A2QFV9 (AXHA_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable alpha-L-arabinofuranosidase axhA
EC=3.2.1.55

Alternative name(s):
Arabinoxylan arabinofuranohydrolase axhA

Gene names

Name:	axhA
ORF Names:	An03g00960

Organism

Aspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]

Taxonomic identifier

425011 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Pezizomycotina › leotiomyceta › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Trichocomaceae › mitosporic Trichocomaceae › Aspergillus › Aspergillus niger

Protein attributes

Sequence length	332 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan By similarity.
Catalytic activity	Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the glycosyl hydrolase 62 family.

Ontologies

Keywords
Biological process	Xylan degradation
Cellular component	Secreted
Domain	Signal
Molecular function	Glycosidase Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	L-arabinose metabolic process Inferred from electronic annotation. Source: InterPro xylan catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	alpha-N-arabinofuranosidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 332	306	Probable alpha-L-arabinofuranosidase axhA		PRO_5000219727

Sequences

	Sequence		Length	Mass (Da)
	A2QFV9 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: F6EEE44EB8C43FEB	FASTA	332	35,837
	10 20 30 40 50 60 MKFLKAKGSL LSSGIYLIAL APFVNAKCAL PSTYSWTSTD ALATPKSGWT ALKDFTDVVS 70 80 90 100 110 120 NGKHIVYAST TDTQGNYGSM GFGAFSDWSD MASASQTATS FSAVAPTLFY FQPKSIWVLA 130 140 150 160 170 180 YQWGSSTFTY RTSQDPTNVN GWSSEQALFT GKISGSSTGA IDQTVIGDDT NMYLFFAGDN 190 200 210 220 230 240 GKIYRSSMSI NDFPGSFGSQ YEEILSGATN DLFEAVQVYT VDGGEGDSKY LMIVEAIGST 250 260 270 280 290 300 GHRYFRSFTA SSLGGEWTAQ AASEDQPFAG KANSGATWTD DISHGDLVRN NPDQTMTVDP 310 320 330 CNLQLLYQGH DPNSNSDYNL LPWKPGVLTL KQ

References

[1]

"Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88." Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M. , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H. Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CBS 513.88 / FGSC A1513.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AM270045 Genomic DNA. Translation: CAK38069.1.
RefSeq	XP_001389998.1. XM_001389961.2.
3D structure databases
ProteinModelPortal	A2QFV9.
ModBase	Search...
Protein-protein interaction databases
STRING	5061.CADANGAP00003042.
Protein family/group databases
CAZy	GH62. Glycoside Hydrolase Family 62.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	CADANGAT00003121; CADANGAP00003042; CADANGAG00003121.
GeneID	4980084.
KEGG	ang:ANI_1_108034.
Phylogenomic databases
HOGENOM	HOG000164911.
KO	K01209.
OrthoDB	EOG4XH383.
Family and domain databases
InterPro	IPR005193. GH62_arabinosidase. IPR023296. Glyco_hydro_beta-prop. [Graphical view]
Pfam	PF03664. Glyco_hydro_62. 1 hit. [Graphical view]
SUPFAM	SSF75005. Glyco_hydro_43_beta-prop. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AXHA_ASPNC

Accession

Primary (citable) accession number: A2QFV9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 20, 2010
Last sequence update:	March 6, 2007
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program