ID   A2NTY6_MOUSE            Unreviewed;       144 AA.
AC   A2NTY6;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 81.
DE   SubName: Full=Beta-chain {ECO:0000313|EMBL:CAA26555.1};
DE   Flags: Precursor; Fragment;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:CAA26555.1};
RN   [1] {ECO:0000313|EMBL:CAA26555.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/Ka {ECO:0000313|EMBL:CAA26555.1};
RX   PubMed=2412120; DOI=10.1038/316517a0;
RA   Barth R.K., Kim B.S., Lan N.C., Hunkapiller T., Sobieck N., Winoto A.,
RA   Gershennffeld H., Okada C., Hansburg D., Weissman I.L., Hood L.;
RT   "The murine T-cell receptor uses a limited repertoire of expressed V beta
RT   gene segments.";
RL   Nature 316:517-523(1985).
RN   [2] {ECO:0007829|PDB:2E7L, ECO:0007829|PDB:2OI9}
RP   X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 30-144, AND DISULFIDE BONDS.
RX   PubMed=17418792; DOI=10.1016/j.cell.2007.01.048;
RA   Colf L.A., Bankovich A.J., Hanick N.A., Bowerman N.A., Jones L.L.,
RA   Kranz D.M., Garcia K.C.;
RT   "How a single T cell receptor recognizes both self and foreign MHC.";
RL   Cell 129:135-146(2007).
RN   [3] {ECO:0007829|PDB:2PXY, ECO:0007829|PDB:2Z31}
RP   X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 32-144, AND DISULFIDE BONDS.
RX   PubMed=17694060; DOI=10.1038/ni1502;
RA   Feng D., Bond C.J., Ely L.K., Maynard J., Garcia K.C.;
RT   "Structural evidence for a germline-encoded T cell receptor-major
RT   histocompatibility complex interaction 'codon'.";
RL   Nat. Immunol. 8:975-983(2007).
RN   [4] {ECO:0007829|PDB:2ICW}
RP   X-RAY CRYSTALLOGRAPHY (2.41 ANGSTROMS) OF 30-144, AND DISULFIDE BONDS.
RX   PubMed=17220897; DOI=10.1038/nsmb1193;
RA   Wang L., Zhao Y., Li Z., Guo Y., Jones L.L., Kranz D.M., Mourad W., Li H.;
RT   "Crystal structure of a complete ternary complex of TCR, superantigen and
RT   peptide-MHC.";
RL   Nat. Struct. Mol. Biol. 14:169-171(2007).
RN   [5] {ECO:0007829|PDB:3E2H}
RP   X-RAY CRYSTALLOGRAPHY (3.80 ANGSTROMS) OF 31-144, AND DISULFIDE BONDS.
RX   PubMed=18941216; DOI=10.4049/jimmunol.181.9.6255;
RA   Jones L.L., Colf L.A., Stone J.D., Garcia K.C., Kranz D.M.;
RT   "Distinct CDR3 conformations in TCRs determine the level of cross-
RT   reactivity for diverse antigens, but not the docking orientation.";
RL   J. Immunol. 181:6255-6264(2008).
RN   [6] {ECO:0007829|PDB:3MC0, ECO:0007829|PDB:3OWE}
RP   X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 31-144, AND DISULFIDE BONDS.
RX   PubMed=21059660; DOI=10.1074/jbc.m110.142471;
RA   Fernandez M.M., Cho S., De Marzi M.C., Kerzic M.C., Robinson H.,
RA   Mariuzza R.A., Malchiodi E.L.;
RT   "Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a
RT   mouse T-cell receptor {beta} chain.";
RL   J. Biol. Chem. 286:1189-1195(2011).
RN   [7] {ECO:0007829|PDB:4Y16}
RP   X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 29-144, AND DISULFIDE BONDS.
RX   PubMed=26018083; DOI=10.1074/jbc.M115.654814;
RA   Birkholz A., Nemcovic M., Yu E.D., Girardi E., Wang J., Khurana A.,
RA   Pauwels N., Farber E., Chitale S., Franck R.W., Tsuji M., Howell A.,
RA   Van Calenbergh S., Kronenberg M., Zajonc D.M.;
RT   "Lipid and Carbohydrate Modifications of alpha-Galactosylceramide
RT   Differently Influence Mouse and Human Type I Natural Killer T Cell
RT   Activation.";
RL   J. Biol. Chem. 290:17206-17217(2015).
RN   [8] {ECO:0007829|PDB:4ZAK}
RP   X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 29-144, AND DISULFIDE BONDS.
RX   PubMed=26078271; DOI=10.4049/jimmunol.1500070;
RA   Birkholz A.M., Girardi E., Wingender G., Khurana A., Wang J., Zhao M.,
RA   Zahner S., Illarionov P.A., Wen X., Li M., Yuan W., Porcelli S.A.,
RA   Besra G.S., Zajonc D.M., Kronenberg M.;
RT   "A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-
RT   gamma Production.";
RL   J. Immunol. 195:924-933(2015).
RN   [9] {ECO:0007829|PDB:4Y2D, ECO:0007829|PDB:4Y4F}
RP   X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 29-144 AND DISULFIDE BONDS, X-RAY
RP   CRYSTALLOGRAPHY (2.90 ANGSTROMS) OF 29-144 AND DISULFIDE BONDS, X-RAY
RP   CRYSTALLOGRAPHY (3.05 ANGSTROMS) OF 29-144 AND DISULFIDE BONDS, AND X-RAY
RP   CRYSTALLOGRAPHY (3.19 ANGSTROMS) OF 29-144 AND DISULFIDE BONDS.
