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Protein
Submitted name:

Neuronal PAS domain protein 2

Gene

NPAS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation
Biological processTranscription, Transcription regulationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Neuronal PAS domain protein 2Imported
Gene namesi
Name:NPAS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000170485.16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31696

Expressioni

Gene expression databases

BgeeiENSG00000170485
ExpressionAtlasiA2I2P5 baseline and differential
GenevisibleiA2I2P5 HS

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliA2I2P5
SMRiA2I2P5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 59BHLHInterPro annotationAdd BLAST51
Domaini82 – 145PASInterPro annotationAdd BLAST64
Domaini260 – 307PASInterPro annotationAdd BLAST48

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili506 – 526Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation

Phylogenomic databases

eggNOGiENOG410IQ5V Eukaryota
ENOG410Y7Z8 LUCA
HOVERGENiHBG050997
KOiK09026
OMAiFLKEMCI
OrthoDBiEOG091G11CV
PhylomeDBiA2I2P5

Family and domain databases

CDDicd00083 HLH, 1 hit
cd00130 PAS, 2 hits
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR001067 Nuc_translocat
IPR001610 PAC
IPR000014 PAS
IPR035965 PAS-like_dom_sf
IPR013767 PAS_fold
PfamiView protein in Pfam
PF00010 HLH, 1 hit
PF00989 PAS, 1 hit
PRINTSiPR00785 NCTRNSLOCATR
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SM00086 PAC, 1 hit
SM00091 PAS, 2 hits
SUPFAMiSSF47459 SSF47459, 1 hit
SSF55785 SSF55785, 2 hits
TIGRFAMsiTIGR00229 sensory_box, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS50112 PAS, 2 hits

Sequencei

Sequence statusi: Complete.

A2I2P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDEDEKDRAK RASRNKSEKK RRDQFNVLIK ELSSMLPGNT RKMDKTTVLE
60 70 80 90 100
KVIGFLQKHN EVSAQTEICD IQQDWKPSFL SNEEFTQLML EALDGFIIAV
110 120 130 140 150
TTDGSIIYVS DSITPLLGHL PSDVMDQNLL NFLPEQEHSE VYKILSSHML
160 170 180 190 200
VTDSPSPEYL KSDSDLEFYC HLLRGSLNPK EFPTYEYIKF VGNFRSYNNV
210 220 230 240 250
PSPSCNGFDN TLSRPCRVPL GKEVCFIATV RLATPQFLKE MCIVDEPLEE
260 270 280 290 300
FTSRHSLEWK FLFLDHRAPP IIGYLPFEVL GTSGYDYYHI DDLELLARCH
310 320 330 340 350
QHLMQFGKGK SCCYRFLTKG QQWIWLQTHY YITYHQWNSK PEFIVCTHSV
360 370 380 390 400
VSYADVRVER RQELALEDPP SEALHSSALK DKGSSLEPRQ HFNTLDVGAS
410 420 430 440 450
GLNTSHSPSA SSRSSHKSSH TAMSEPTSTP TKLMAEASTP ALPRSATLPQ
460 470 480 490 500
ELPVPGLSQA ATMPAPLPSP SSCDLTQQLL PQTVLQSTPA PMAQFSAQFS
510 520 530 540 550
MFQTIKDQLE QRTRILQANI RWQQEELHKI QEQLCLVQDS NVQMFLQQPA
560 570 580 590 600
VSLSFSSTQR PEAQQQLQQR SAAVTQPQLG AGPQLPGQIS SAQVTSQHLL
610 620 630 640 650
RESSVISTQG PKPMRSSQLM QSSGRSGSSL VSPFSSATAA LPPSLNLTTP
660 670 680 690 700
ASTSQDASQC QPSPDFSHDR QLRLLLSQPI QPMMPGSCDA RQPSEVSRTG
710 720 730 740 750
RQVKYAQSQT VFQNPDAHPA NSSSAPMPVL LMGQAVLHPS FPASQPSPLQ
760 770 780 790 800
PAQARQQPPQ HYLQVQAPTS LHSEQQDSLL LSTYSQQPGT LGYPQPPPAQ
810 820
PQPLRPPRRV SSLSESSGLQ QPPR
Length:824
Mass (Da):91,791
Last modified:February 20, 2007 - v1
Checksum:i679919FCDD3AFDEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF015903 Genomic DNA Translation: ABM64214.1
RefSeqiNP_002509.2, NM_002518.3
UniGeneiHs.156832
Hs.705895

Genome annotation databases

GeneIDi4862
KEGGihsa:4862

Similar proteinsi

Entry informationi

Entry nameiA2I2P5_HUMAN
AccessioniPrimary (citable) accession number: A2I2P5
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: May 23, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Main funding by: National Institutes of Health