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A2QJF9

- PRTT_ASPNC

UniProt

A2QJF9 - PRTT_ASPNC

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Protein

Transcriptional activator of proteases prtT

Gene

prtT

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Transcription factor required for protein utilization and degradation. Regulates transcription of major secreted proteases.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi50 – 7930Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. positive regulation of transcription, DNA-templated Source: UniProtKB
  2. regulation of protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional activator of proteases prtT
Alternative name(s):
Zn(2)-C6 zinc finger-containing protein prtT
Gene namesi
Name:prtT
ORF Names:An04g06940
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 6L

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 623623Transcriptional activator of proteases prtTPRO_0000407033Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00004310.

Structurei

3D structure databases

ProteinModelPortaliA2QJF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the prtT family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG81463.
HOGENOMiHOG000190417.
OrthoDBiEOG75MW59.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
PfamiPF00172. Zn_clus. 1 hit.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2QJF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTRTVDEIKY ETPSSWEHKS LDVAEDGRRL APHSDTARPK GRIRRSMTAC
60 70 80 90 100
HTCRKLKTRC DLDPRGHACR RCLSLRIDCK LPETTDRFQD SAAMWPDATS
110 120 130 140 150
AIPSIEERLT SLERCMREMT GMMRQMLDHS PGFANASVPH LTKSIITDEN
160 170 180 190 200
ASMEGSPSSP FLPKPVRLIQ DLQSDFFGEA ETSPVDSPLS SDGNAKGAID
210 220 230 240 250
SKLSLKLLQT FVDHFGACVS IYNLSDIHND MKAPDSLLYN TACLLASRYV
260 270 280 290 300
PGIPTSTVHA IYLQVRHAVV NILWEKPPLK YETLQALALL CLWPATAQKE
310 320 330 340 350
PPMDSWLLSG ISINHAIIAL DFLNYAPSEV MVDNETAAQL RLWNTYCLTQ
360 370 380 390 400
LHFAVGNARP FHIQQRYLDH CPRILEHPAA TLEDARVVAE IQLYLMTLRL
410 420 430 440 450
QSNSSRMRLA DLDYEEIERW KREWAHLFSG ESSTLELSLW FCQTLLHRTA
460 470 480 490 500
MRLQPRSDRL ASEVLQTSRL IISRFLQIRY STALSLVDQV YFIVGYAALN
510 520 530 540 550
LCDFNLMDPL IEQVQMFLLH LSPNEDHIAY RFSCMVAEFK RRCGSAECND
560 570 580 590 600
PSSTVKGSPL SSYGDSRKMS MGQAPFMPPL MDGMIEGYGF EQLMPEVMPS
610 620
SFPDGILNGM PVTGLAAYRS ATL
Length:623
Mass (Da):70,224
Last modified:March 6, 2007 - v1
Checksum:iCE107CEBC798514E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270080 Genomic DNA. Translation: CAK44694.1.
RefSeqiXP_001402055.1. XM_001402018.2.

Genome annotation databases

EnsemblFungiiCADANGAT00004405; CADANGAP00004310; CADANGAG00004405.
GeneIDi4991098.
KEGGiang:ANI_1_1102184.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270080 Genomic DNA. Translation: CAK44694.1 .
RefSeqi XP_001402055.1. XM_001402018.2.

3D structure databases

ProteinModelPortali A2QJF9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00004310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00004405 ; CADANGAP00004310 ; CADANGAG00004405 .
GeneIDi 4991098.
KEGGi ang:ANI_1_1102184.

Phylogenomic databases

eggNOGi NOG81463.
HOGENOMi HOG000190417.
OrthoDBi EOG75MW59.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
Pfami PF00172. Zn_clus. 1 hit.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS00463. ZN2_CY6_FUNGAL_1. 1 hit.
PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.
  2. "Characterization of the Aspergillus niger prtT, a unique regulator of extracellular protease encoding genes."
    Punt P.J., Schuren F.H., Lehmbeck J., Christensen T., Hjort C., van den Hondel C.A.
    Fungal Genet. Biol. 45:1591-1599(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPRTT_ASPNC
AccessioniPrimary (citable) accession number: A2QJF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3