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A2NXD2

- A2NXD2_HUMAN

UniProt

A2NXD2 - A2NXD2_HUMAN

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Protein
Submitted name:

Immunolglobulin kappa light chain variable region L22

Gene

IGLV

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

GO - Biological processi

  1. complement activation Source: Reactome
  2. complement activation, classical pathway Source: Reactome
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  5. innate immune response Source: Reactome
  6. regulation of immune response Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Submitted name:
Immunolglobulin kappa light chain variable region L22Imported
Gene namesi
Name:IGLVImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei‹1 – 22›22 PotentialImportedAdd
BLAST
Chaini23 – ›117›95 PotentialImportedPRO_5000219025Add
BLAST

Proteomic databases

PaxDbiA2NXD2.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000374813.

Structurei

3D structure databases

ProteinModelPortaliA2NXD2.
SMRiA2NXD2. Positions 23-117.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SignalImported

Phylogenomic databases

HOGENOMiHOG000059537.
HOVERGENiHBG018013.
OMAiEANSELH.
PhylomeDBiA2NXD2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00406. IGv. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2NXD2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDMRVPAQLL GLLLLWLPGV RFDIQMIQSP SFLSASVGDR VSIICWASEG
60 70 80 90 100
ISSNLAWYLQ KPGKSPKLFL YDAKDLHPGV SSRFSGRGSG TDFTLTIISL
110
KPEDFAAYYC KQDFSYP
Length:117
Mass (Da):13,026
Last modified:February 20, 2007 - v1
Checksum:i1B6A9B68A1D171D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei117 – 1171Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72816 Genomic DNA. Translation: CAA51335.1.
PIRiS41811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X72816 Genomic DNA. Translation: CAA51335.1 .
PIRi S41811.

3D structure databases

ProteinModelPortali A2NXD2.
SMRi A2NXD2. Positions 23-117.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000374813.

Proteomic databases

PaxDbi A2NXD2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOGENOMi HOG000059537.
HOVERGENi HBG018013.
OMAi EANSELH.
PhylomeDBi A2NXD2.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Miscellaneous databases

NextBioi 35461226.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
IPR003596. Ig_V-set_subgr.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00406. IGv. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The V kappa genes of the L regions and the repertoire of V kappa gene sequences in the human germ line."
    Huber C., Schable K.F., Huber E., Klein R., Meindl A., Thiebe R., Lamm R., Zachau H.G.
    Eur. J. Immunol. 23:2868-2875(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Placenta StImported.

Entry informationi

Entry nameiA2NXD2_HUMAN
AccessioniPrimary (citable) accession number: A2NXD2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.