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A2QFG8

- ACUK_ASPNC

UniProt

A2QFG8 - ACUK_ASPNC

Protein

Transcription activator of gluconeogenesis acuK

Gene

acuK

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi71 – 9929Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding RNA polymerase II transcription factor activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. gluconeogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Gluconeogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription activator of gluconeogenesis acuK
    Gene namesi
    Name:acuK
    ORF Names:AN7468
    OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
    Taxonomic identifieri425011 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
    ProteomesiUP000006706: Chromosome 4R

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 686686Transcription activator of gluconeogenesis acuKPRO_0000406433Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5061.CADANGAP00002901.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ERT1/acuK family.Curated
    Contains 1 Zn(2)-C6 fungal-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG39365.
    HOGENOMiHOG000162694.
    OrthoDBiEOG70KGZB.

    Family and domain databases

    Gene3Di4.10.240.10. 1 hit.
    InterProiIPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view]
    SMARTiSM00066. GAL4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57701. SSF57701. 1 hit.
    PROSITEiPS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2QFG8-1 [UniParc]FASTAAdd to Basket

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    MNAEPKEQDS PAPSAERTEA SQEISAAGAQ ADKPKTEANG DGTANGASAN    50
    GQKPNPKDPS RPRRKKARRA CFACQRAHLT CGDERPCQRC IKRGLQDACH 100
    DGVRKKAKYL HDAPDGALMP GIGGTFYNNP MRNSLPLSRN GANAVNATGQ 150
    QSAGANFYPT PQSTTYVYQE NTINQGSFPS QSPVSPTFNL KATPTARTNS 200
    LSSVNPQPPS TSVSGPPGQG QNPFAGPFFD PSDPALFNFD LSSMNFENRY 250
    GALEFGMLGH MATGAGDSPS DSATQRGSMG RSGSAQYAST PITGAPGFGE 300
    SPGNQQPFMF GDPLLNEWPS GQAPGQPHLP GVYPQSGQGS AIPGHLSKAD 350
    APHAFAIESG PASFNSPGAT TSPQMTTGLE ETPFHSAVAS KSNGLAPHGQ 400
    RPMITTPSLK HQNLQVGVRR RQRNPSAIYD SVKEPYAYTS RFHGLTAFIQ 450
    RRFPPQKTLQ IAKALASIRP SFIATTKTLN RDDLIFMEKC FQRTLWEYED 500
    FINACGTPTI VCRRTGEIAA VGKEFSILTG WKKDVLLGKE PNLNVNTGGS 550
    SMPNSGASSR SFTPRSTVDN TPGRPQPVFL AELLDDDSVV QFYEDFARLA 600
    FGDSRGSVMT TCKLLKYKTK EDMEGAAAED SQRWNNHLRK GGIASEAGMN 650
    QLGFKDGKVE CAYCWTVKRD VFDIPMLIVM NFLPCI 686
    Length:686
    Mass (Da):73,793
    Last modified:March 6, 2007 - v1
    Checksum:iBD6E9362737D5F81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270040 Genomic DNA. Translation: CAK48879.1.
    RefSeqiXP_001400579.1. XM_001400542.2.

    Genome annotation databases

    EnsemblFungiiCADANGAT00002975; CADANGAP00002901; CADANGAG00002975.
    GeneIDi4979989.
    KEGGiang:ANI_1_1998024.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AM270040 Genomic DNA. Translation: CAK48879.1 .
    RefSeqi XP_001400579.1. XM_001400542.2.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5061.CADANGAP00002901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii CADANGAT00002975 ; CADANGAP00002901 ; CADANGAG00002975 .
    GeneIDi 4979989.
    KEGGi ang:ANI_1_1998024.

    Phylogenomic databases

    eggNOGi NOG39365.
    HOGENOMi HOG000162694.
    OrthoDBi EOG70KGZB.

    Family and domain databases

    Gene3Di 4.10.240.10. 1 hit.
    InterProi IPR001138. Zn2-C6_fun-type_DNA-bd.
    [Graphical view ]
    SMARTi SM00066. GAL4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57701. SSF57701. 1 hit.
    PROSITEi PS50048. ZN2_CY6_FUNGAL_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
      Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
      , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
      Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: CBS 513.88 / FGSC A1513.

    Entry informationi

    Entry nameiACUK_ASPNC
    AccessioniPrimary (citable) accession number: A2QFG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 5, 2011
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3