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A2E498

- A2E498_TRIVA

UniProt

A2E498 - A2E498_TRIVA

Protein

Branched-chain-amino-acid aminotransferase

Gene

TVAG_139240

Organism
Trichomonas vaginalis
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
    L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
    L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. L-isoleucine transaminase activity Source: UniProtKB-EC
    2. L-leucine transaminase activity Source: UniProtKB-EC
    3. L-valine transaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. branched-chain amino acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AminotransferaseUniRule annotation, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
    Gene namesi
    ORF Names:TVAG_139240Imported
    OrganismiTrichomonas vaginalisImported
    Taxonomic identifieri5722 [NCBI]
    Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
    ProteomesiUP000001542: Unassembled WGS genome

    Organism-specific databases

    EuPathDBiTrichDB:TVAG_139240.

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei184 – 1841N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi5722.A2E498.

    Structurei

    3D structure databases

    ProteinModelPortaliA2E498.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0115.
    KOiK00826.

    Family and domain databases

    InterProiIPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005786. B_amino_transII.
    [Graphical view]
    PANTHERiPTHR11825. PTHR11825. 1 hit.
    PfamiPF01063. Aminotran_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006468. BCAT1. 1 hit.
    SUPFAMiSSF56752. SSF56752. 1 hit.
    TIGRFAMsiTIGR01123. ilvE_II. 1 hit.
    PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2E498-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQPENIDWKT LGFGYVQTEW RYIAHWKDGK WDEGKLVDTP MLTIHEGSTA    50
    LHYGQECFEG LKAYRCKDGS INLFRPDQNA LRMQKSCTRL MMPHVSVEMF 100
    IDACRKVVKA NEKWLAPYGT GASLYLRPFM IGVGANLGVK PAPEYIFSVF 150
    CSPVGAYFKG GLKPTNFIVT TYDRAAPQGT GAAKVGGNYA ASLLPGFDAH 200
    DKKYGDCIYL DPATHTYIEE VGSANFFGIT KDNKFITPLS PSILPSITKY 250
    SLLHLAKERL GMEAIEGSIR IDSLDQFKEA GACGTAAVIS PIGGIKYGDK 300
    FHVFFSETEV GPITQKLYNE LVGIQYGDIP APEGWIVKV 339
    Length:339
    Mass (Da):37,438
    Last modified:February 20, 2007 - v1
    Checksum:iBBE3CADDAF07186C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS113300 Genomic DNA. Translation: EAY12544.1.
    RefSeqiXP_001324767.1. XM_001324732.1.

    Genome annotation databases

    GeneIDi4770510.
    KEGGitva:TVAG_139240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS113300 Genomic DNA. Translation: EAY12544.1 .
    RefSeqi XP_001324767.1. XM_001324732.1.

    3D structure databases

    ProteinModelPortali A2E498.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5722.A2E498.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 4770510.
    KEGGi tva:TVAG_139240.

    Organism-specific databases

    EuPathDBi TrichDB:TVAG_139240.

    Phylogenomic databases

    eggNOGi COG0115.
    KOi K00826.

    Family and domain databases

    InterProi IPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005786. B_amino_transII.
    [Graphical view ]
    PANTHERi PTHR11825. PTHR11825. 1 hit.
    Pfami PF01063. Aminotran_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006468. BCAT1. 1 hit.
    SUPFAMi SSF56752. SSF56752. 1 hit.
    TIGRFAMsi TIGR01123. ilvE_II. 1 hit.
    PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
      Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
      , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
      Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC PRA-98 / G3Imported.

    Entry informationi

    Entry nameiA2E498_TRIVA
    AccessioniPrimary (citable) accession number: A2E498
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 20, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3