ID   A2ERV5_TRIV3            Unreviewed;      1664 AA.
AC   A2ERV5;
DT   20-FEB-2007, integrated into UniProtKB/TrEMBL.
DT   20-FEB-2007, sequence version 1.
DT   27-MAR-2024, entry version 79.
DE   SubName: Full=BRCA2 repeat family protein {ECO:0000313|EMBL:EAY04622.1};
GN   ORFNames=TVAG_473090 {ECO:0000313|EMBL:EAY04622.1};
OS   Trichomonas vaginalis (strain ATCC PRA-98 / G3).
OC   Eukaryota; Metamonada; Parabasalia; Trichomonadida; Trichomonadidae;
OC   Trichomonas.
OX   NCBI_TaxID=412133 {ECO:0000313|EMBL:EAY04622.1, ECO:0000313|Proteomes:UP000001542};
RN   [1] {ECO:0000313|EMBL:EAY04622.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=G3 {ECO:0000313|EMBL:EAY04622.1};
RA   Amadeo P., Zhao Q., Wortman J., Fraser-Liggett C., Carlton J.;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EAY04622.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G3 {ECO:0000313|EMBL:EAY04622.1};
RX   PubMed=17218520; DOI=10.1126/science.1132894;
RA   Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q.,
RA   Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S.,
RA   Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C.,
RA   Van de Peer Y., Miranda-Saavedra D., Barton G.J., Westrop G.D., Mueller S.,
RA   Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D.,
RA   Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y.,
RA   Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M.,
RA   Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J.,
RA   Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B.,
RA   Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A.,
RA   Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S.,
RA   Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M.,
RA   Johnson P.J.;
RT   "Draft genome sequence of the sexually transmitted pathogen Trichomonas
RT   vaginalis.";
RL   Science 315:207-212(2007).
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DR   EMBL; DS113470; EAY04622.1; -; Genomic_DNA.
DR   RefSeq; XP_001316845.1; XM_001316810.1.
DR   SMR; A2ERV5; -.
DR   STRING; 5722.A2ERV5; -.
DR   GeneID; 4762485; -.
DR   KEGG; tva:TVAG_2v0019940; -.
DR   VEuPathDB; TrichDB:TVAG_473090; -.
DR   VEuPathDB; TrichDB:TVAGG3_0019940; -.
DR   eggNOG; KOG4751; Eukaryota.
DR   InParanoid; A2ERV5; -.
DR   OMA; GLCKHAG; -.
DR   Proteomes; UP000001542; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 3.
DR   InterPro; IPR015525; BRCA2.
DR   InterPro; IPR015252; BRCA2_hlx.
DR   InterPro; IPR036315; BRCA2_hlx_sf.
DR   InterPro; IPR015187; BRCA2_OB_1.
DR   InterPro; IPR002093; BRCA2_repeat.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   PANTHER; PTHR11289:SF0; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN; 1.
DR   PANTHER; PTHR11289; BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2; 1.
DR   Pfam; PF09169; BRCA-2_helical; 1.
DR   Pfam; PF09103; BRCA-2_OB1; 1.
DR   SUPFAM; SSF81872; BRCA2 helical domain; 1.
DR   SUPFAM; SSF50249; Nucleic acid-binding proteins; 2.
