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Protein
Submitted name:

R2 protein

Gene

r2

Organism
Lama glama (Llama)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
R2 proteinImported
Gene namesi
Name:r2Imported
OrganismiLama glama (Llama)Imported
Taxonomic identifieri9844 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaTylopodaCamelidaeLama

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi22 ↔ 99Combined sources

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QD0X-ray2.50A1-128[»]
2X89X-ray2.16A/B/C1-128[»]
ProteinModelPortaliA2KD59.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA2KD59.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 110110Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Phylogenomic databases

HOVERGENiHBG018013.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

A2KD59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
QVQLQESGGG LVQAGGSLRL SCAASGRATS GHGHYGMGWF RQVPGKEREF
60 70 80 90 100
VAAIRWSGKE TWYKDSVKGR FTISRDNAKT TVYLQMNSLK PEDTAVYYCA
110 120
ARPVRVDDIS LPVGFDYWGQ GTQVTVSS
Length:128
Mass (Da):14,025
Last modified:February 20, 2007 - v1
Checksum:iF744E00A0CDE35FE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei128 – 1281Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ236100 Genomic DNA. Translation: CAA15412.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ236100 Genomic DNA. Translation: CAA15412.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QD0X-ray2.50A1-128[»]
2X89X-ray2.16A/B/C1-128[»]
ProteinModelPortaliA2KD59.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG018013.

Miscellaneous databases

EvolutionaryTraceiA2KD59.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Camelid heavy-chain variable domains provide efficient combining sites to haptens."
    Spinelli S., Frenken L.G., Hermans P., Verrips T., Brown K., Tegoni M., Cambillau C.
    Biochemistry 39:1217-1222(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS), DISULFIDE BONDS.
  2. "Improved production and function of llama heavy chain antibody fragments by molecular evolution."
    van der Linden R.H.J., de Geus B., Frenken L.G.J., Peters H., Verrips C.T.
    J. Biotechnol. 80:261-270(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Atomic structure of a nanobody-trapped domain-swapped dimer of an amyloidogenic beta2-microglobulin variant."
    Domanska K., Vanderhaegen S., Srinivasan V., Pardon E., Dupeux F., Marquez J.A., Giorgetti S., Stoppini M., Wyns L., Bellotti V., Steyaert J.
    Proc. Natl. Acad. Sci. U.S.A. 108:1314-1319(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.16 ANGSTROMS), DISULFIDE BONDS.

Entry informationi

Entry nameiA2KD59_LAMGL
AccessioniPrimary (citable) accession number: A2KD59
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 11, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.