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A2QGA1

- M2DH_ASPNC

UniProt

A2QGA1 - M2DH_ASPNC

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Protein
Mannitol 2-dehydrogenase
Gene
An03g02430
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway By similarity.

Catalytic activityi

D-mannitol + NAD+ = D-fructose + NADH.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi37 – 4812NAD By similarity
Add
BLAST

GO - Molecular functioni

  1. coenzyme binding Source: InterPro
  2. mannitol 2-dehydrogenase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mannitol 2-dehydrogenase (EC:1.1.1.67)
    Short name:
    M2DH
    Short name:
    MDH
    Gene namesi
    ORF Names:An03g02430
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 6R

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Mannitol 2-dehydrogenase
    PRO_0000371541Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer By similarity.

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00003184.

    Structurei

    3D structure databases

    ProteinModelPortaliA2QGA1.

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0246.
    HOGENOMiHOG000202982.
    OrthoDBiEOG7PCJRT.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view]
    PRINTSiPR00084. MTLDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2QGA1-1 [UniParc]FASTAAdd to Basket

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    MGPLKLNTAN LSQIVAAGAG RVKVPTYRRG PALKEGIVHV GVGGFHRAHL    50
    AVYVDQLMQN HGVTDYAICG VGLQPFDSAM RDALSSQDNL YTVIERSAKG 100
    SFANVIGSIN SYLFAPDDRE AVIAKMAHPD TRIVSLTITE SGYYYNENTH 150
    ELQSEHPDIQ FDLDPANEKT PRTTFGFLYA ALARRHQQEE WFHHPSHARV 200
    FRPSPHPEVA QWITDKGAFP NAMVDRITPQ TSPADKESLA NTMGIEDSWP 250
    VVTEPFMQWV IEDQFSDGRP PFEKVGVQVV KDVHAVEEFE KHKLRLLNGS 300
    HSAIGYPGQM AGFNYVHEVL ENPDFNKFVW QMMQEEVKPS LPEIPGVDID 350
    QYCKTLMERF SNPTIMDQLP RICLNASGKI PQFIMPSIAE AIWVKGPLRR 400
    LCFVAAAWFR YINGVDDQGN TFTVDDPMRE ELQAKARAGG TKPSELLSIT 450
    SLFGDDLRND KRFMQEITNA MEDIARDGIL KTLPKYID 488
    Length:488
    Mass (Da):54,803
    Last modified:March 6, 2007 - v1
    Checksum:i47DE72CE48497048
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270048 Genomic DNA. Translation: CAK38211.1.

    Genome annotation databases

    EnsemblFungiiCADANGAT00003266; CADANGAP00003184; CADANGAG00003266.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270048 Genomic DNA. Translation: CAK38211.1 .

    3D structure databases

    ProteinModelPortali A2QGA1.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00003184.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANGAT00003266 ; CADANGAP00003184 ; CADANGAG00003266 .

    Phylogenomic databases

    eggNOGi COG0246.
    HOGENOMi HOG000202982.
    OrthoDBi EOG7PCJRT.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 2 hits.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR000669. Mannitol_DH.
    IPR013118. Mannitol_DH_C.
    IPR013131. Mannitol_DH_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01232. Mannitol_dh. 1 hit.
    PF08125. Mannitol_dh_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00084. MTLDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiM2DH_ASPNC
    AccessioniPrimary (citable) accession number: A2QGA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 5, 2009
    Last sequence update: March 6, 2007
    Last modified: November 13, 2013
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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