ID   A2EXA5_TRIV3            Unreviewed;       486 AA.
AC   A2EXA5;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 93.
DE   SubName: Full=SET domain containing protein {ECO:0000313|EMBL:EAY02704.1};
GN   ORFNames=TVAG_440830 {ECO:0000313|EMBL:EAY02704.1};
OS   Trichomonas vaginalis (strain ATCC PRA-98 / G3).
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=412133 {ECO:0000313|EMBL:EAY02704.1, ECO:0000313|Proteomes:UP000001542};
RN   [1] {ECO:0000313|EMBL:EAY02704.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=G3 {ECO:0000313|EMBL:EAY02704.1};
RA   Amadeo P., Zhao Q., Wortman J., Fraser-Liggett C., Carlton J.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAY02704.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G3 {ECO:0000313|EMBL:EAY02704.1};
RX   PubMed=17218520; DOI=10.1126/science.1132894;
RA   Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA   Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA   Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA   Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D., Mueller S.,
RA   Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D.,
RA   Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y.,
RA   Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M.,
RA   Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J.,
RA   Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B.,
RA   Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A.,
RA   Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S.,
RA   Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA   Johnson P.J.;
RT   "Draft genome sequence of the sexually transmitted pathogen Trichomonas
RT   vaginalis.";
RL   Science 315:207-212(2007).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; DS113527; EAY02704.1; -; Genomic_DNA.
DR   RefSeq; XP_001314927.1; XM_001314892.1.
DR   AlphaFoldDB; A2EXA5; -.
DR   STRING; 5722.A2EXA5; -.
DR   GeneID; 4760540; -.
DR   KEGG; tva:TVAG_2v0765810; -.
DR   VEuPathDB; TrichDB:TVAG_440830; -.
DR   VEuPathDB; TrichDB:TVAGG3_0765810; -.
DR   eggNOG; KOG1080; Eukaryota.
DR   InParanoid; A2EXA5; -.
DR   Proteomes; UP000001542; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0042800; F:histone H3K4 methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd10518; SET_SETD1-like; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR003616; Post-SET_dom.
DR   InterPro; IPR044570; Set1-like.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   PANTHER; PTHR45814; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR   PANTHER; PTHR45814:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETD1; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00508; PostSET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS50868; POST_SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001542};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          286..408
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   DOMAIN          416..432
FT                   /note="Post-SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50868"
FT   REGION          1..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          240..267
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        23..51
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        58..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        83..160
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   486 AA;  56753 MW;  DC0916EA13F4D7A9 CRC64;
     MMMNKRIRPQ RRHSSSDSLD NPSSYDEDER KKSFSNRMTN REDKSEIKTP TRSDSPKVMN
     HNNKEDKKEV IRSRSKNIQQ NSEMRVTREH IRHENADHPS QIEKRERFEN HRRPNRENKD
     LRVKIDIGDR KTTSHDHQRE KKEKSSKIIP QNEKPKEPKI KFEKPSIPVP QITKKVKKET
     DNINLPLPPP QIPPETEDIK PAVISRPKAQ LVTGKIPKCS RIVPIKCLSF KKRDKYYRAA
     NANRKQLDII EETLKDEERQ NQKFYQLLSS FKGANSDLIS VELDTKDMKL NYIRFEKSKI
     EGFGVKTTIP IRKGEKVIEY IGEVIRPIIA DKRQINYEKM GNHGTYVFKA DSDHYLDATF
     RGGIARWINH SCDPNCESRI IKLNGRFAVV LVAIKDINPC EELTYDYKLP YEPEDKAIKC
     LCGSPNCRGW LNRDKNTLDD KTFSEVKFKN ISEDVLLRLV ENNILPIDLF KADGEFYVSH
     IDKDGN
//