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Protein

Catalase-peroxidase

Gene

katG

Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei93Transition state stabilizerUniRule annotation1
Active sitei97Proton acceptorUniRule annotation1
Metal bindingi283Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Protein family/group databases

PeroxiBasei5224. AnCP01.

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidaseUniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CPUniRule annotation
Alternative name(s):
Peroxidase/catalaseUniRule annotation
Gene namesi
Name:katGUniRule annotation
ORF Names:An01g01830
OrganismiAspergillus niger (strain CBS 513.88 / FGSC A1513)
Taxonomic identifieri425011 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000006706 Componenti: Chromosome 2R

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • intracellular Source: ASPGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003541011 – 762Catalase-peroxidaseAdd BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki96 ↔ 242Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-268)UniRule annotation
Cross-linki242 ↔ 268Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-96)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Proteomic databases

PRIDEiA2Q7T1.

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA2Q7T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2Q7T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEAKCPFSQ SRSNANVAGG GTRNTDWWPD QLNLGILRQH APASNPFERD
60 70 80 90 100
FDYTAAFNSL DYYALKKDLH ALMTDSQDWW PADFGHYGGL FIRMAWHSAG
110 120 130 140 150
TYRVFDGRGG GGQGQQRFAP LNSWPDNASL DKARRLLWPI KQKYGAKISW
160 170 180 190 200
ADLMLLAGNV ALESMGFKTY GFSGGRADTW EADESVYWGG ESTWMGNDVR
210 220 230 240 250
YSDGFPGVTK HGALSGDEPP HRNIHTRDLE KPLAASHMGL IYVNPEGPDG
260 270 280 290 300
NPDPVAAARD IRTTFGRMGM NDEETVALIA GGHSFGKTHG AASSENVDVE
310 320 330 340 350
PAAAGLENQG LGWSNRYQSG KGPHTITSGI EVTWTKTPTK WSHAFLEYLF
360 370 380 390 400
RFDWELTKSP GGANQWQAKN TEAIIPDAYD PSKKHLPKML TTDLSLRYDP
410 420 430 440 450
AYEKIARRFL DHPDEFADAF SRAWFKLLHR DMGPRTRYIG PEAPTEDLIW
460 470 480 490 500
QDPIPAVNHT LVDANDIAAL KRTILDTGLN KSNFVSTAWA SASTFRGTDK
510 520 530 540 550
RGGANGARIR LAPQRQWEVN NQPWLEETLS ALEKIQKDFN DRVSSTGKKI
560 570 580 590 600
SLADLIVLAG CAAVEKAAQE AGQTITVPFT PGRMDASQEQ TEVESFSHLE
610 620 630 640 650
PVADGFRNYG KSSSRVRAEH YLVDKAHLLT LTAPEMTVLV GGLRVLNTNY
660 670 680 690 700
DGSKHGVLTS SPGRLTNDFF TNVLDMNTAW KAKDGGRDLY EGTDRKTGQP
710 720 730 740 750
KWTATRADLV FGSHAELRAL AEVYGSSDGQ EKFVKDFVSA WDKVMNLDRF
760
DLKGSGIARS KL
Length:762
Mass (Da):84,251
Last modified:March 6, 2007 - v1
Checksum:i373EFFF72FC82CDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM269954 Genomic DNA. Translation: CAK43554.1.
RefSeqiXP_001388622.1. XM_001388585.2.

Genome annotation databases

EnsemblFungiiCAK43554; CAK43554; An01g01830.
GeneIDi4977099.
KEGGiang:ANI_1_228014.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AM269954 Genomic DNA. Translation: CAK43554.1.
RefSeqiXP_001388622.1. XM_001388585.2.

3D structure databases

ProteinModelPortaliA2Q7T1.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

PeroxiBasei5224. AnCP01.

Proteomic databases

PRIDEiA2Q7T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiCAK43554; CAK43554; An01g01830.
GeneIDi4977099.
KEGGiang:ANI_1_228014.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OrthoDBiEOG092C0YTX.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG_ASPNC
AccessioniPrimary (citable) accession number: A2Q7T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.