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A2P2R3

- YM084_YEAST

UniProt

A2P2R3 - YM084_YEAST

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Protein
Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene
YMR084W
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins) By similarity.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21Nucleophile; for GATase activity By similarity

GO - Molecular functioni

  1. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

GO - Biological processi

  1. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
  2. glutamine metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciYEAST:G3O-32784-MONOMER.
ReactomeiREACT_188969. XBP1(S) activates chaperone genes.
REACT_189213. Synthesis of UDP-N-acetyl-glucosamine.
UniPathwayiUPA00113; UER00528.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Short name:
GFAT
Alternative name(s):
D-fructose-6-phosphate amidotransferase
Hexosephosphate aminotransferase
Gene namesi
Ordered Locus Names:YMR084W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XIII

Organism-specific databases

SGDiS000004689. YMR084W.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 262262Putative glutamine--fructose-6-phosphate aminotransferase [isomerizing]
PRO_0000269757Add
BLAST

Expressioni

Gene expression databases

GenevestigatoriQ6B308.

Interactioni

Protein-protein interaction databases

BioGridi35259. 2 interactions.
STRINGi4932.YMR084W.

Structurei

3D structure databases

ProteinModelPortaliA2P2R3.
SMRiA2P2R3. Positions 2-221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 262261Glutamine amidotransferase type-2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000203549.
OMAiLRRANCH.
OrthoDBiEOG7034RG.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2P2R3-1 [UniParc]FASTAAdd to Basket

« Hide

MCGIFGYCNF LIEKTRGEII DTLIEGLQAL EYKEYDSSGI SIQGDELESL    50
NIYKQTGKIS SLKEEIDLYN LNKNLPFISH CGIAHTRRAT HGGLRRANCH 100
PHNSDPSNEF VVVHNGVITN FANLKALLMA KGYVFKSDTD TECIPKLYKH 150
IYDTSIELGY NLDFHVLTNL VLKELEGSYG LLCTSSHFPD EVVAARKGSP 200
LVIGVKGKTD MDVNFVEVEY LDQEEDYLKL NTQTKSSGNV LAAAPVKYNT 250
CLRKSPPFVH NT 262
Length:262
Mass (Da):29,272
Last modified:February 20, 2007 - v1
Checksum:iCAEC5457BEB33DFD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89230.1.
AY692572 Genomic DNA. Translation: AAT92591.1.
AY268137 Genomic DNA. Translation: AAR26283.1.
BK006946 Genomic DNA. Translation: DAA09981.1.
PIRiS54459.
RefSeqiNP_013801.1. NM_001182583.1.

Genome annotation databases

EnsemblFungiiYMR084W; YMR084W; YMR084W.
GeneIDi855108.
KEGGisce:YMR084W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z49259 Genomic DNA. Translation: CAA89230.1 .
AY692572 Genomic DNA. Translation: AAT92591.1 .
AY268137 Genomic DNA. Translation: AAR26283.1 .
BK006946 Genomic DNA. Translation: DAA09981.1 .
PIRi S54459.
RefSeqi NP_013801.1. NM_001182583.1.

3D structure databases

ProteinModelPortali A2P2R3.
SMRi A2P2R3. Positions 2-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 35259. 2 interactions.
STRINGi 4932.YMR084W.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YMR084W ; YMR084W ; YMR084W .
GeneIDi 855108.
KEGGi sce:YMR084W.

Organism-specific databases

SGDi S000004689. YMR084W.

Phylogenomic databases

HOGENOMi HOG000203549.
OMAi LRRANCH.
OrthoDBi EOG7034RG.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .
BioCyci YEAST:G3O-32784-MONOMER.
Reactomei REACT_188969. XBP1(S) activates chaperone genes.
REACT_189213. Synthesis of UDP-N-acetyl-glucosamine.

Miscellaneous databases

NextBioi 978440.

Gene expression databases

Genevestigatori Q6B308.

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR017932. GATase_2_dom.
IPR029055. Ntn_hydrolases_N.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  4. "Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii."
    Brachat S., Dietrich F.S., Voegeli S., Zhang Z., Stuart L., Lerch A., Gates K., Gaffney T.D., Philippsen P.
    Genome Biol. 4:R45.1-R45.13(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 246-262, CONFIRMATION OF FRAMESHIFT.
    Strain: ATCC 204511 / S288c / AB972.

Entry informationi

Entry nameiYM084_YEAST
AccessioniPrimary (citable) accession number: A2P2R3
Secondary accession number(s): D6VZQ7
, E9P8R5, Q3E7C0, Q6B308, Q6WV01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

This is a truncated version of a putative glutamine--fructose-6-phosphate aminotransferase. Strain S288c has a frameshift in position 258, which disrupts the gene coding for this protein and produces two ORFs YMR084W and YMR085W. A contiguous sequence for this protein can be found in strain YJM789 (AC A6ZME2).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

External Data

Dasty 3

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