DR   PROSITE; PS50138; BRCA2_REPEAT; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001542};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          894..964
FT                   /note="Breast cancer type 2 susceptibility protein helical"
FT                   /evidence="ECO:0000259|Pfam:PF09169"
FT   DOMAIN          970..1076
FT                   /note="BRCA2 OB1"
FT                   /evidence="ECO:0000259|Pfam:PF09103"
FT   REGION          34..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          533..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          600..770
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          783..833
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          339..366
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        48..65
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..121
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..155
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        156..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..227
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        600..653
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..704
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..723
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..770
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        783..831
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1664 AA;  188998 MW;  C310B85C35091FCA CRC64;
     MDEQTYSIDK LVSLYNETSE PNWATDASNV ACDPHTPISN YDFPPSIDVA EENHKEYEEN
     EDCNASKQDS SNFSAKQNEN QDTDNSTNNH NDTQRDSLQS NNINDAITEK NEEKTNEENI
     SKETDQNSNL TEETTDLQQN HTDSTEFTNE KLEISNQNAE IKEETEQNNE NTDENNKEEK
     FIGFMTASGK KPLTPSEDSL KKAQKLLENN KNIANESIST NQKEITAKFD ESNQDSKEIP
     NENTNNEQLN DKNQFLGFTT ANGKKSIVPS EESMKKAKNL MKSAEIEREN QFVGFTTANG
     KKSLNPSEES MKRAQNMFNN DENQNQFVGF TTASGKKYLQ PSKESLRKAE NLMKSAEEEF
     KGFTTAIGKR NLNPSEDALR KAQNMFSDNN EQQFVGFTTA NGKKPIIPSE ESMKKAQQIM
     DNAREESKQE FVGFSTANGK KSLIPSEESL RKAENLMKSA EIESEKQFVG FTTANGKKSL
     NSSEDSLRKV QGMFNVNNEQ QFIGFSTANG KKPIVPSEES LRRAQQIMNA AEQESKQEFA
     GFSTANGKKS LMPSEESLRK VQNIFNDNNN EQQFSGFSTA NGKKPIIPSE ASIRRAQQIM
     DSAENESKQE FSGFSTANGK RSLNPSEESL RKAQNIFNDS NEQQFSGFST ANGKKALVPS
     EESMKKAQQI MNDAEQESKQ QFSGFSTANG KKSLNPSEES LRKAQSIMDS AEKEYELKRT
     PKTSISKNSE IPLPSFDDLS QRSSQSSAVL RTPNRTTFLA SPSPSSFKFS PSGMALSNYV
     GNSAMATPTK PKPTSTLVTS QSNRNSQTPQ GKKPFKPPTM TSKTAPVTPM KSDTKTIAKP
     DRLVTVFEMP NNIRRETLKE YSKYKGVPKR EYDPMEFTSD DALNYRFPPP DYRGVNDIYV
     ALLEKNVDPL LLKPSWVRNH YKWIVWKLKC LDLSYKEINQ QNNEQILTFD NVLSEMLFRI
     QREIYEAKRS SLKLIHERDA PPNLFIILAV SKILDDGLIE LTDGWYSIQG ALDINLNKLL
     KEGKINVGDK LRICNATLDG EDACDPLESK ANSTRLMMRM NSVRRAKWYE SLGFQKIALF
     PVNIRSLVGN GGLVPYIEVI IQKKLPLLFR ESKSDGTSVV RNQTLQNIYE RERENQLQND
     LEKARIQWSK ELEEDGTDSL NECPKLKIYL KSDNPSLYLN SLQNDDRKEL EFYIKKHEKE
     VDEFYRNYTE EFMKDYKTES TPFFTVLCTD LCPFKNNDCE VTFWRPSLEL FDTLQEGLCV
     RIYHLGSSET RGNRLTSKGN PHIDILSPQP KLSRFLFRPR HVFENFSELW RFGKIGLSTG
     TFVDINGFAL MSENNCLFVV DGSAVLTCIE ARLSKPEDIL NLNGFVTIEN LKYQSLDDSS
     GIILLLANES TVFNRSPNKQ NRFIWDYFQN VVKPGIDFKK YSKFMKRIIL GQRTKLNHQI
     SDLTVSKPLS SILTFLPFDK IEFAKKDDKH IVFFGLTGDE NSIDNLTNND YFVSGLNLMM
     KVTDGIGTSF LRINALIIYK FFVSFSTQIS NSMRRKLTKF YDDFFSQKDE KDILGHVRSK
     ILENFQIDTN SIETVTRVLI YHGYICYDEK TAKNLLTKIA VSPVFPFRAE EWMNFSVLLS
     DALTECEFSV EYFSGDNGDN IVINASSIGA VDNKTSIKSL MESF
//