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Protein

Histone-lysine N-methyltransferase

Gene

TVAG_440830

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
ORF Names:TVAG_440830Imported
OrganismiTrichomonas vaginalisImported
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
ProteomesiUP000001542 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiTrichDB:TVAG_440830.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi5722.A2EXA5.

Family & Domainsi

Sequence similaritiesi

Contains 1 post-SET domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiA2EXA5.
KOiK11422.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2EXA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMNKRIRPQ RRHSSSDSLD NPSSYDEDER KKSFSNRMTN REDKSEIKTP
60 70 80 90 100
TRSDSPKVMN HNNKEDKKEV IRSRSKNIQQ NSEMRVTREH IRHENADHPS
110 120 130 140 150
QIEKRERFEN HRRPNRENKD LRVKIDIGDR KTTSHDHQRE KKEKSSKIIP
160 170 180 190 200
QNEKPKEPKI KFEKPSIPVP QITKKVKKET DNINLPLPPP QIPPETEDIK
210 220 230 240 250
PAVISRPKAQ LVTGKIPKCS RIVPIKCLSF KKRDKYYRAA NANRKQLDII
260 270 280 290 300
EETLKDEERQ NQKFYQLLSS FKGANSDLIS VELDTKDMKL NYIRFEKSKI
310 320 330 340 350
EGFGVKTTIP IRKGEKVIEY IGEVIRPIIA DKRQINYEKM GNHGTYVFKA
360 370 380 390 400
DSDHYLDATF RGGIARWINH SCDPNCESRI IKLNGRFAVV LVAIKDINPC
410 420 430 440 450
EELTYDYKLP YEPEDKAIKC LCGSPNCRGW LNRDKNTLDD KTFSEVKFKN
460 470 480
ISEDVLLRLV ENNILPIDLF KADGEFYVSH IDKDGN
Length:486
Mass (Da):56,753
Last modified:February 20, 2007 - v1
Checksum:iDC0916EA13F4D7A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS113527 Genomic DNA. Translation: EAY02704.1.
RefSeqiXP_001314927.1. XM_001314892.1.

Genome annotation databases

GeneIDi4760540.
KEGGitva:TVAG_440830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS113527 Genomic DNA. Translation: EAY02704.1.
RefSeqiXP_001314927.1. XM_001314892.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5722.A2EXA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi4760540.
KEGGitva:TVAG_440830.

Organism-specific databases

EuPathDBiTrichDB:TVAG_440830.

Phylogenomic databases

eggNOGiCOG2940.
InParanoidiA2EXA5.
KOiK11422.

Family and domain databases

InterProiIPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
    Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
    , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
    Science 315:207-212(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-98 / G3Imported.

Entry informationi

Entry nameiA2EXA5_TRIVA
AccessioniPrimary (citable) accession number: A2EXA5
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 4, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.