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A2QL72 (AGALA_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable alpha-galactosidase A

EC=3.2.1.22
Alternative name(s):
Melibiase A
Gene names
Name:aglA
ORF Names:An06g00170
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length537 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides By similarity.

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.

Subcellular location

Secreted By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 27 family.

Contains 1 ricin B-type lectin domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 537514Probable alpha-galactosidase A
PRO_5000220032

Regions

Domain413 – 537125Ricin B-type lectin

Sites

Active site1541Nucleophile By similarity
Active site2121Proton donor By similarity

Amino acid modifications

Glycosylation491N-linked (GlcNAc...) Potential
Glycosylation871N-linked (GlcNAc...) Potential
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential
Glycosylation2031N-linked (GlcNAc...) Potential
Glycosylation3551N-linked (GlcNAc...) Potential
Glycosylation4361N-linked (GlcNAc...) Potential
Glycosylation4911N-linked (GlcNAc...) Potential
Disulfide bond46 ↔ 78 By similarity
Disulfide bond126 ↔ 156 By similarity
Disulfide bond430 ↔ 444 By similarity
Disulfide bond469 ↔ 482 By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QL72 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: F093FD8196C7F839

FASTA53759,213
        10         20         30         40         50         60 
MNQGTKSILL AATLAAIPWQ VYGSIEQSSL LPIPPMGFNN WARFMCDLNE TLFTETADAM 

        70         80         90        100        110        120 
AANGLRDAGY NRINLDDCWM AYQRSDNGSL QWNTTKFPHG LPWLAQYVKA KGFHFGIYED 

       130        140        150        160        170        180 
SGNMTCGGYP GSYNHEEQDA NTFALWGIDY LKLDGCNVYA TQGRTLEEEY KQRYGHWHQV 

       190        200        210        220        230        240 
LSKMQHPLIF SESAPAYFAG TDNNTDWYTV MDWVPIYGEL ARHSTDILVY SGAGSAWDSI 

       250        260        270        280        290        300 
MNNYNYNTLL ARYQRPGYFN DPDFLIPDHP GLTADEKRSH FALWASFSAP LIISAYIPAL 

       310        320        330        340        350        360 
SKDEIAFLTN EALIAVNQDP LAQQATFASR DNTLDILTRN LANGDRLLTV LNKGNTTVTR 

       370        380        390        400        410        420 
DIPVQWLGLT ETDCTYTAED LWDGKTQKIS DHIKIELASH ATAVFRLGLP QGCSSVVPTG 

       430        440        450        460        470        480 
LVFNTASGNC LTAASNSSVA FQSCNGETSQ IWQVTLSGVI RPVSQTTQCL AADGNSVKLQ 

       490        500        510        520        530 
ACDSTDSDGQ NWTYAVTGNL KNAKTDGCLT EGSVQMKSCL YERDGQVFGL PSGVQLS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270108 Genomic DNA. Translation: CAK44933.1.
RefSeqXP_001390845.1. XM_001390808.1.

3D structure databases

ProteinModelPortalA2QL72.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00004923.

Protein family/group databases

CAZyCBM13. Carbohydrate-Binding Module Family 13.
GH27. Glycoside Hydrolase Family 27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00005022; CADANGAP00004923; CADANGAG00005022.
GeneID4981013.
KEGGang:ANI_1_6054.

Phylogenomic databases

HOGENOMHOG000161224.
KOK07407.
OrthoDBEOG7SR4WK.

Family and domain databases

Gene3D2.60.40.1180. 1 hit.
3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR013780. Glyco_hydro_13_b.
IPR002241. Glyco_hydro_27.
IPR000111. Glyco_hydro_GHD.
IPR017853. Glycoside_hydrolase_SF.
IPR000772. Ricin_B_lectin.
[Graphical view]
PfamPF02065. Melibiase. 1 hit.
PF00652. Ricin_B_lectin. 1 hit.
[Graphical view]
PRINTSPR00740. GLHYDRLASE27.
SMARTSM00458. RICIN. 1 hit.
[Graphical view]
SUPFAMSSF50370. SSF50370. 1 hit.
SSF51445. SSF51445. 1 hit.
PROSITEPS00512. ALPHA_GALACTOSIDASE. 1 hit.
PS50231. RICIN_B_LECTIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAGALA_ASPNC
AccessionPrimary (citable) accession number: A2QL72
Entry history
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries