Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A2KF29

- SMKTR_MOUSE

UniProt

A2KF29 - SMKTR_MOUSE

Protein

Sperm motility kinase Tcr mutant form

Gene

Smoktcr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    While the main function of Smoks is to control sperm motility, the role of Smok-Tcr, with reduced kinase activity, is to counterbalance a signaling impairment caused by the distorter/sterility loci, giving t-sperm an advantage in reaching the oocytes. Transmission ratio distortion also called segregation distortion is the name given to the phenomenon above-mentioned. Being associated with the T-complex, it allows males heterozygous for a complete t-haplotype to preferentially transmit the t-haplotype chromosome.1 Publication

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei37 – 371ATPPROSITE-ProRule annotation
    Active sitei127 – 1271Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi14 – 229ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW
    3. protein tyrosine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sperm motility kinase Tcr mutant form (EC:2.7.11.1)
    Short name:
    SmokTcr
    Short name:
    Tcr
    Alternative name(s):
    Dominant negative form of Smok
    Responder protein Smok-Tcr
    Gene namesi
    Name:Smoktcr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 484484Sperm motility kinase Tcr mutant formPRO_0000307873Add
    BLAST

    Proteomic databases

    PRIDEiA2KF29.

    Expressioni

    Tissue specificityi

    Testis-specific. Expressed in the testis from 22 days postpartum (22 dpp). Expressed late in spermiogenesis, only in Tcr-containing t-haplotypes.1 Publication

    Gene expression databases

    GenevestigatoriA2KF29.

    Structurei

    3D structure databases

    ProteinModelPortaliA2KF29.
    SMRiA2KF29. Positions 4-356.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 256249Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. Smok subfamily.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG108494.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2KF29-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKFHAQYEM LETIGQGGCA QVKLARHRLT GTHVAVKVIV KRECWFNPVM    50
    SEAELLMMTD HPNIISLLQV IETKKKVYLI MELCEGKSLY QHIQNAGYLQ 100
    EDEARPLFKQ LLSAMNYCHN QGIVHRDLTP DNIMVEKDGK VKIIDFGLGT 150
    QEKPGQNHNL FCEIYPFSTP EVLFNRPYDM RKIDVWGLGV VLYFMVTGKI 200
    LFDTASVEKL RKQIVAEKCS VPCRLSVELQ DLIRLLMTDI PELRPTVAEV 250
    MVHPWVTEGS GVLPDPCEEH IPLKPDPAIA KAMGFIGFQA QDIEDSLCQR 300
    KFNETMASYC LLKKQILKEC DRPIRAQPMN PSVTPLSSLV DAPTFHLGLR 350
    RTETEPTGLR LSDNKEVPVC GNSTSKKRER SFSGPGVLSR PINTTPTMDQ 400
    THTRTWSGPC IYSNVCTIHP NSINESTEGH ISTSAEDKPV HSRGWPRGIK 450
    GWTRKIGNAM RKLCCCIPSK ETSHLGQRRV CPKI 484
    Length:484
    Mass (Da):54,619
    Last modified:February 20, 2007 - v1
    Checksum:iA84F3BDCE420C973
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245452 mRNA. Translation: CAB61340.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ245452 mRNA. Translation: CAB61340.1 .

    3D structure databases

    ProteinModelPortali A2KF29.
    SMRi A2KF29. Positions 4-356.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi A2KF29.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG108494.

    Miscellaneous databases

    NextBioi 35544435.
    PROi A2KF29.

    Gene expression databases

    Genevestigatori A2KF29.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008266. Tyr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A protein kinase encoded by the t complex responder gene causes non-Mendelian inheritance."
      Herrmann B.G., Koschorz B., Wertz K., McLaughlin K.J., Kispert A.
      Nature 402:141-146(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, FUNCTION.
      Tissue: Testis.

    Entry informationi

    Entry nameiSMKTR_MOUSE
    AccessioniPrimary (citable) accession number: A2KF29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Encoded on the T-complex, a region of 20-30 Mb on proximal third of mouse chromosome 17. Naturally occurring variant forms of the T-complex, known as complete t-haplotypes, are found in wild mouse populations. The t-haplotypes contain at least four nonoverlapping inversions that suppress recombination with the wild-type chromosome, and lock into strong linkage disequilibrium loci affecting normal transmission of the chromosome, male gametogenesis and embryonic development.
    T6 allele.

    Caution

    Although it is derived from a rearrangement with the neighboring RSK3 gene, it plays a crucial role in t-haplotype cells.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3