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A2DFX6

- A2DFX6_TRIVA

UniProt

A2DFX6 - A2DFX6_TRIVA

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Protein

DNA ligase

Gene

TVAG_162990

Organism
Trichomonas vaginalis
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
ORF Names:TVAG_162990Imported
OrganismiTrichomonas vaginalisImported
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
ProteomesiUP000001542: Unassembled WGS genome

Organism-specific databases

EuPathDBiTrichDB:TVAG_162990.

Interactioni

Protein-protein interaction databases

STRINGi5722.A2DFX6.

Structurei

3D structure databases

ProteinModelPortaliA2DFX6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiA2DFX6.
KOiK10747.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2DFX6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQQGIAKFF GGKDIESTKK NAIVRKQVNV NISDFDNVFK DVEIPTVEGY
60 70 80 90 100
NIPRDVVGYV AWNRGDPIPF TFITKMVDEL EPLTGKLEIN DLLCKYFLAI
110 120 130 140 150
LMTTPKDIVP FVFLCLGQLR PNHEGVKINI GQESIISALG DKKVVKEKLK
160 170 180 190 200
KEGDLSKVAQ QIRSTQKSMT SMFGKVNEAY TITGVYKEFL KMAGFQGANS
210 220 230 240 250
DRNRTQTIQK LLTNCKPEEV KCIVRMLECK LRVGAAHESF LFALGMAFRR
260 270 280 290 300
REYIMGMIKN NPDEEDLKDH GHLFREIYYR YPIIDEILVE FLRGSFKGAE
310 320 330 340 350
KNINIKVGIP AMPMLAKPAK KLDEIKRRLG DGRITGEYKY DGERAQIHKN
360 370 380 390 400
KEGKVRIFSR SAEDSTAKFA DVADIITDNV KGEQYILDSE IVAYDPEKHV
410 420 430 440 450
ILPFQTLMNR PKKGTDTPSA IHVCVCAFDL LSYNGVSMLD EPLEKRRDKL
460 470 480 490 500
HEIVTVVPTK LQLATYKNAS KIEDLGDFFE EAVSNRTEGL MVKTLNGRYE
510 520 530 540 550
CGKRAMSWAK LKKDYISKEV FKGGVAEEIP PDTIDVVVIG ATYGKGKRTS
560 570 580 590 600
VYGAFLVGVY NNVTGKVESL CFVGTGFKED DLKEFYEKLH PLEMEKCPDN
610 620 630 640 650
VDCRPLDQDP VFFKPELVWE IQVADIQTTP TYSACWGELG EKGLTIRFGR
660 670
YYRTRTDKTW EQSTSTEQLL ELYHQQFEK
Length:679
Mass (Da):77,200
Last modified:February 20, 2007 - v1
Checksum:iD0BDA8ADE832366C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113196 Genomic DNA. Translation: EAY20603.1.
RefSeqiXP_001581589.1. XM_001581539.1.

Genome annotation databases

GeneIDi5466150.
KEGGitva:TVAG_162990.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113196 Genomic DNA. Translation: EAY20603.1 .
RefSeqi XP_001581589.1. XM_001581539.1.

3D structure databases

ProteinModelPortali A2DFX6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5722.A2DFX6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5466150.
KEGGi tva:TVAG_162990.

Organism-specific databases

EuPathDBi TrichDB:TVAG_162990.

Phylogenomic databases

eggNOGi COG1793.
InParanoidi A2DFX6.
KOi K10747.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
    Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
    , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
    Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-98 / G3Imported.

Entry informationi

Entry nameiA2DFX6_TRIVA
AccessioniPrimary (citable) accession number: A2DFX6
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3