RA   Birkholz A., Nemcovic M., Yu E.D., Girardi E., Wang J., Khurana A.,
RA   Pauwels N., Franck R.W., Tsuji M., Howell A., Calenbergh S., Kronenberg M.,
RA   Zajonc D.M.;
RT   "Structural modifications of alphaGalCer in both lipid and carbohydrate
RT   moiety influence activation of murine and human iNKT cells.";
RL   Submitted (FEB-2015) to the PDB data bank.
RN   [10] {ECO:0007829|PDB:6MIV, ECO:0007829|PDB:6MIY}
RP   X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) OF 29-123, AND DISULFIDE BONDS.
RX   PubMed=30556652; DOI=10.1002/cmdc.201800649;
RA   Janssens J., Bitra A., Wang J., Decruy T., Venken K., van der Eycken J.,
RA   Elewaut D., Zajonc D.M., van Calenbergh S.;
RT   "4"-O-Alkylated alpha-Galactosylceramide Analogues as iNKT-Cell Antigens:
RT   Synthetic, Biological, and Structural Studies.";
RL   ChemMedChem 14:147-168(2019).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X02784; CAA26555.1; -; mRNA.
DR   PDB; 2E7L; X-ray; 2.50 A; C/D=30-144.
DR   PDB; 2ICW; X-ray; 2.41 A; J/L=30-144.
DR   PDB; 2OI9; X-ray; 2.35 A; C=30-144.
DR   PDB; 2PXY; X-ray; 2.23 A; B=32-144.
DR   PDB; 2Z31; X-ray; 2.70 A; B=32-144.
DR   PDB; 2Z35; X-ray; 2.20 A; B=32-144.
DR   PDB; 3E2H; X-ray; 3.80 A; C=31-144.
DR   PDB; 3MC0; X-ray; 2.00 A; A/C=31-144.
DR   PDB; 3OWE; X-ray; 2.60 A; A/C/E/G/I/K/M/O=29-144.
DR   PDB; 4Y16; X-ray; 2.60 A; D=29-144.
DR   PDB; 4Y2D; X-ray; 3.05 A; D/H=29-144.
DR   PDB; 4Y4F; X-ray; 3.19 A; D/H=29-144.
DR   PDB; 4Y4H; X-ray; 3.10 A; D/H=29-144.
DR   PDB; 4Y4K; X-ray; 2.90 A; D=29-144.
DR   PDB; 4ZAK; X-ray; 2.82 A; D=29-144.
DR   PDB; 6MIV; X-ray; 2.05 A; D=29-123, D=132-144.
DR   PDB; 6MIY; X-ray; 2.75 A; D/H=29-123, D/H=132-144.
DR   PDB; 6MJ4; X-ray; 2.00 A; D=29-123.
DR   PDB; 6MJ6; X-ray; 2.45 A; D=29-123.
DR   PDB; 6MJA; X-ray; 2.35 A; D=29-123.
DR   PDB; 6MJI; X-ray; 2.30 A; D=29-123, D=132-144.
DR   PDB; 6MJJ; X-ray; 1.93 A; D=29-123.
DR   PDB; 6MJQ; X-ray; 3.00 A; D/H=29-123, D/H=132-144.
DR   PDBsum; 2E7L; -.
DR   PDBsum; 2ICW; -.
DR   PDBsum; 2OI9; -.
DR   PDBsum; 2PXY; -.
DR   PDBsum; 2Z31; -.
DR   PDBsum; 2Z35; -.
DR   PDBsum; 3E2H; -.
DR   PDBsum; 4Y16; -.
DR   PDBsum; 4Y2D; -.
DR   PDBsum; 4Y4F; -.
DR   PDBsum; 4Y4H; -.
DR   PDBsum; 4Y4K; -.
DR   PDBsum; 4ZAK; -.
DR   PDBsum; 6MIV; -.
DR   PDBsum; 6MIY; -.
DR   PDBsum; 6MJ4; -.
DR   PDBsum; 6MJ6; -.
DR   PDBsum; 6MJA; -.
DR   PDBsum; 6MJI; -.
DR   PDBsum; 6MJJ; -.
DR   PDBsum; 6MJQ; -.
DR   AlphaFoldDB; A2NTY6; -.
DR   SMR; A2NTY6; -.
DR   IntAct; A2NTY6; 1.
DR   UCSC; uc009boa.2; mouse.
DR   EvolutionaryTrace; A2NTY6; -.
DR   GO; GO:0042101; C:T cell receptor complex; IEA:UniProtKB-KW.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd05899; IgV_TCR_beta; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR23268:SF42; T CELL RECEPTOR BETA VARIABLE 10-1-RELATED; 1.
DR   PANTHER; PTHR23268; T-CELL RECEPTOR BETA CHAIN; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2E7L, ECO:0007829|PDB:2ICW};
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Immunity {ECO:0000256|ARBA:ARBA00043266};
KW   Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   T cell receptor {ECO:0000256|ARBA:ARBA00043266}.
FT   SIGNAL          1..31
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           32..144
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002644112"
FT   DOMAIN          31..120
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   DISULFID        52..120
FT                   /evidence="ECO:0007829|PDB:2E7L, ECO:0007829|PDB:2ICW"
FT   NON_TER         144
FT                   /evidence="ECO:0000313|EMBL:CAA26555.1"
SQ   SEQUENCE   144 AA;  15812 MW;  4071AC8C0A490C60 CRC64;
     MSNTAFPDPA WNTTLLSWVA LFLLGTKHME AAVTQSPRNK VAVTGGKVTL SCNQTNNHNN
     MYWYRQDTGH GLRLIHYSYG AGSTEKGDIP DGYKASRPSQ ENFSLILELA TPSQTSVYFC
     ASGELGGFNQ DTQYFGPGTR LLVL
//