Serpin A3-5 precursor - Bos taurus (Bovine)

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A2I7N1 (SPA35_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 6, 2013. Version 34. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Serpin A3-5

Gene names

Name:

SERPINA3-5

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Serine protease inhibitor By similarity. UniProtKB Q9TTE1
Subunit structure	Homodimer By similarity. UniProtKB Q9TTE1
Subcellular location	Cytoplasmic vesicle › secretory vesicle › chromaffin granule By similarity. Secreted By similarity UniProtKB Q9TTE1.
Sequence similarities	Belongs to the serpin family.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Secreted
Domain	Signal
Molecular function	Protease inhibitor Serine protease inhibitor
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	chromaffin granule Inferred from electronic annotation. Source: UniProtKB-SubCell cytoplasmic vesicle Inferred from sequence or structural similarity. Source: UniProtKB extracellular space Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	serine-type endopeptidase inhibitor activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

24

By similarity

Chain

387

Serpin A3-5

PRO_0000401159

Sites

Site

2

Reactive bond By similarity UniProtKB Q9TTE1

Amino acid modifications

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Glycosylation

1

N-linked (GlcNAc...) Potential

Sequences

Sequence

Length

Mass (Da)

Tools

A2I7N1 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 09CC2860390D7004
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411

46,397

        10         20         30         40         50         60 
MRAERTSFLL ALGLLMAGIR SVHCLPENVV VKDQRRRVDS HTLASSNTDF AFSLYKQLAL 

        70         80         90        100        110        120 
KNPNKNVMFS PLSVSMALAF LSLGARGPTL TEILEGLKFN LTEIQETQIH QGFQHLLQAL 

       130        140        150        160        170        180 
NRPSNQLQLS VGNAMFVQEE LKLLDKFIED ARVLYSSEAF PTNFRDSEAA RSLINDYVKN 

       190        200        210        220        230        240 
KTQGKIEELF KYLSPRTVLV LVNYIYFKAQ WKTRFDPKHT EQAEFHVSKN KTVEVPMMTL 

       250        260        270        280        290        300 
DLETPYFRDK ELGCMLVELT YSSNDSALFI LPDEGKMQDL EAKLTPETLT RWRNSLQPRR 

       310        320        330        340        350        360 
IHELYLPKFS IKSNYELNDT LSQMGIKKIF TDADLSGITG TADLVVSQVV HGAALDVDEE 

       370        380        390        400        410 
GTEGAAATGI GIERTFLRII VRVNRPFLIA VVLKDTQSII FLGKVTNPSE A

References

[1]

"An original SERPINA3 gene cluster: elucidation of genomic organization and gene expression in the Bos taurus 21q24 region."
Pelissier P., Delourme D., Germot A., Blanchet X., Becila S., Maftah A., Leveziel H., Ouali A., Bremaud L.
BMC Genomics 9:151-151(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EF153628 Genomic DNA. Translation: ABM55498.1.
IPI	IPI00707034.
RefSeq	NP_001075213.1. NM_001081744.1.
UniGene	Bt.55387.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	A2I7N1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	617667.
KEGG	bta:617667.
Organism-specific databases
CTD	12.
Phylogenomic databases
HOVERGEN	HBG005957.
InParanoid	A2I7N1.
KO	K04525.
Family and domain databases
InterPro	IPR023795. Protease_inhib_I4_serpin_CS. IPR023796. Serpin_dom. IPR000215. Serpin_fam. [Graphical view]
PANTHER	PTHR11461. PTHR11461. 1 hit.
Pfam	PF00079. Serpin. 1 hit. [Graphical view]
SMART	SM00093. SERPIN. 1 hit. [Graphical view]
SUPFAM	SSF56574. Prot_inh_serpin. 1 hit.
PROSITE	PS00284. SERPIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20900782.

Entry information

Entry name

SPA35_BOVIN

Accession

Primary (citable) accession number: A2I7N1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	February 20, 2007
Last modified:	March 6, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents