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A2QJF9

- PRTT_ASPNC

UniProt

A2QJF9 - PRTT_ASPNC

Protein

Transcriptional activator of proteases prtT

Gene

prtT

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 50 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Transcription factor required for protein utilization and degradation. Regulates transcription of major secreted proteases.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi50 – 7930Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB
    2. regulation of protein catabolic process Source: UniProtKB

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional activator of proteases prtT
    Alternative name(s):
    Zn(2)-C6 zinc finger-containing protein prtT
    Gene namesi
    Name:prtT
    ORF Names:An04g06940
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 6L

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 623623Transcriptional activator of proteases prtTPRO_0000407033Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00004310.

    Structurei

    3D structure databases

    ProteinModelPortaliA2QJF9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the prtT family.Curated
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG81463.
    HOGENOMiHOG000190417.
    OrthoDBiEOG75MW59.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    PfamiPF00172. Zn_clus. 1 hit.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2QJF9-1 [UniParc]FASTAAdd to Basket

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    MTRTVDEIKY ETPSSWEHKS LDVAEDGRRL APHSDTARPK GRIRRSMTAC    50
    HTCRKLKTRC DLDPRGHACR RCLSLRIDCK LPETTDRFQD SAAMWPDATS 100
    AIPSIEERLT SLERCMREMT GMMRQMLDHS PGFANASVPH LTKSIITDEN 150
    ASMEGSPSSP FLPKPVRLIQ DLQSDFFGEA ETSPVDSPLS SDGNAKGAID 200
    SKLSLKLLQT FVDHFGACVS IYNLSDIHND MKAPDSLLYN TACLLASRYV 250
    PGIPTSTVHA IYLQVRHAVV NILWEKPPLK YETLQALALL CLWPATAQKE 300
    PPMDSWLLSG ISINHAIIAL DFLNYAPSEV MVDNETAAQL RLWNTYCLTQ 350
    LHFAVGNARP FHIQQRYLDH CPRILEHPAA TLEDARVVAE IQLYLMTLRL 400
    QSNSSRMRLA DLDYEEIERW KREWAHLFSG ESSTLELSLW FCQTLLHRTA 450
    MRLQPRSDRL ASEVLQTSRL IISRFLQIRY STALSLVDQV YFIVGYAALN 500
    LCDFNLMDPL IEQVQMFLLH LSPNEDHIAY RFSCMVAEFK RRCGSAECND 550
    PSSTVKGSPL SSYGDSRKMS MGQAPFMPPL MDGMIEGYGF EQLMPEVMPS 600
    SFPDGILNGM PVTGLAAYRS ATL 623
    Length:623
    Mass (Da):70,224
    Last modified:March 6, 2007 - v1
    Checksum:iCE107CEBC798514E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270080 Genomic DNA. Translation: CAK44694.1.
    RefSeqiXP_001402055.1. XM_001402018.2.

    Genome annotation databases

    EnsemblFungiiCADANGAT00004405; CADANGAP00004310; CADANGAG00004405.
    GeneIDi4991098.
    KEGGiang:ANI_1_1102184.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270080 Genomic DNA. Translation: CAK44694.1 .
    RefSeqi XP_001402055.1. XM_001402018.2.

    3D structure databases

    ProteinModelPortali A2QJF9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00004310.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANGAT00004405 ; CADANGAP00004310 ; CADANGAG00004405 .
    GeneIDi 4991098.
    KEGGi ang:ANI_1_1102184.

    Phylogenomic databases

    eggNOGi NOG81463.
    HOGENOMi HOG000190417.
    OrthoDBi EOG75MW59.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    Pfami PF00172. Zn_clus. 1 hit.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
    PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.
    2. "Characterization of the Aspergillus niger prtT, a unique regulator of extracellular protease encoding genes."
      Punt P.J., Schuren F.H., Lehmbeck J., Christensen T., Hjort C., van den Hondel C.A.
      Fungal Genet. Biol. 45:1591-1599(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPRTT_ASPNC
    AccessioniPrimary (citable) accession number: A2QJF9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 50 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3