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A2QBQ3

- EGLX_ASPNC

UniProt

A2QBQ3 - EGLX_ASPNC

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Protein
Probable endo-1,3(4)-beta-glucanase An02g00850
Gene
An02g00850
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates By similarity.

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401Nucleophile By similarity
Active sitei145 – 1451Proton donor By similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase An02g00850 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase An02g00850
Gene namesi
ORF Names:An02g00850
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 4R

Subcellular locationi

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 717693Probable endo-1,3(4)-beta-glucanase An02g00850
PRO_5000219530Add
BLAST
Propeptidei718 – 73922Removed in mature form Reviewed prediction
PRO_0000395090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi396 – 3961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi459 – 4591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi482 – 4821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi526 – 5261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi537 – 5371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi569 – 5691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi581 – 5811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi592 – 5921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi620 – 6201N-linked (GlcNAc...) Reviewed prediction
Lipidationi717 – 7171GPI-anchor amidated glycine Reviewed prediction

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA2QBQ3.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi287 – 2926Poly-Ser
Compositional biasi325 – 686362Ala-rich
Add
BLAST
Compositional biasi419 – 706288Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2QBQ3-1 [UniParc]FASTAAdd to Basket

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MPTSTLLWSV GSLALSSMVL PAAASSYELV ETWKGEDFLT AFDFYTGADP    50
TNGFVTYANQ SYAESTGLVK VNSNGTFYMG VDHTTKLSTN GPGRESVRIG 100
SNKYYDEGLF IIDLQHMPGS VCGTWPAFWS TGKNWPTDGE IDIIEGVNKN 150
EANEIVLHTS GTCQVSSQKM SGTLTSTECG EDAGTTGCVV EGTQGSSGTP 200
FNENGGGVYA MQWTDEFLKF WFFPRGSIPS SITKGDPDVA AFGTPMAHME 250
GSCSIAEHFK AQQFIFDTTF CGDWAGGVYS TSGCPVSDSS SSFKSCVAYV 300
AENPTAFAES YWEINYIKIY QTGVAASASA SASHVESAAS VAETISAVRE 350
GTNSVVATTT AATIAVTSTA DAETATTMAG ATTVAASTET SAADENGSSA 400
STSTHYVTMT TTICPIAESS SAAAALAGGS SEATEASNSE GSPAAATPSS 450
VTGASAEANE SESTSAAVTT PSTSTGASAE ANGSESSSAS EAGSVAGATP 500
SSVSTTGASG EADSSEGASA AATPSNVSST GASAEANGSE DSSASSEAKT 550
VAPSIPSSVT GASAEANGND SASSNAATAS NVSGASAQAG DNESTPASAG 600
ANAGSSAAPS SVSGASAEAN GSEGSSSHSS GSQAGAHSYG SVPSSAAAYG 650
RPAPSSSSHA FATAPSSTGS SRVPTSAAAA NNAAAATQGS SASGSNSGSS 700
GHGSSSATTP STPVFTGGAN KLTLGASSVL SVLAFALLA 739
Length:739
Mass (Da):72,556
Last modified:March 6, 2007 - v1
Checksum:i7640750996F31B92
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM269996 Genomic DNA. Translation: CAK96300.1.
RefSeqiXP_001399223.1. XM_001399186.1.

Genome annotation databases

EnsemblFungiiCADANGAT00001593; CADANGAP00001543; CADANGAG00001593.
GeneIDi4978566.
KEGGiang:ANI_1_2196024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AM269996 Genomic DNA. Translation: CAK96300.1 .
RefSeqi XP_001399223.1. XM_001399186.1.

3D structure databases

ProteinModelPortali A2QBQ3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH16. Glycoside Hydrolase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00001593 ; CADANGAP00001543 ; CADANGAG00001593 .
GeneIDi 4978566.
KEGGi ang:ANI_1_2196024.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiEGLX_ASPNC
AccessioniPrimary (citable) accession number: A2QBQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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