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A2Q9N1 (CREB_ASPNC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable ubiquitin carboxyl-terminal hydrolase creB

EC=3.4.19.12
Alternative name(s):
Carbon catabolite repression protein B
Deubiquitinating enzyme creB
Ubiquitin thioesterase creB
Ubiquitin-hydrolyzing enzyme creB
Ubiquitin-specific-processing protease creB
Gene names
Name:creB
ORF Names:An01g08470
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ubiquitin thioesterase component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Deubiquitinates the creA catabolic repressor and the quinate permease qutD. Plays also a role in response to carbon starvation and the control of extracellular proteases activity By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with creA, creC and qutD By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence caution

The sequence CAK43937.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 758758Probable ubiquitin carboxyl-terminal hydrolase creB
PRO_0000395681

Regions

Domain57 – 468412USP
Coiled coil573 – 63159 Potential
Compositional bias530 – 57243Pro-rich

Sites

Active site661Nucleophile By similarity
Active site4191Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
A2Q9N1 [UniParc].

Last modified July 13, 2010. Version 2.
Checksum: 66D526B4DA07ED6D

FASTA75884,902
        10         20         30         40         50         60 
MGSFLRSFRR DVGSSTPSVG ATPAKKEPLA LPITPLEKML QEMGSDSVRQ DGSDKFFGME 

        70         80         90        100        110        120 
NYGNTCYCNS ILQCLYYSVP FREAVLNYPT RTPIESLEAA LAKNLRYQNF AANQEAEAQA 

       130        140        150        160        170        180 
EKQRLANAQR PGAPPAQPPK PEDKDSSEYK KKIALQSLPL LETKNNAGSY GMSESLFTSL 

       190        200        210        220        230        240 
KDIFESVVAS QSRIGIVRPQ HFLDVLRREN EMFRSAMHQD AHEFLNLVLN EVVANVEAEA 

       250        260        270        280        290        300 
MKQPIPSLPP ADTTDSSRQS ISSGSKTPNT TRWVHELFEG TLTSETQCLT CENVSQRDEI 

       310        320        330        340        350        360 
FLDLSVDLEQ HSSVTSCLRK FSAEEMLCER NKFHCDNCGG LQEAEKRMKI KRLPRILALH 

       370        380        390        400        410        420 
LKRFKYTEDL QRLQKLFHRV VYPYHLRLFN TTDDAEDPDR LYELYAVVVH IGGGPYHGHY 

       430        440        450        460        470        480 
VSIIKTQDRG WLLFDDEMVE PVDKNYVRNF FGDKPGLACA YVLFYQETTL EAVLKEQEME 

       490        500        510        520        530        540 
NMNASAADAN EAAVKPNGFP QPAGLAHVHS ASQIPVQDEP QRHTGLRRAP TAPQLPTHTE 

       550        560        570        580        590        600 
YPGPDIEPSS PAVATPPPVP PIPETANRPL SPKKSDIQSK KERAKEEKER KAAEKEMEKQ 

       610        620        630        640        650        660 
RRKEQEARVK ENQRREEAEL KAALEASKAS KADEDRRNPT ENGKDGDPKR SSNGLSRLKR 

       670        680        690        700        710        720 
GSKSFSQRLG KDKESRASSS GLPSVPSAEP LTPNPVPLEP VQQLSPRKAS PPKESHVVHK 

       730        740        750 
PLGQDDEPDA LKSPKGDRAG HGKWRSFSIR KKSFSILS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM269976 Genomic DNA. Translation: CAK43937.1. Sequence problems.
RefSeqXP_001389270.2. XM_001389233.2.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5061.CADANGAP00000821.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4978128.
KEGGang:ANI_1_1130014.

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000192482.
KOK11872.
OrthoDBEOG7TF7JV.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCREB_ASPNC
AccessionPrimary (citable) accession number: A2Q9N1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: February 19, 2014
This is version 36 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries