Unreviewed, UniProtKB/TrEMBL A2NHL8 (A2NHL8_HUMAN)

Names and origin

Protein names

Submitted name:
    Caspase 4, apoptosis-related cysteine peptidase EMBL ABR09278.1
Submitted name:
    Caspase 4, apoptosis-related cysteine peptidase, isoform CRA_b EMBL EAW67051.1
    Mih1/TX isoform alpha EMBL AAC99850.1

Gene names

Name:	mih1/Tx EMBL AAC99850.1
Synonyms:	CASP4 EMBL EAW67051.1
ORF Names:	hCG_40121 EMBL EAW67051.1

Organism

Homo sapiens (Human) EMBL AAC99850.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the peptidase C14A family. RuleBase RU003971V2 Contains 1 CARD domain. Spearmint SPM001315

Ontologies

Keywords
Molecular function	Hydrolase Protease Thiol protease RuleBase RU003972V1
PTM	Zymogen RuleBase RU003972V1
Gene Ontology (GO)
Uncategorized	caspase activity Inferred from electronic annotation. Source: InterPro
Biological process	proteolysis Inferred from electronic annotation. Source: InterPro regulation of apoptosis Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	A2NHL8-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: DC7CCEC6E9D483EB	FASTA	377	43,262
	10 20 30 40 50 60 MAEGNHRKKP LKVLESLGKD FLTGVLDNLV EQNVLNWKEE EKKKYYDAKT EDKVRVMADS 70 80 90 100 110 120 MQEKQRMAGQ MLLQTFFNID QISPNKKAHP NMEAGPPESG ESTDALKLCP HEEFLRLCKE 130 140 150 160 170 180 RAEEIYPIKE RNNRTRLALI ICNTEFDHLP PRNGADFDIT GMKELLEGLD YSVDVEENLT 190 200 210 220 230 240 ARDMESALRA FATRPEHKSS DSTFLVLMSH GILEGICGTV HDEKKPDVLL YDTIFQIFNN 250 260 270 280 290 300 RNCLSLKDKP KVIIVQACRG ANRGELWVRD SPASLEVASS QSSENLEEDA VYKTHVEKDF 310 320 330 340 350 360 IAFCSSTPHN VSWRDSTMGS IFITQLITCF QKYSWCCHLE EVFRKVQQSF ETPRAKAQMP 370 TIERLSMTRY FYLFPGN

References

[1]	"Cloning of human ICE homolog Mih1." Fernandes-Alnemri T., Litwack G., Alnemri E.S. Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[2]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Rieder M.J., Bertucci C., Stanaway I.B., Johnson E.J., Swanson J.E., Siegel D.L., da Ponte S.H., Igartua C., Patterson K., Nickerson D.A. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U28976 mRNA. Translation: AAC99850.1. EF636667 Genomic DNA. Translation: ABR09278.1. CH471065 Genomic DNA. Translation: EAW67051.1.
IPI	IPI00027725.
RefSeq	NP_001216.1.
UniGene	Hs.138378
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A2NHL8.
Genome annotation databases
Ensembl	ENSG00000196954. Homo sapiens. [Contig view]
GeneID	837.
KEGG	hsa:837.
Organism-specific databases
HGNC	HGNC:1505. CASP4.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	A2NHL8.
OMA	A2NHL8. KLCPHEE.
Gene expression databases
Bgee	A2NHL8.
Family and domain databases
InterPro	IPR001315. CARD. IPR017350. Caspase_IL-1_beta. IPR011029. DEATH-like. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 1 hit.
PANTHER	PTHR10454. Pept_C14_p45. 1 hit.
Pfam	PF00619. CARD. 1 hit. PF00656. Peptidase_C14. 1 hit. [Graphical view]
PIRSF	PIRSF038001. Caspase_ICE. 1 hit.
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00114. CARD. 1 hit. SM00115. CASc. 1 hit. [Graphical view]
PROSITE	PS50209. CARD. 1 hit. PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3484.

Entry information

Entry name

A2NHL8_HUMAN

Accession

Primary (citable) accession number: A2NHL8

Entry history

Integrated into UniProtKB/TrEMBL:	February 20, 2007
Last sequence update:	February 20, 2007
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)