – 5211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi584 – 5841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi674 – 6741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi712 – 7121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi717 – 7171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi757 – 7571N-linked (GlcNAc...)Sequence Analysis
Glycosylationi861 – 8611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi969 – 9691N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00004935.

Structurei

3D structure databases

ProteinModelPortaliA2QL84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 35 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1874.
HOGENOMiHOG000181922.
OrthoDBiEOG7ZGXBD.

Family and domain databases

Gene3Di2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProiIPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR23421. PTHR23421. 1 hit.
PfamiPF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view]
PRINTSiPR00742. GLHYDRLASE35.
SUPFAMiSSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2QL84-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLQSILSCW AILVAQIWAT TDGLTDLVAW DPYSLTVNGN RLFVYSGEFH
60 70 80 90 100
YPRLPVPEMW LDVFQKMRAH GFNAVSLYFF WDYHSPINGT YDFETGAHNI
110 120 130 140 150
QRLFDYAQEA GIYIIARAGP YCNAEFNGGG LALYLSDGSG GELRTSDATY
160 170 180 190 200
HQAWTPWIER IGKIIADNSI TNGGPVILNQ IENELQETTH SASNTLVEYM
210 220 230 240 250
EQIEEAFRAA GVDVPFTSNE KGQRSRSWST DYEDVGGAVN VYGLDSYPGG
260 270 280 290 300
LSCTNPSTGF SVLRNYYQWF QNTSYTQPEY LPEFEGGWFS AWGADSFYDQ
310 320 330 340 350
CTSELSPQFA DVYYKNNIGQ RVTLQNLYML YGGTNWGHLA APVVYTSYDY
360 370 380 390 400
SAPLRETRQI RDKLSQTKLV GLFTRVSSGL LGVEMEGNGT SYTSTTSAYT
410 420 430 440 450
WVLRNPNTTA GFYVVQQDTT SSQTDITFSL NVNTSAGAFT LPNINLQGRQ
460 470 480 490 500
SKVISTDYPL GHSTLLYVST DIATYGTFGD TDVVVLYARS GQVVSFAFKN
510 520 530 540 550
TTKLTFEEYG DSVNLTSSSG NRTITSYTYT QGSGTSVVKF SNGAIFYLVE
560 570 580 590 600
TETAFRFWAP PTTTDPYVTA EQQIFVLGPY LVRNVSISGS VVDLVGDNDN
610 620 630 640 650
ATTVEVFAGS PAKAVKWNGK EITVTKTDYG SLVGSIGGAD SSSITIPSLT
660 670 680 690 700
GWKVRDSLPE IQSSYDDSKW TVCNKTTTLS PVDPLSLPVL FASDYGYYTG
710 720 730 740 750
IKIYRGRFDG TNVTGANLTA QGGLAFGWNV WLNGDLVASL PGDADETSSN
760 770 780 790 800
AAIDFSNHTL KQTDNLLTVV IDYTGHDETS TGDGVENPRG LLGATLNGGS
810 820 830 840 850
FTSWKIQGNA GGAAGAYELD PVRAPMNEGG LLAERQGWHL PGYKAKSSDG
860 870 880 890 900
WTDGSPLDGL NKSGVAFYLT TFTLDLPKKY DVPLGIQFTS PSTVDPVRIQ
910 920 930 940 950
LFINGYQYGK YVPYLGPQTT FPIPPGIINN RDKNTIGLSL WAQTDAGAKL
960 970 980 990
ENIELISYGA YESGFDAGNG TGFDLNGAKL GYQPEWTEAR AKYT
Length:994
Mass (Da):108,643
Last modified:March 6, 2007 - v1
Checksum:i1B20B22277763D58
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270108 Genomic DNA. Translation: CAK44945.1.

Genome annotation databases

EnsemblFungiiCADANGAT00005034; CADANGAP00004935; CADANGAG00005034.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270108 Genomic DNA. Translation: CAK44945.1 .

3D structure databases

ProteinModelPortali A2QL84.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00004935.

Protein family/group databases

CAZyi GH35. Glycoside Hydrolase Family 35.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00005034 ; CADANGAP00004935 ; CADANGAG00005034 .

Phylogenomic databases

eggNOGi COG1874.
HOGENOMi HOG000181922.
OrthoDBi EOG7ZGXBD.

Family and domain databases

Gene3Di 2.102.20.10. 1 hit.
2.60.120.260. 2 hits.
2.60.390.10. 1 hit.
3.20.20.80. 1 hit.
InterProi IPR018954. Betagal_dom2.
IPR025972. BetaGal_dom3.
IPR025300. BetaGal_jelly_roll_dom.
IPR008979. Galactose-bd-like.
IPR013781. Glyco_hydro_catalytic_dom.
IPR001944. Glycoside_Hdrlase_35.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR23421. PTHR23421. 1 hit.
Pfami PF10435. BetaGal_dom2. 1 hit.
PF13363. BetaGal_dom3. 1 hit.
PF13364. BetaGal_dom4_5. 2 hits.
PF01301. Glyco_hydro_35. 1 hit.
[Graphical view ]
PRINTSi PR00742. GLHYDRLASE35.
SUPFAMi SSF117100. SSF117100. 1 hit.
SSF49785. SSF49785. 2 hits.
SSF51445. SSF51445. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiBGALC_ASPNC
AccessioniPrimary (citable) accession number: A2QL84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3