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Protein

Histone deacetylase

Gene

TVAG_185870

Organism
Trichomonas vaginalis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei97SubstrateUniRule annotation1
Active sitei139Proton acceptorUniRule annotation1
Binding sitei147Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi174Divalent metal cationUniRule annotation1
Metal bindingi176Divalent metal cationUniRule annotation1
Metal bindingi263Divalent metal cationUniRule annotation1
Binding sitei302SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotationImported
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:TVAG_185870Imported
OrganismiTrichomonas vaginalisImported
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
Proteomesi
  • UP000001542 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiTrichDB:TVAG_185870.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi412133.XP_001584265.1.

Structurei

3D structure databases

ProteinModelPortaliA2D8N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 318Hist_deacetylInterPro annotationAdd BLAST293

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
InParanoidiA2D8N0.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A2D8N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEKKKRIV YFYDEDVGNF FYAPNHPMKP HRIRMAHNLI LSYNLFPKLQ
60 70 80 90 100
IYRPKKATVE ELTRFHTPEY IQFLQMATPD NTQNQACLFD KFNVGEDSPV
110 120 130 140 150
FEGLFEFCQS SAGGSISAAR HLNSGHADIA INWAGGLHHA KKGEASGFCY
160 170 180 190 200
VADCVLGILE LLERYDRVMY IDIDIHHGDG VEEAFYTTDR VLTVSFHKFG
210 220 230 240 250
NEFFPGTGHD KDIGLGKGRH YAVNVPLKDG MDDKSYHYIF KPIIKHLIEW
260 270 280 290 300
YRPQAIFLQC GADSLTGDRL GSFNLTIHGH GECVNYVKSF KLPMLVAGGG
310 320 330 340 350
GYTVRNVSRC WTYETAVLLD EEIEDKLPYH DYLGYYGPDY RLDLVPSNMA
360 370 380 390 400
NLNSQESLDH LIESITESIR HLPCAPSVQL CLKDPKKLLE DSDESDNEEF
410 420 430
DDRLASRYVR TRLKINTLYN AEDENPEEDH DVPLN
Length:435
Mass (Da):49,666
Last modified:February 20, 2007 - v1
Checksum:iC4F46DD690FAF44A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS113179 Genomic DNA. Translation: EAY23279.1.
RefSeqiXP_001584265.1. XM_001584215.1.

Genome annotation databases

EnsemblProtistsiEAY23279; EAY23279; TVAG_185870.
GeneIDi5468841.
KEGGitva:TVAG_185870.

Similar proteinsi

Entry informationi

Entry nameiA2D8N0_TRIVA
AccessioniPrimary (citable) accession number: A2D8N0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: August 30, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported