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Reviewed, UniProtKB/Swiss-Prot A2Q898 (MCR1_ASPNC)

Last modified February 9, 2010. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NADH-cytochrome b5 reductase 2
    EC=1.6.2.2
Alternative name(s):
    Mitochondrial cytochrome b reductase
Gene names
Name: mcr1
ORF Names: An01g03570
OrganismAspergillus niger (strain CBS 513.88 / FGSC A1513) [Complete proteome]
Taxonomic identifier425011 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesTrichocomaceaemitosporic TrichocomaceaeAspergillus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Function

May mediate the reduction of outer membrane cytochrome b5 By similarity.

Catalytic activity

NADH + 2 ferricytochrome b5 = NAD+ + H+ + 2 ferrocytochrome b5.

Cofactor

FAD By similarity.

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.

Contains 1 FAD-binding FR-type domain.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   DomainTransmembrane
   LigandFAD
Flavoprotein
NAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

mitochondrial outer membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functioncytochrome-b5 reductase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322NADH-cytochrome b5 reductase 2
PRO_0000330172

Regions

Transmembrane31 – 4818 Potential
Domain72 – 176105FAD-binding FR-type
Nucleotide binding179 – 21436FAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A2Q898-1 [UniParc].

Last modified March 6, 2007. Version 1.
Checksum: 831FC260D3A417AE

FASTA32236,090
        10         20         30         40         50         60 
MFARQAFRCA QPLKQGFRKY STEAPKGKSS LAPIYAAVGI TGVGVGLYRY NSATAEAPAA 

        70         80         90        100        110        120 
VDRPKVFKGG DQGWFDLKLS EIEVLNHNTK RLRFEFEDKE ALSGLQVASA LLTKFKPADA 

       130        140        150        160        170        180 
KAVIRPYTPT SDEETPGYID LVVKVYPNGP MSEHLHSMNV GQRLDFKGPI VKYPWETNKH 

       190        200        210        220        230        240 
NHICLIAGGT GITPMYQLAR EIFKNPEDQT KVTLVFGNVK EEDILLKKEF EELENTYPRR 

       250        260        270        280        290        300 
FRAFYVLDNP PKEWTGGKGY ISKELLKTVL PEPKEENIKI FVCGPPGMYK AISGTKNSPT 

       310        320 
DQGELSGILK ELGYSKEQVF KF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AM269959 Genomic DNA. Translation: CAK36895.1.
RefSeqXP_001388787.1.

3D structure databases

SMRA2Q898. Positions 71-322.
ModBaseSearch...

Genome annotation databases

GeneID4978482.
KEGGang:An01g03570.

Phylogenomic databases

HOGENOMHBG591994.
OrthoDBEOG9TB5TC.

Family and domain databases

InterProIPR017927. Fd_Rdtase_FAD-bd.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR001834. NADH-Cyt_B5_reductase.
IPR008333. OxRdtase_FAD-bd_dom.
IPR001433. OxRdtase_FAD/NAD_bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00970. FAD_binding_6. 1 hit.
PF00175. NAD_binding_1. 1 hit.
[Graphical view]
PRINTSPR00406. CYTB5RDTASE.
PR00371. FPNCR.
PROSITEPS51384. FAD_FR. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMCR1_ASPNC
AccessionPrimary (citable) accession number: A2Q898
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 6, 2007
Last modified: February 9, 2010
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectFPAP (Fungal Proteome Annotation Project)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents