Reviewed, UniProtKB/Swiss-Prot A2Q127 (EF1G_HORSE)

Names and origin

Protein names

Recommended name:
    Elongation factor 1-gamma
      Short name=EF-1-gamma
Alternative name(s):
    eEF-1B gamma

Gene names

Name:

EEF1G

Organism

Equus caballus (Horse)

Taxonomic identifier

9796 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus

Protein attributes

Sequence length	437 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Probably plays a role in anchoring the complex to other cellular components By similarity.
Subunit structure	EF-1 is composed of four subunits: alpha, beta, delta, and gamma By similarity.
Sequence similarities	Contains 1 EF-1-gamma C-terminal domain. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Biological process	Protein biosynthesis
Molecular function	Elongation factor
PTM	Acetylation Phosphoprotein
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: InterPro
Cellular component	eukaryotic translation elongation factor 1 complex Inferred from electronic annotation. Source: InterPro
Molecular function	translation elongation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 437	436	Elongation factor 1-gamma		PRO_0000286045
Regions
	Domain	2 – 87	86	GST N-terminal
	Domain	88 – 216	129	GST C-terminal
	Domain	276 – 437	162	EF-1-gamma C-terminal
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Modified residue	43	1	Phosphothreonine By similarity
	Modified residue	46	1	Phosphothreonine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2Q127-1 [UniParc]. Last modified March 6, 2007. Version 1. Checksum: DC9F0CDF139E68C2	FASTA	437	50,049
	10 20 30 40 50 60 MAAGTLYTYP ENWRAFKALI AAQYSGAQVR VLSAPPHFHF GQTNRTPEFL RKFPAGKVPA 70 80 90 100 110 120 FEGDDGFCVF ESNAIAYYVS NEELRGSTPE AAAQVVQWVS FADSDIVPPA STWVFPTLGI 130 140 150 160 170 180 MHHNKQATEN AKEEVRRILG LLDAHLKTRT FLVGERVTLA DITVVCTLLW LYKQVLEPSF 190 200 210 220 230 240 RQAFPNTNRW FLTCINQPQF RAVLGEVKLC EKMAQFDAKK FAESQPKKDT PRKEKGSREE 250 260 270 280 290 300 KQKPQAERKE EKKAAAPAPE EEMDECEQAL AAEPKAKDPF AHLPKSTFVL DEFKRKYSNE 310 320 330 340 350 360 DTLSVALPYF WEHFDKDGWS LWYSEYRFPE ELTQTFMSCN LITGMFQRLD KLRKNAFASV 370 380 390 400 410 420 ILFGTNNSSS ISGVWVFRGQ ELAFPLSPDW QVDYESYTWR KLDPGSEEAQ TLVREYFSWE 430 GAFQHVGKAF NQGKIFK

References

[1]	"Cloning of genes expressed in equine tendon." Hasegawa T., Hayashi K., Kagawa Y., Akiyama Y., Suzuki Y., Sugano S., Ishida N. Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Thoroughbred. Tissue: Tendon.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB292250 mRNA. Translation: BAF46268.1.
RefSeq	NP_001075254.1.
UniGene	Eca.13135
3D structure databases
SMR	A2Q127. Positions 276-437.
ModBase	Search...
Genome annotation databases
Ensembl	ENSECAG00000014334. Equus caballus. [Contig view]
GeneID	100009686.
KEGG	ecb:100009686.
Phylogenomic databases
HOVERGEN	A2Q127.
OMA	A2Q127. KSIPYFW.
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR001662. Transl_elong_EF1_G_con. [Graphical view]
Gene3D	G3DSA:1.20.1050.10. GST_C_like. 1 hit. G3DSA:3.30.70.1010. Transl_elong_EF1_G_con. 1 hit.
Pfam	PF00647. EF1G. 1 hit. PF00043. GST_C. 1 hit. PF02798. GST_N. 1 hit. [Graphical view]
ProDom	PD006217. EF1_G. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS50040. EF1G_C. 1 hit. PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EF1G_HORSE

Accession

Primary (citable) accession number: A2Q127

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 1, 2007
Last sequence update:	March 6, 2007
Last modified:	June 16, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)