ID   A2N192_HUMAN            Unreviewed;       151 AA.
AC   A2N192;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   SubName: Full=Immunglobulin heavy chain {ECO:0000313|EMBL:AAA03674.2};
DE   Flags: Precursor; Fragment;
GN   Name=IGH@ {ECO:0000313|EMBL:AAA03674.2};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA03674.2};
RN   [1] {ECO:0000313|EMBL:AAA03674.2}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Peripheral blood {ECO:0000313|EMBL:AAA03674.2};
RX   PubMed=9037000;
RA   Schettino E.W., Chai S.K., Kasaian M.T., Schroeder H.W.Jr., Casali P.;
RT   "VHDJH gene sequences and antigen reactivity of monoclonal antibodies
RT   produced by human B-1 cells: evidence for somatic selection.";
RL   J. Immunol. 158:2477-2489(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004370}. Secreted
CC       {ECO:0000256|ARBA:ARBA00004613}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L23571; AAA03674.2; -; mRNA.
DR   AlphaFoldDB; A2N192; -.
DR   PeptideAtlas; A2N192; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019814; C:immunoglobulin complex; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR   CDD; cd04981; IgV_H; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR23266; IMMUNOGLOBULIN HEAVY CHAIN; 1.
DR   PANTHER; PTHR23266:SF241; IMMUNOGLOBULIN HEAVY VARIABLE 3-30-RELATED; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; Immunoglobulin; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW   Immunity {ECO:0000256|ARBA:ARBA00022859};
KW   Immunoglobulin {ECO:0000256|ARBA:ARBA00043265};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136}; Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..151
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002644633"
FT   DOMAIN          29..113
FT                   /note="Ig-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50835"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAA03674.2"
FT   NON_TER         151
FT                   /evidence="ECO:0000313|EMBL:AAA03674.2"
SQ   SEQUENCE   151 AA;  16787 MW;  F0D35001D7EF2176 CRC64;
     LGLCWVFLVA LLRGVLCQVQ LVESGGGVVQ PGRSLRLSCA ASGFTFSSYG MHWVRQAPGK
     GLEWVAVIWY DGSNKYYADS VKGRFTISRD NSKNTLYLQM NSLRAEDTAV YYCARPVLLW
     FREPYNWFDP WGQGTLVTVS SGSASAPTLF P
//