Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hexokinase

Gene

hxk

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: ASPGD

GO - Biological processi

  1. carbohydrate phosphorylation Source: GOC
  2. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:hxkImported
ORF Names:An02g14380Imported
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)Imported
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706 Componenti: Chromosome 4R

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00002891.

Structurei

3D structure databases

ProteinModelPortaliA2QFF8.
SMRiA2QFF8. Positions 18-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000162670.
KOiK00844.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2QFF8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGIGPKRPP SRKGSMADVP QNLLQQIKDF EDQFTVDRSK LKQIVNHFVK
60 70 80 90 100
ELEKGLSVEG GNIPMNVTWV LGFPDGDEQG TFLALDMGGT NLRVCEITLT
110 120 130 140 150
QEKGAFDITQ SKYRMPEELK TGTAEELWEY IADCLQQFIE SHHENEKISK
160 170 180 190 200
LPLGFTFSYP ATQDYIDHGV LQRWTKGFDI DGVEGHDVVP PLEAILQKRG
210 220 230 240 250
LPIKVAALIN DTTGTLIASS YTDSDMKIGC IFGTGVNAAY MENAGSIPKL
260 270 280 290 300
AHMNLPADMP VAINCEYGAF DNEHIVLPLT KYDHIIDRDS PRPGQQAFEK
310 320 330 340 350
MTAGLYLGEI FRLALMDLVE NRPGLIFNGQ DTTKLRKPYI LDASFLAAIE
360 370 380 390 400
EDPYENLEET EELMERELNI KATPAELEMI RRLAELIGTR AARLSACGVA
410 420 430 440 450
AICTKKKIDS CHVGADGSVF TKYPHFKARG AKALREILDW APEEQDKVTI
460 470 480 490
MAAEDGSGVG AALIAALTLK RVKAGNLAGI RNMADMKTLL
Length:490
Mass (Da):54,090
Last modified:September 22, 2008 - v1
Checksum:i9DA489EA7768651B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270040 Genomic DNA. Translation: CAK48869.1.
RefSeqiXP_001400569.1. XM_001400532.2.

Genome annotation databases

EnsemblFungiiCADANGAT00002964; CADANGAP00002891; CADANGAG00002964.
GeneIDi4979978.
KEGGiang:ANI_1_1984024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM270040 Genomic DNA. Translation: CAK48869.1.
RefSeqiXP_001400569.1. XM_001400532.2.

3D structure databases

ProteinModelPortaliA2QFF8.
SMRiA2QFF8. Positions 18-481.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5061.CADANGAP00002891.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCADANGAT00002964; CADANGAP00002891; CADANGAG00002964.
GeneIDi4979978.
KEGGiang:ANI_1_1984024.

Phylogenomic databases

HOGENOMiHOG000162670.
KOiK00844.
OrthoDBiEOG79SF68.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513Imported.

Entry informationi

Entry nameiA2QFF8_ASPNC
AccessioniPrimary (citable) accession number: A2QFF8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.