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Protein

Serpin A3-5

Gene

SERPINA3-5

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Serine protease inhibitor.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei377 – 3782Reactive bondBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.027.

Names & Taxonomyi

Protein namesi
Recommended name:
Serpin A3-5
Gene namesi
Name:SERPINA3-5Imported
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Cytoplasmic vesiclesecretory vesiclechromaffin granule By similarity
  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 411387Serpin A3-5Sequence analysisPRO_0000401159Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi100 – 1001N-linked (GlcNAc...)Sequence analysis
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Glycosylationi230 – 2301N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiA2I7N1.
PeptideAtlasiA2I7N1.
PRIDEiA2I7N1.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009264.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOVERGENiHBG005957.
InParanoidiA2I7N1.
KOiK04525.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2I7N1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAERTSFLL ALGLLMAGIR SVHCLPENVV VKDQRRRVDS HTLASSNTDF
60 70 80 90 100
AFSLYKQLAL KNPNKNVMFS PLSVSMALAF LSLGARGPTL TEILEGLKFN
110 120 130 140 150
LTEIQETQIH QGFQHLLQAL NRPSNQLQLS VGNAMFVQEE LKLLDKFIED
160 170 180 190 200
ARVLYSSEAF PTNFRDSEAA RSLINDYVKN KTQGKIEELF KYLSPRTVLV
210 220 230 240 250
LVNYIYFKAQ WKTRFDPKHT EQAEFHVSKN KTVEVPMMTL DLETPYFRDK
260 270 280 290 300
ELGCMLVELT YSSNDSALFI LPDEGKMQDL EAKLTPETLT RWRNSLQPRR
310 320 330 340 350
IHELYLPKFS IKSNYELNDT LSQMGIKKIF TDADLSGITG TADLVVSQVV
360 370 380 390 400
HGAALDVDEE GTEGAAATGI GIERTFLRII VRVNRPFLIA VVLKDTQSII
410
FLGKVTNPSE A
Length:411
Mass (Da):46,397
Last modified:February 20, 2007 - v1
Checksum:i09CC2860390D7004
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF153628 Genomic DNA. Translation: ABM55498.1.
RefSeqiNP_001075213.1. NM_001081744.1.
UniGeneiBt.55387.

Genome annotation databases

GeneIDi617667.
KEGGibta:617667.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF153628 Genomic DNA. Translation: ABM55498.1.
RefSeqiNP_001075213.1. NM_001081744.1.
UniGeneiBt.55387.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009264.

Protein family/group databases

MEROPSiI04.027.

Proteomic databases

PaxDbiA2I7N1.
PeptideAtlasiA2I7N1.
PRIDEiA2I7N1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi617667.
KEGGibta:617667.

Organism-specific databases

CTDi12.

Phylogenomic databases

eggNOGiKOG2392. Eukaryota.
COG4826. LUCA.
HOVERGENiHBG005957.
InParanoidiA2I7N1.
KOiK04525.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSPA35_BOVIN
AccessioniPrimary (citable) accession number: A2I7N1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: February 20, 2007
Last modified: July 6, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.