SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2QEK7

- DAPB_ASPNC

UniProt

A2QEK7 - DAPB_ASPNC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Probable dipeptidyl-aminopeptidase B
Gene
dapB, An02g11420
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline By similarity.

Catalytic activityi

Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei739 – 7391Charge relay system By similarity
Active sitei816 – 8161Charge relay system By similarity
Active sitei849 – 8491Charge relay system By similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. dipeptidyl-peptidase activity Source: ASPGD
  3. serine-type peptidase activity Source: UniProtKB-KW

GO - Biological processi

  1. proteolysis Source: ASPGD
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease, Serine protease

Protein family/group databases

MEROPSiS09.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dipeptidyl-aminopeptidase B (EC:3.4.14.5)
Short name:
DPAP B
Gene namesi
Name:dapB
ORF Names:An02g11420
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 4R

Subcellular locationi

Vacuole membrane; Single-pass type II membrane protein By similarity
Note: Lysosome-like vacuoles By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei77 – 9721Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini98 – 901804Vacuolar Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. vacuolar membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 901901Probable dipeptidyl-aminopeptidase B
PRO_0000412136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi625 – 6251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi793 – 7931N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi5061.CADANGAP00002590.

Structurei

3D structure databases

ProteinModelPortaliA2QEK7.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi120 – 1256Poly-Ser

Sequence similaritiesi

Belongs to the peptidase S9B family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000189891.
OrthoDBiEOG72VHFG.

Family and domain databases

Gene3Di2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view]
PfamiPF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.

Sequencei

Sequence statusi: Complete.

A2QEK7-1 [UniParc]FASTAAdd to Basket

« Hide

MSSPRPSTSS TSSDSGLSVD TTAYPEESKY TSTAPGAGGL SDENRYRDVE    50
EGEAGADEPF LPSAKKQAAS GSRTSRLIWG LVILCVAGWL WGLVLFVTQN 100
RSAQQSVSEA LQSHESGAIS GSSSSGKPVT LEQVLTGQWL PRSHAVSWIA 150
GPNGEDGLLV EQGEDQGKGY LRVDDIRSRK GDATSQESRV LMEKAIVQVD 200
GRTIFPVSTW PSPNLNKVLL LSEREKNWRH SFTGKYWIFD VATQTAQPLD 250
PSNPDGRVQL AIWSPTSDMV AFVRDNNLYL RKLSSKEVVP ITKDGGADLF 300
YGIPDWVYEE EVFSGNSVTW WSGDGKYVAF LRTNETAVPE FPVQYYLSRP 350
SGKRPPPGLE DYPEVREIKY PKAGAPNPVV SLQFYDVEKQ EVFSIEAPDN 400
FEDDDRIIIE IVWGTEGKIL VRATNRESDV LKVFLFDTKA RTSKLVRVEN 450
VADIDGGWVE PTQYTWFIPA DPSNGRPHDG YLDTVIHEGY EHLGYFTPLD 500
NSEPILLTQG EWEVVDAPTA VDLRKGIVYF ISTKESPTER HLYQVNLDGS 550
NLKPLTDTSK PGYYDVSFSH GTGYALLSYR GPSIPWQAIV NTETDELKYE 600
ETIEDNAGLA RMVDSYALPT EIYQNVTIDG FTLQVVERRP PHFNPAKKYP 650
VLFYLYNGPR SQTVDRKFNI DFQSYVASSL GYIVVTVDGR GTGFSGRKTR 700
CIVRGNLGYY EAYDQITTAK LWGEKPYVDE TRMSIWGWSY GGFMTLKTLE 750
QDAGQTFQYG MAVAPVTDWR HYDSIYTERY MHTPAHNPNG YDNTSITDMT 800
ALQQTVRFLV IHGASDDNVH IQNTLVLVDK LDLAGVQNYD LHFYPDSDHS 850
INFHNAHRMV YERLSSWLVN AFNDEWHRIA DPVPDDSMWE KVKRSLPMLV 900
K 901
Length:901
Mass (Da):101,294
Last modified:March 6, 2007 - v1
Checksum:iF058BA27F2450237
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270029 Genomic DNA. Translation: CAK37870.1.

Genome annotation databases

EnsemblFungiiCADANGAT00002663; CADANGAP00002590; CADANGAG00002663.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM270029 Genomic DNA. Translation: CAK37870.1 .

3D structure databases

ProteinModelPortali A2QEK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5061.CADANGAP00002590.

Protein family/group databases

MEROPSi S09.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00002663 ; CADANGAP00002590 ; CADANGAG00002663 .

Phylogenomic databases

HOGENOMi HOG000189891.
OrthoDBi EOG72VHFG.

Family and domain databases

Gene3Di 2.140.10.30. 1 hit.
3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR001375. Peptidase_S9.
IPR002469. Peptidase_S9B.
[Graphical view ]
Pfami PF00930. DPPIV_N. 1 hit.
PF00326. Peptidase_S9. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiDAPB_ASPNC
AccessioniPrimary (citable) accession number: A2QEK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: March 6, 2007
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi