Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2QBQ3

- EGLX_ASPNC

UniProt

A2QBQ3 - EGLX_ASPNC

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Probable endo-1,3(4)-beta-glucanase An02g00850

Gene

An02g00850

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Mixed-linked glucanase involved in the degradation of complex natural cellulosic substrates.By similarity

Catalytic activityi

Endohydrolysis of (1->3)- or (1->4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei140 – 1401NucleophileBy similarity
Active sitei145 – 1451Proton donorBy similarity

GO - Molecular functioni

  1. glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC
  2. glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group Source: UniProtKB-EC

GO - Biological processi

  1. cellulose catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH16. Glycoside Hydrolase Family 16.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endo-1,3(4)-beta-glucanase An02g00850 (EC:3.2.1.6)
Alternative name(s):
Mixed-linked glucanase An02g00850
Gene namesi
ORF Names:An02g00850
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
ProteomesiUP000006706: Chromosome 4R

Subcellular locationi

Cell membrane By similarity; Lipid-anchorGPI-anchor By similarity

GO - Cellular componenti

  1. anchored component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 717693Probable endo-1,3(4)-beta-glucanase An02g00850PRO_5000219530Add
BLAST
Propeptidei718 – 73922Removed in mature formSequence AnalysisPRO_0000395090Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi459 – 4591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi526 – 5261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi537 – 5371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi569 – 5691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi581 – 5811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi592 – 5921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Lipidationi717 – 7171GPI-anchor amidated glycineSequence Analysis

Keywords - PTMi

Glycoprotein, GPI-anchor, Lipoprotein

Structurei

3D structure databases

ProteinModelPortaliA2QBQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi287 – 2926Poly-Ser
Compositional biasi325 – 686362Ala-richAdd
BLAST
Compositional biasi419 – 706288Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 16 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG12793.
HOGENOMiHOG000166269.
OrthoDBiEOG7HB5KN.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2QBQ3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPTSTLLWSV GSLALSSMVL PAAASSYELV ETWKGEDFLT AFDFYTGADP
60 70 80 90 100
TNGFVTYANQ SYAESTGLVK VNSNGTFYMG VDHTTKLSTN GPGRESVRIG
110 120 130 140 150
SNKYYDEGLF IIDLQHMPGS VCGTWPAFWS TGKNWPTDGE IDIIEGVNKN
160 170 180 190 200
EANEIVLHTS GTCQVSSQKM SGTLTSTECG EDAGTTGCVV EGTQGSSGTP
210 220 230 240 250
FNENGGGVYA MQWTDEFLKF WFFPRGSIPS SITKGDPDVA AFGTPMAHME
260 270 280 290 300
GSCSIAEHFK AQQFIFDTTF CGDWAGGVYS TSGCPVSDSS SSFKSCVAYV
310 320 330 340 350
AENPTAFAES YWEINYIKIY QTGVAASASA SASHVESAAS VAETISAVRE
360 370 380 390 400
GTNSVVATTT AATIAVTSTA DAETATTMAG ATTVAASTET SAADENGSSA
410 420 430 440 450
STSTHYVTMT TTICPIAESS SAAAALAGGS SEATEASNSE GSPAAATPSS
460 470 480 490 500
VTGASAEANE SESTSAAVTT PSTSTGASAE ANGSESSSAS EAGSVAGATP
510 520 530 540 550
SSVSTTGASG EADSSEGASA AATPSNVSST GASAEANGSE DSSASSEAKT
560 570 580 590 600
VAPSIPSSVT GASAEANGND SASSNAATAS NVSGASAQAG DNESTPASAG
610 620 630 640 650
ANAGSSAAPS SVSGASAEAN GSEGSSSHSS GSQAGAHSYG SVPSSAAAYG
660 670 680 690 700
RPAPSSSSHA FATAPSSTGS SRVPTSAAAA NNAAAATQGS SASGSNSGSS
710 720 730
GHGSSSATTP STPVFTGGAN KLTLGASSVL SVLAFALLA
Length:739
Mass (Da):72,556
Last modified:March 6, 2007 - v1
Checksum:i7640750996F31B92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM269996 Genomic DNA. Translation: CAK96300.1.
RefSeqiXP_001399223.1. XM_001399186.1.

Genome annotation databases

EnsemblFungiiCADANGAT00001593; CADANGAP00001543; CADANGAG00001593.
GeneIDi4978566.
KEGGiang:ANI_1_2196024.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM269996 Genomic DNA. Translation: CAK96300.1 .
RefSeqi XP_001399223.1. XM_001399186.1.

3D structure databases

ProteinModelPortali A2QBQ3.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH16. Glycoside Hydrolase Family 16.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii CADANGAT00001593 ; CADANGAP00001543 ; CADANGAG00001593 .
GeneIDi 4978566.
KEGGi ang:ANI_1_2196024.

Phylogenomic databases

eggNOGi NOG12793.
HOGENOMi HOG000166269.
OrthoDBi EOG7HB5KN.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88."
    Pel H.J., de Winde J.H., Archer D.B., Dyer P.S., Hofmann G., Schaap P.J., Turner G., de Vries R.P., Albang R., Albermann K., Andersen M.R., Bendtsen J.D., Benen J.A.E., van den Berg M., Breestraat S., Caddick M.X., Contreras R., Cornell M.
    , Coutinho P.M., Danchin E.G.J., Debets A.J.M., Dekker P., van Dijck P.W.M., van Dijk A., Dijkhuizen L., Driessen A.J.M., d'Enfert C., Geysens S., Goosen C., Groot G.S.P., de Groot P.W.J., Guillemette T., Henrissat B., Herweijer M., van den Hombergh J.P.T.W., van den Hondel C.A.M.J.J., van der Heijden R.T.J.M., van der Kaaij R.M., Klis F.M., Kools H.J., Kubicek C.P., van Kuyk P.A., Lauber J., Lu X., van der Maarel M.J.E.C., Meulenberg R., Menke H., Mortimer M.A., Nielsen J., Oliver S.G., Olsthoorn M., Pal K., van Peij N.N.M.E., Ram A.F.J., Rinas U., Roubos J.A., Sagt C.M.J., Schmoll M., Sun J., Ussery D., Varga J., Vervecken W., van de Vondervoort P.J.J., Wedler H., Woesten H.A.B., Zeng A.-P., van Ooyen A.J.J., Visser J., Stam H.
    Nat. Biotechnol. 25:221-231(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CBS 513.88 / FGSC A1513.

Entry informationi

Entry nameiEGLX_ASPNC
AccessioniPrimary (citable) accession number: A2QBQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3