A2QIL5 (ATG1_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase atg1
EC=2.7.11.1

Alternative name(s):
Autophagy-related protein 1

Gene names

Name:	atg1
ORF Names:	An04g03950

Organism

Aspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]

Taxonomic identifier

425011 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus

Protein attributes

Sequence length	1007 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serine/threonine protein kinase probably involved in the cytoplasm to vacuole transport (Cvt) and in autophagy, where it may be required for the formation of autophagosomes By similarity.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Biological process	Autophagy Protein transport Transport
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	autophagy Inferred from electronic annotation. Source: UniProtKB-KW protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1007	1007	Serine/threonine-protein kinase atg1		PRO_0000317788
Regions
	Domain	30 – 336	307	Protein kinase
	Nucleotide binding	36 – 44	9	ATP By similarity
Sites
	Active site	174	1	Proton acceptor By similarity
	Binding site	59	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2QIL5 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: D15EEE57D480DAFD	FASTA	1,007	108,897
	10 20 30 40 50 60 MGLFHHSTLF LPLLRRSNEG PHGEMPIGHY TRLSEIGRGS FAVVYKGVHT RSRTYVAIKS 70 80 90 100 110 120 VTMTKLSRKL KENLASEISI LKQLHHPHIV ALLDCHDTTS NIHLVMEFCA LGDLSHFIKG 130 140 150 160 170 180 RNTLQDSPYT RELIAKYPNP GEGAGLNEVI VRHFLKQLSS ALRFLRDRDL IHRDIKPQNL 190 200 210 220 230 240 LLCPAPSSYR SGAADVVPFK SSEDSFSPKT GLESLPMLKL ADFGFARSLP ATSLAETLCG 250 260 270 280 290 300 SPLYMAPEIL RYEKYDAKAD LWSVGTVLYE MVVGRAPFRA VNHIELIKKI EQNKDQISFP 310 320 330 340 350 360 SKNRVSEDIR ELIRGLLKQH PMDRMNFDVY FAHKVLTEPI PGLVADDAPL GRSPADPTPR 370 380 390 400 410 420 PGSGSRRSTP VQMKRENALS GGVRDEPATY PAAQRAMTQS PRPETPSTPM RRTGSAGTPH 430 440 450 460 470 480 AAPNEPTPPA SHPTRPSPVS LATAPGRQEH VDRPPTTTVV EQQRRRTASS GVPQVDKPVE 490 500 510 520 530 540 KAKDEKEHAA QEVAFERDYV LVEKRAVEMN AFADELAYNP RMQGGQAGAV SRRSGAAPGT 550 560 570 580 590 600 PPAGGSSPHA SPSKAMQIIS GRSRADSAHV RQNSYDRRYG QSPTSATSAI SKALNMASGR 610 620 630 640 650 660 LFGMSFSPPL TITKGGRSPP LAYNPFPAYP SAQTSLIVHA DGGKPGANLD EDSKTVHDLE 670 680 690 700 710 720 ECATRSDVVY GFAEVKYKQL IPLAPSAATG YPGDPGSDAV DSADGGLTVD AIVTLSEEAL 730 740 750 760 770 780 VLYVKALSLL AKSMDIARVW WTRKSRGDTL SRADTGSTVA GNRINNVVQW VRNRFNEVLE 790 800 810 820 830 840 KAEFVRLKLV EAQKRLPSDH PSHPSNLSVG SSLGSGTSAD VVVSPDVTAE KLMYERALEM 850 860 870 880 890 900 SRVAAINEIT GEDLAGCEIS YVTAIRMLEA ILDDVEVSRP GQSGGADRAD ARRDNEDGGQ 910 920 930 940 950 960 NEPQAVILAK SANAWHSDIE NPESPGVAPE EAGAAVESVH APVQWTGQNA AVESGASLPC 970 980 990 1000 SGSHAAEIRT LTVRSMQDHA HFAPLLFSIF ISSYSSSISC PSSCGHC

References

[1]

"Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88." Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M. , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H. Nat. Biotechnol. 25:221-231(2007) [PubMed: 17259976] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBS 513.88 / FGSC A1513.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM270075 Genomic DNA. Translation: CAK38659.1.
3D structure databases
ProteinModelPortal	A2QIL5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANGAT00004108; CADANGAP00004016; CADANGAG00004108.
GenomeReviews	Gene locus atg1 in contig AM270983_GR.
Phylogenomic databases
GeneTree	EFGT00050000000597.
HOGENOM	HBG324852.
OrthoDB	EOG43XZCK.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_kinase-like_dom. IPR008271. Ser/Thr_kinase_AS. IPR022708. Ser/Thr_kinase_C. IPR002290. Ser/Thr_kinase_dom. [Graphical view]
Pfam	PF12063. DUF3543. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ATG1_ASPNC

Accession

Primary (citable) accession number: A2QIL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	March 6, 2007
Last modified:	September 21, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program