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A2DFX6

- A2DFX6_TRIVA

UniProt

A2DFX6 - A2DFX6_TRIVA

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Protein
DNA ligase
Gene
TVAG_162990
Organism
Trichomonas vaginalis
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TVAG_162990Imported
OrganismiTrichomonas vaginalis
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
ProteomesiUP000001542: Unassembled WGS genome

Organism-specific databases

EuPathDBiTrichDB:TVAG_162990.

Interactioni

Protein-protein interaction databases

STRINGi5722.A2DFX6.

Structurei

3D structure databases

ProteinModelPortaliA2DFX6.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2DFX6-1 [UniParc]FASTAAdd to Basket

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MTQQGIAKFF GGKDIESTKK NAIVRKQVNV NISDFDNVFK DVEIPTVEGY    50
NIPRDVVGYV AWNRGDPIPF TFITKMVDEL EPLTGKLEIN DLLCKYFLAI 100
LMTTPKDIVP FVFLCLGQLR PNHEGVKINI GQESIISALG DKKVVKEKLK 150
KEGDLSKVAQ QIRSTQKSMT SMFGKVNEAY TITGVYKEFL KMAGFQGANS 200
DRNRTQTIQK LLTNCKPEEV KCIVRMLECK LRVGAAHESF LFALGMAFRR 250
REYIMGMIKN NPDEEDLKDH GHLFREIYYR YPIIDEILVE FLRGSFKGAE 300
KNINIKVGIP AMPMLAKPAK KLDEIKRRLG DGRITGEYKY DGERAQIHKN 350
KEGKVRIFSR SAEDSTAKFA DVADIITDNV KGEQYILDSE IVAYDPEKHV 400
ILPFQTLMNR PKKGTDTPSA IHVCVCAFDL LSYNGVSMLD EPLEKRRDKL 450
HEIVTVVPTK LQLATYKNAS KIEDLGDFFE EAVSNRTEGL MVKTLNGRYE 500
CGKRAMSWAK LKKDYISKEV FKGGVAEEIP PDTIDVVVIG ATYGKGKRTS 550
VYGAFLVGVY NNVTGKVESL CFVGTGFKED DLKEFYEKLH PLEMEKCPDN 600
VDCRPLDQDP VFFKPELVWE IQVADIQTTP TYSACWGELG EKGLTIRFGR 650
YYRTRTDKTW EQSTSTEQLL ELYHQQFEK 679
Length:679
Mass (Da):77,200
Last modified:February 20, 2007 - v1
Checksum:iD0BDA8ADE832366C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113196 Genomic DNA. Translation: EAY20603.1.
RefSeqiXP_001581589.1. XM_001581539.1.

Genome annotation databases

GeneIDi5466150.
KEGGitva:TVAG_162990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113196 Genomic DNA. Translation: EAY20603.1 .
RefSeqi XP_001581589.1. XM_001581539.1.

3D structure databases

ProteinModelPortali A2DFX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5722.A2DFX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5466150.
KEGGi tva:TVAG_162990.

Organism-specific databases

EuPathDBi TrichDB:TVAG_162990.

Phylogenomic databases

eggNOGi COG1793.
KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
    Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
    , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
    Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-98 / G3.

Entry informationi

Entry nameiA2DFX6_TRIVA
AccessioniPrimary (citable) accession number: A2DFX6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 16, 2013
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3