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A2D8N0

- A2D8N0_TRIVA

UniProt

A2D8N0 - A2D8N0_TRIVA

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Protein

Histone deacetylase

Gene

TVAG_185870

Organism
Trichomonas vaginalis
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:TVAG_185870Imported
OrganismiTrichomonas vaginalisImported
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
ProteomesiUP000001542: Unassembled WGS genome

Organism-specific databases

EuPathDBiTrichDB:TVAG_185870.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5722.A2D8N0.

Structurei

3D structure databases

ProteinModelPortaliA2D8N0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0123.
InParanoidiA2D8N0.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A2D8N0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADEKKKRIV YFYDEDVGNF FYAPNHPMKP HRIRMAHNLI LSYNLFPKLQ
60 70 80 90 100
IYRPKKATVE ELTRFHTPEY IQFLQMATPD NTQNQACLFD KFNVGEDSPV
110 120 130 140 150
FEGLFEFCQS SAGGSISAAR HLNSGHADIA INWAGGLHHA KKGEASGFCY
160 170 180 190 200
VADCVLGILE LLERYDRVMY IDIDIHHGDG VEEAFYTTDR VLTVSFHKFG
210 220 230 240 250
NEFFPGTGHD KDIGLGKGRH YAVNVPLKDG MDDKSYHYIF KPIIKHLIEW
260 270 280 290 300
YRPQAIFLQC GADSLTGDRL GSFNLTIHGH GECVNYVKSF KLPMLVAGGG
310 320 330 340 350
GYTVRNVSRC WTYETAVLLD EEIEDKLPYH DYLGYYGPDY RLDLVPSNMA
360 370 380 390 400
NLNSQESLDH LIESITESIR HLPCAPSVQL CLKDPKKLLE DSDESDNEEF
410 420 430
DDRLASRYVR TRLKINTLYN AEDENPEEDH DVPLN
Length:435
Mass (Da):49,666
Last modified:February 20, 2007 - v1
Checksum:iC4F46DD690FAF44A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113179 Genomic DNA. Translation: EAY23279.1.
RefSeqiXP_001584265.1. XM_001584215.1.

Genome annotation databases

GeneIDi5468841.
KEGGitva:TVAG_185870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113179 Genomic DNA. Translation: EAY23279.1 .
RefSeqi XP_001584265.1. XM_001584215.1.

3D structure databases

ProteinModelPortali A2D8N0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5722.A2D8N0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5468841.
KEGGi tva:TVAG_185870.

Organism-specific databases

EuPathDBi TrichDB:TVAG_185870.

Phylogenomic databases

eggNOGi COG0123.
InParanoidi A2D8N0.
KOi K06067.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
    Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
    , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
    Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-98 / G3Imported.

Entry informationi

Entry nameiA2D8N0_TRIVA
AccessioniPrimary (citable) accession number: A2D8N0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3