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A2D8N0

- A2D8N0_TRIVA

UniProt

A2D8N0 - A2D8N0_TRIVA

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Protein
Histone deacetylase
Gene
TVAG_185870
Organism
Trichomonas vaginalis
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotationsImported

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:TVAG_185870Imported
OrganismiTrichomonas vaginalis
Taxonomic identifieri5722 [NCBI]
Taxonomic lineageiEukaryotaParabasaliaTrichomonadidaTrichomonadidaeTrichomonas
ProteomesiUP000001542: Unassembled WGS genome

Organism-specific databases

EuPathDBiTrichDB:TVAG_185870.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5722.A2D8N0.

Structurei

3D structure databases

ProteinModelPortaliA2D8N0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0123.
KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

A2D8N0-1 [UniParc]FASTAAdd to Basket

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MADEKKKRIV YFYDEDVGNF FYAPNHPMKP HRIRMAHNLI LSYNLFPKLQ    50
IYRPKKATVE ELTRFHTPEY IQFLQMATPD NTQNQACLFD KFNVGEDSPV 100
FEGLFEFCQS SAGGSISAAR HLNSGHADIA INWAGGLHHA KKGEASGFCY 150
VADCVLGILE LLERYDRVMY IDIDIHHGDG VEEAFYTTDR VLTVSFHKFG 200
NEFFPGTGHD KDIGLGKGRH YAVNVPLKDG MDDKSYHYIF KPIIKHLIEW 250
YRPQAIFLQC GADSLTGDRL GSFNLTIHGH GECVNYVKSF KLPMLVAGGG 300
GYTVRNVSRC WTYETAVLLD EEIEDKLPYH DYLGYYGPDY RLDLVPSNMA 350
NLNSQESLDH LIESITESIR HLPCAPSVQL CLKDPKKLLE DSDESDNEEF 400
DDRLASRYVR TRLKINTLYN AEDENPEEDH DVPLN 435
Length:435
Mass (Da):49,666
Last modified:February 20, 2007 - v1
Checksum:iC4F46DD690FAF44A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113179 Genomic DNA. Translation: EAY23279.1.
RefSeqiXP_001584265.1. XM_001584215.1.

Genome annotation databases

GeneIDi5468841.
KEGGitva:TVAG_185870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS113179 Genomic DNA. Translation: EAY23279.1 .
RefSeqi XP_001584265.1. XM_001584215.1.

3D structure databases

ProteinModelPortali A2D8N0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5722.A2D8N0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5468841.
KEGGi tva:TVAG_185870.

Organism-specific databases

EuPathDBi TrichDB:TVAG_185870.

Phylogenomic databases

eggNOGi COG0123.
KOi K06067.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis."
    Carlton J.M., Hirt R.P., Silva J.C., Delcher A.L., Schatz M., Zhao Q., Wortman J.R., Bidwell S.L., Alsmark U.C.M., Besteiro S., Sicheritz-Ponten T., Noel C.J., Dacks J.B., Foster P.G., Simillion C., Van de Peer Y., Miranda-Saavedra D., Barton G.J.
    , Westrop G.D., Mueller S., Dessi D., Fiori P.L., Ren Q., Paulsen I., Zhang H., Bastida-Corcuera F.D., Simoes-Barbosa A., Brown M.T., Hayes R.D., Mukherjee M., Okumura C.Y., Schneider R., Smith A.J., Vanacova S., Villalvazo M., Haas B.J., Pertea M., Feldblyum T.V., Utterback T.R., Shu C.L., Osoegawa K., de Jong P.J., Hrdy I., Horvathova L., Zubacova Z., Dolezal P., Malik S.B., Logsdon J.M. Jr., Henze K., Gupta A., Wang C.C., Dunne R.L., Upcroft J.A., Upcroft P., White O., Salzberg S.L., Tang P., Chiu C.-H., Lee Y.-S., Embley T.M., Coombs G.H., Mottram J.C., Tachezy J., Fraser-Liggett C.M., Johnson P.J.
    Science 315:207-212(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-98 / G3.

Entry informationi

Entry nameiA2D8N0_TRIVA
AccessioniPrimary (citable) accession number: A2D8N0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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