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A2QFG8

- ACUK_ASPNC

UniProt

A2QFG8 - ACUK_ASPNC

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Protein

Transcription activator of gluconeogenesis acuK

Gene

acuK

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi71 – 9929Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Gluconeogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription activator of gluconeogenesis acuK
Gene namesi
Name:acuK
ORF Names:AN7468
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 4R

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 686686Transcription activator of gluconeogenesis acuKPRO_0000406433Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00002901.

Family & Domainsi

Sequence similaritiesi

Belongs to the ERT1/acuK family.Curated
Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG39365.
HOGENOMiHOG000162694.
OrthoDBiEOG70KGZB.

Family and domain databases

Gene3Di4.10.240.10. 1 hit.
InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view]
SMARTiSM00066. GAL4. 1 hit.
[Graphical view]
SUPFAMiSSF57701. SSF57701. 1 hit.
PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2QFG8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNAEPKEQDS PAPSAERTEA SQEISAAGAQ ADKPKTEANG DGTANGASAN
60 70 80 90 100
GQKPNPKDPS RPRRKKARRA CFACQRAHLT CGDERPCQRC IKRGLQDACH
110 120 130 140 150
DGVRKKAKYL HDAPDGALMP GIGGTFYNNP MRNSLPLSRN GANAVNATGQ
160 170 180 190 200
QSAGANFYPT PQSTTYVYQE NTINQGSFPS QSPVSPTFNL KATPTARTNS
210 220 230 240 250
LSSVNPQPPS TSVSGPPGQG QNPFAGPFFD PSDPALFNFD LSSMNFENRY
260 270 280 290 300
GALEFGMLGH MATGAGDSPS DSATQRGSMG RSGSAQYAST PITGAPGFGE
310 320 330 340 350
SPGNQQPFMF GDPLLNEWPS GQAPGQPHLP GVYPQSGQGS AIPGHLSKAD
360 370 380 390 400
APHAFAIESG PASFNSPGAT TSPQMTTGLE ETPFHSAVAS KSNGLAPHGQ
410 420 430 440 450
RPMITTPSLK HQNLQVGVRR RQRNPSAIYD SVKEPYAYTS RFHGLTAFIQ
460 470 480 490 500
RRFPPQKTLQ IAKALASIRP SFIATTKTLN RDDLIFMEKC FQRTLWEYED
510 520 530 540 550
FINACGTPTI VCRRTGEIAA VGKEFSILTG WKKDVLLGKE PNLNVNTGGS
560 570 580 590 600
SMPNSGASSR SFTPRSTVDN TPGRPQPVFL AELLDDDSVV QFYEDFARLA
610 620 630 640 650
FGDSRGSVMT TCKLLKYKTK EDMEGAAAED SQRWNNHLRK GGIASEAGMN
660 670 680
QLGFKDGKVE CAYCWTVKRD VFDIPMLIVM NFLPCI
Length:686
Mass (Da):73,793
Last modified:March 6, 2007 - v1
Checksum:iBD6E9362737D5F81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270040 Genomic DNA. Translation: CAK48879.1.
RefSeqiXP_001400579.1. XM_001400542.2.

Genome annotation databases

EnsemblFungiiCADANGAT00002975; CADANGAP00002901; CADANGAG00002975.
GeneIDi4979989.
KEGGiang:ANI_1_1998024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270040 Genomic DNA. Translation: CAK48879.1 .
RefSeqi XP_001400579.1. XM_001400542.2.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00002901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00002975 ; CADANGAP00002901 ; CADANGAG00002975 .
GeneIDi 4979989.
KEGGi ang:ANI_1_1998024.

Phylogenomic databases

eggNOGi NOG39365.
HOGENOMi HOG000162694.
OrthoDBi EOG70KGZB.

Family and domain databases

Gene3Di 4.10.240.10. 1 hit.
InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
[Graphical view ]
SMARTi SM00066. GAL4. 1 hit.
[Graphical view ]
SUPFAMi SSF57701. SSF57701. 1 hit.
PROSITEi PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiACUK_ASPNC
AccessioniPrimary (citable) accession number: A2QFG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 5, 2011
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3