ID   PRTT_ASPNC              Reviewed;         623 AA.
AC   A2QJF9;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   27-MAR-2024, entry version 85.
DE   RecName: Full=Transcriptional activator of proteases prtT;
DE   AltName: Full=Zn(2)-C6 zinc finger-containing protein prtT;
GN   Name=prtT; ORFNames=An04g06940;
OS   Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=425011;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4892 / CBS 513.88 / FGSC A1513;
RX   PubMed=17259976; DOI=10.1038/nbt1282;
RA   Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J.,
RA   Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R.,
RA   Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X.,
RA   Contreras R., Cornell M., Coutinho P.M., Danchin E.G.J., Debets A.J.M.,
RA   Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M.,
RA   d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J.,
RA   Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W.,
RA   van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M.,
RA   Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X.,
RA   van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A.,
RA   Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E.,
RA   Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J.,
RA   Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H.,
RA   Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.;
RT   "Genome sequencing and analysis of the versatile cell factory Aspergillus
RT   niger CBS 513.88.";
RL   Nat. Biotechnol. 25:221-231(2007).
RN   [2]
RP   FUNCTION.
RX   PubMed=18930158; DOI=10.1016/j.fgb.2008.09.007;
RA   Punt P.J., Schuren F.H., Lehmbeck J., Christensen T., Hjort C.,
RA   van den Hondel C.A.;
RT   "Characterization of the Aspergillus niger prtT, a unique regulator of
RT   extracellular protease encoding genes.";
RL   Fungal Genet. Biol. 45:1591-1599(2008).
CC   -!- FUNCTION: Transcription factor required for protein utilization and
CC       degradation. Regulates transcription of major secreted proteases.
CC       {ECO:0000269|PubMed:18930158}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- SIMILARITY: Belongs to the prtT family. {ECO:0000305}.
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DR   EMBL; AM270080; CAK44694.1; -; Genomic_DNA.
DR   RefSeq; XP_001402055.1; XM_001402018.2.
DR   AlphaFoldDB; A2QJF9; -.
DR   EnsemblFungi; CAK44694; CAK44694; An04g06940.
DR   GeneID; 4991098; -.
DR   KEGG; ang:An04g06940; -.
DR   VEuPathDB; FungiDB:An04g06940; -.
DR   HOGENOM; CLU_030102_0_0_1; -.
DR   OrthoDB; 2100713at2759; -.
DR   Proteomes; UP000006706; Chromosome 6L.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IMP:UniProtKB.
DR   GO; GO:0042176; P:regulation of protein catabolic process; IMP:UniProtKB.
DR   CDD; cd12148; fungal_TF_MHR; 1.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; Zn(2)-C6 fungal-type DNA-binding domain; 1.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   InterPro; IPR001138; Zn2Cys6_DnaBD.
DR   PANTHER; PTHR31845; FINGER DOMAIN PROTEIN, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR31845:SF34; TRANSCRIPTIONAL ACTIVATOR OF PROTEASES PRTT; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; Zn2/Cys6 DNA-binding domain; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..623
FT                   /note="Transcriptional activator of proteases prtT"
FT                   /id="PRO_0000407033"
FT   DNA_BIND        50..79
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   623 AA;  70224 MW;  CE107CEBC798514E CRC64;
     MTRTVDEIKY ETPSSWEHKS LDVAEDGRRL APHSDTARPK GRIRRSMTAC HTCRKLKTRC
     DLDPRGHACR RCLSLRIDCK LPETTDRFQD SAAMWPDATS AIPSIEERLT SLERCMREMT
     GMMRQMLDHS PGFANASVPH LTKSIITDEN ASMEGSPSSP FLPKPVRLIQ DLQSDFFGEA
     ETSPVDSPLS SDGNAKGAID SKLSLKLLQT FVDHFGACVS IYNLSDIHND MKAPDSLLYN
     TACLLASRYV PGIPTSTVHA IYLQVRHAVV NILWEKPPLK YETLQALALL CLWPATAQKE
     PPMDSWLLSG ISINHAIIAL DFLNYAPSEV MVDNETAAQL RLWNTYCLTQ LHFAVGNARP
     FHIQQRYLDH CPRILEHPAA TLEDARVVAE IQLYLMTLRL QSNSSRMRLA DLDYEEIERW
     KREWAHLFSG ESSTLELSLW FCQTLLHRTA MRLQPRSDRL ASEVLQTSRL IISRFLQIRY
     STALSLVDQV YFIVGYAALN LCDFNLMDPL IEQVQMFLLH LSPNEDHIAY RFSCMVAEFK
     RRCGSAECND PSSTVKGSPL SSYGDSRKMS MGQAPFMPPL MDGMIEGYGF EQLMPEVMPS
     SFPDGILNGM PVTGLAAYRS ATL
//