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A2KF29

- SMKTR_MOUSE

UniProt

A2KF29 - SMKTR_MOUSE

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Protein

Sperm motility kinase Tcr mutant form

Gene
Smoktcr
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

While the main function of Smoks is to control sperm motility, the role of Smok-Tcr, with reduced kinase activity, is to counterbalance a signaling impairment caused by the distorter/sterility loci, giving t-sperm an advantage in reaching the oocytes. Transmission ratio distortion also called segregation distortion is the name given to the phenomenon above-mentioned. Being associated with the T-complex, it allows males heterozygous for a complete t-haplotype to preferentially transmit the t-haplotype chromosome.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371ATP By similarity
Active sitei127 – 1271Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi14 – 229ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
  3. protein tyrosine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm motility kinase Tcr mutant form (EC:2.7.11.1)
Short name:
SmokTcr
Short name:
Tcr
Alternative name(s):
Dominant negative form of Smok
Responder protein Smok-Tcr
Gene namesi
Name:Smoktcr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484Sperm motility kinase Tcr mutant formPRO_0000307873Add
BLAST

Proteomic databases

PRIDEiA2KF29.

Expressioni

Tissue specificityi

Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Expressed late in spermiogenesis, only in Tcr-containing t-haplotypes.1 Publication

Gene expression databases

GenevestigatoriA2KF29.

Structurei

3D structure databases

ProteinModelPortaliA2KF29.
SMRiA2KF29. Positions 4-356.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 256249Protein kinaseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

HOVERGENiHBG108494.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2KF29-1 [UniParc]FASTAAdd to Basket

« Hide

MEKFHAQYEM LETIGQGGCA QVKLARHRLT GTHVAVKVIV KRECWFNPVM    50
SEAELLMMTD HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIQNAGYLQ 100
EDEARPLFKQ LLSAMNYCHN QGIVHRDLTP DNIMVEKDGK VKIIDFGLGT 150
QEKPGQNHNL FCEIYPFSTP EVLFNRPYDM RKIDVWGLGV VLYFMVTGKI 200
LFDTASVEKL RKQIVAEKCS VPCRLSVELQ DLIRLLMTDI PELRPTVAEV 250
MVHPWVTEGS GVLPDPCEEH IPLKPDPAIA KAMGFIGFQA QDIEDSLCQR 300
KFNETMASYC LLKKQILKEC DRPIRAQPMN PSVTPLSSLV DAPTFHLGLR 350
RTETEPTGLR LSDNKEVPVC GNSTSKKRER SFSGPGVLSR PINTTPTMDQ 400
THTRTWSGPC IYSNVCTIHP NSINESTEGH ISTSAEDKPV HSRGWPRGIK 450
GWTRKIGNAM RKLCCCIPSK ETSHLGQRRV CPKI 484
Length:484
Mass (Da):54,619
Last modified:February 20, 2007 - v1
Checksum:iA84F3BDCE420C973
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245452 mRNA. Translation: CAB61340.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ245452 mRNA. Translation: CAB61340.1 .

3D structure databases

ProteinModelPortali A2KF29.
SMRi A2KF29. Positions 4-356.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi A2KF29.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG108494.

Miscellaneous databases

NextBioi 35544435.
PROi A2KF29.

Gene expression databases

Genevestigatori A2KF29.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance."
    Herrmann B.G., Koschorz B., Wertz K., McLaughlin K.J., Kispert A.
    Nature 402:141-146(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION.
    Tissue: Testis.

Entry informationi

Entry nameiSMKTR_MOUSE
AccessioniPrimary (citable) accession number: A2KF29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.
T6 allele.

Caution

Although it is derived from a rearrangement with the neighboring RSK3 gene, it plays a crucial role in t-haplotype cells.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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