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A2P2R3

- YM084_YEAST

UniProt

A2P2R3 - YM084_YEAST

Protein

Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

YMR084W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins).By similarity

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

    GO - Biological processi

    1. glutamine metabolic process Source: UniProtKB-KW
    2. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32784-MONOMER.
    ReactomeiREACT_188969. XBP1(S) activates chaperone genes.
    REACT_189213. Synthesis of UDP-N-acetyl-glucosamine.
    UniPathwayiUPA00113; UER00528.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
    Short name:
    GFAT
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase
    Hexosephosphate aminotransferase
    Gene namesi
    Ordered Locus Names:YMR084W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XIII

    Organism-specific databases

    SGDiS000004689. YMR084W.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 262262Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000269757Add
    BLAST

    Expressioni

    Gene expression databases

    GenevestigatoriQ6B308.

    Interactioni

    Protein-protein interaction databases

    BioGridi35259. 2 interactions.
    STRINGi4932.YMR084W.

    Structurei

    3D structure databases

    ProteinModelPortaliA2P2R3.
    SMRiA2P2R3. Positions 2-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 262261Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    HOGENOMiHOG000203549.
    OMAiLRRANCH.
    OrthoDBiEOG7034RG.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR017932. GATase_2_dom.
    IPR029055. Ntn_hydrolases_N.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2P2R3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCGIFGYCNF LIEKTRGEII DTLIEGLQAL EYKEYDSSGI SIQGDELESL    50
    NIYKQTGKIS SLKEEIDLYN LNKNLPFISH CGIAHTRRAT HGGLRRANCH 100
    PHNSDPSNEF VVVHNGVITN FANLKALLMA KGYVFKSDTD TECIPKLYKH 150
    IYDTSIELGY NLDFHVLTNL VLKELEGSYG LLCTSSHFPD EVVAARKGSP 200
    LVIGVKGKTD MDVNFVEVEY LDQEEDYLKL NTQTKSSGNV LAAAPVKYNT 250
    CLRKSPPFVH NT 262
    Length:262
    Mass (Da):29,272
    Last modified:February 20, 2007 - v1
    Checksum:iCAEC5457BEB33DFD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49259 Genomic DNA. Translation: CAA89230.1.
    AY692572 Genomic DNA. Translation: AAT92591.1.
    AY268137 Genomic DNA. Translation: AAR26283.1.
    BK006946 Genomic DNA. Translation: DAA09981.1.
    PIRiS54459.
    RefSeqiNP_013801.1. NM_001182583.1.

    Genome annotation databases

    EnsemblFungiiYMR084W; YMR084W; YMR084W.
    GeneIDi855108.
    KEGGisce:YMR084W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z49259 Genomic DNA. Translation: CAA89230.1 .
    AY692572 Genomic DNA. Translation: AAT92591.1 .
    AY268137 Genomic DNA. Translation: AAR26283.1 .
    BK006946 Genomic DNA. Translation: DAA09981.1 .
    PIRi S54459.
    RefSeqi NP_013801.1. NM_001182583.1.

    3D structure databases

    ProteinModelPortali A2P2R3.
    SMRi A2P2R3. Positions 2-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 35259. 2 interactions.
    STRINGi 4932.YMR084W.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YMR084W ; YMR084W ; YMR084W .
    GeneIDi 855108.
    KEGGi sce:YMR084W.

    Organism-specific databases

    SGDi S000004689. YMR084W.

    Phylogenomic databases

    HOGENOMi HOG000203549.
    OMAi LRRANCH.
    OrthoDBi EOG7034RG.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00528 .
    BioCyci YEAST:G3O-32784-MONOMER.
    Reactomei REACT_188969. XBP1(S) activates chaperone genes.
    REACT_189213. Synthesis of UDP-N-acetyl-glucosamine.

    Miscellaneous databases

    NextBioi 978440.

    Gene expression databases

    Genevestigatori Q6B308.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR017932. GATase_2_dom.
    IPR029055. Ntn_hydrolases_N.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    4. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
      Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
      Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 246-262, CONFIRMATION OF FRAMESHIFT.
      Strain: ATCC 204511 / S288c / AB972.

    Entry informationi

    Entry nameiYM084_YEAST
    AccessioniPrimary (citable) accession number: A2P2R3
    Secondary accession number(s): D6VZQ7
    , E9P8R5, Q3E7C0, Q6B308, Q6WV01
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 20, 2010
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Caution

    This is a truncated version of a putative glutamine--fructose-6-phosphate aminotransferase. Strain S288c has a frameshift in position 258, which disrupts the gene coding for this protein and produces two ORFs YMR084W and YMR085W. A contiguous sequence for this protein can be found in strain YJM789 (AC A6ZME2).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome XIII
      Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

    External Data

    Dasty 3