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A2QGA1 (M2DH_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol 2-dehydrogenase

Short name=M2DH
Short name=MDH
EC=1.1.1.67
Gene names
ORF Names:An03g02430
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activity

D-mannitol + NAD+ = D-fructose + NADH.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol 2-dehydrogenase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Mannitol 2-dehydrogenase
PRO_0000371541

Regions

Nucleotide binding37 – 4812NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A2QGA1 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 47DE72CE48497048

FASTA48854,803
        10         20         30         40         50         60 
MGPLKLNTAN LSQIVAAGAG RVKVPTYRRG PALKEGIVHV GVGGFHRAHL AVYVDQLMQN 

        70         80         90        100        110        120 
HGVTDYAICG VGLQPFDSAM RDALSSQDNL YTVIERSAKG SFANVIGSIN SYLFAPDDRE 

       130        140        150        160        170        180 
AVIAKMAHPD TRIVSLTITE SGYYYNENTH ELQSEHPDIQ FDLDPANEKT PRTTFGFLYA 

       190        200        210        220        230        240 
ALARRHQQEE WFHHPSHARV FRPSPHPEVA QWITDKGAFP NAMVDRITPQ TSPADKESLA 

       250        260        270        280        290        300 
NTMGIEDSWP VVTEPFMQWV IEDQFSDGRP PFEKVGVQVV KDVHAVEEFE KHKLRLLNGS 

       310        320        330        340        350        360 
HSAIGYPGQM AGFNYVHEVL ENPDFNKFVW QMMQEEVKPS LPEIPGVDID QYCKTLMERF 

       370        380        390        400        410        420 
SNPTIMDQLP RICLNASGKI PQFIMPSIAE AIWVKGPLRR LCFVAAAWFR YINGVDDQGN 

       430        440        450        460        470        480 
TFTVDDPMRE ELQAKARAGG TKPSELLSIT SLFGDDLRND KRFMQEITNA MEDIARDGIL 


KTLPKYID 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM270048 Genomic DNA. Translation: CAK38211.1.

3D structure databases

ProteinModelPortalA2QGA1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00003184.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiCADANGAT00003266; CADANGAP00003184; CADANGAG00003266.

Phylogenomic databases

eggNOGCOG0246.
HOGENOMHOG000202982.
OrthoDBEOG7PCJRT.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 2 hits.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. SSF48179. 1 hit.
ProtoNetSearch...

Entry information

Entry nameM2DH_ASPNC
AccessionPrimary (citable) accession number: A2QGA1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 6, 2007
Last modified: November 13, 2013
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families