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Protein

Alpha-amylase

Gene

TVAG_537410

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1->4)-alpha-linked D-glucose units.UniRule annotation

GO - Molecular functioni

  1. alpha-amylase activity Source: UniProtKB-EC
  2. cation binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotation, Hydrolase

Keywords - Biological processi

Carbohydrate metabolismUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-amylaseUniRule annotation (EC:3.2.1.1UniRule annotation)
Gene namesi
ORF Names:TVAG_537410Imported
OrganismiTrichomonas vaginalisImported
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
ProteomesiUP000001542: Unassembled WGS sequence

Organism-specific databases

EuPathDBiTrichDB:TVAG_537410.

Interactioni

Protein-protein interaction databases

STRINGi5722.A2GAK8.

Structurei

3D structure databases

ProteinModelPortaliA2GAK8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 13 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0366.
InParanoidiA2GAK8.
KOiK01176.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
PRINTSiPR00110. ALPHAAMYLASE.
SUPFAMiSSF51445. SSF51445. 2 hits.

Sequencei

Sequence statusi: Complete.

A2GAK8-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MLISFAVNGR FGAANQYDPL PNCNIHPQMS CAGSSGDIDP KWFGNLWNTP
60 70 80 90 100
KRGKENWKPG FQDMSDLTGY AQLKYASGRQ SCTVNIITKT SKDLDLTFYF
110 120 130 140 150
DGVAQKTNSK TFDSSFNKLL KVKVVAATGE SLILDDIDFV RNVAPLGQRS
160 170 180 190 200
NDQRYRNGQK GAIIELFGWP DADIEQECKF IADAGYLGVK VFPHQEQVMS
210 220 230 240 250
SQTFEKELNP WYFMYQPVSY RLQGRMGTRD QLRNMINTCR RYGVRVYADA
260 270 280 290 300
VVNHMTGNGN DLSNHRNPSA GCTKWGNKTS SAYELGSPYY TPAYTYETNP
310 320 330 340 350
NTGRGTNVLE FPAVPYGPED FHCDKALGSW SDPNILNTGW LSGLSDLDTS
360 370 380 390 400
KDYVRQRIAD FMIDLISIGF SGYRIDAAKH IHPKDLAAIF GKVKQGLGGS
410 420 430 440 450
LPDDFISWLE VLTGGEAYLL VQGDGDYSFT GGLTKFLKQN GLNDDEILKI
460 470 480 490 500
KIWWCGYPTE PGNDNGSIDP HRKVIQNDDH DQQNDGSSSR DMHDAGCVLV
510 520 530 540 550
KGCDPAKHRE YEKRLFKNPA GFESNNKDAA PIRLVLSSYY WGDNNVHSIP
560 570 580 590 600
DGESDCKKCT LSCESCHTRE YIKAYNPSAT SYPGGKGYTY VHRDSEIIQE

MNNWMNL
Length:607
Mass (Da):67,968
Last modified:February 20, 2007 - v1
Checksum:i50CCA42F30793DE2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS114826 Genomic DNA. Translation: EAX85812.1.
RefSeqiXP_001298742.1. XM_001298741.1.

Genome annotation databases

GeneIDi4743455.
KEGGitva:TVAG_537410.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS114826 Genomic DNA. Translation: EAX85812.1.
RefSeqiXP_001298742.1. XM_001298741.1.

3D structure databases

ProteinModelPortaliA2GAK8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5722.A2GAK8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4743455.
KEGGitva:TVAG_537410.

Organism-specific databases

EuPathDBiTrichDB:TVAG_537410.

Phylogenomic databases

eggNOGiCOG0366.
InParanoidiA2GAK8.
KOiK01176.

Family and domain databases

Gene3Di3.20.20.80. 2 hits.
InterProiIPR006046. Alpha_amylase.
IPR015902. Glyco_hydro_13.
IPR006047. Glyco_hydro_13_cat_dom.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10357. PTHR10357. 1 hit.
PfamiPF00128. Alpha-amylase. 1 hit.
[Graphical view]
PRINTSiPR00110. ALPHAAMYLASE.
SUPFAMiSSF51445. SSF51445. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
    Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
    , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
    Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-98 / G3Imported.

Entry informationi

Entry nameiA2GAK8_TRIVA
AccessioniPrimary (citable) accession number: A2GAK8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: January 7, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.