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Protein

Osteocalcin

Gene

BGLAP

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi68Calcium 3By similarity1
Metal bindingi72Calcium 2By similarity1
Metal bindingi75Calcium 1By similarity1
Metal bindingi75Calcium 2By similarity1
Metal bindingi81Calcium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23CuratedAdd BLAST23
PropeptideiPRO_000028541224 – 51By similarityAdd BLAST28
ChainiPRO_000028541352 – 100OsteocalcinAdd BLAST49

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei604-hydroxyprolineBy similarity1
Modified residuei684-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Modified residuei724-carboxyglutamatePROSITE-ProRule annotationBy similarity1
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation
Modified residuei754-carboxyglutamatePROSITE-ProRule annotationBy similarity1

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Gene expression databases

BgeeiENSMMUG00000000084.
ExpressionAtlasiA2D670. differential.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000113.

Structurei

3D structure databases

ProteinModelPortaliA2D670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 98GlaPROSITE-ProRule annotationAdd BLAST47

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00390000006469.
HOGENOMiHOG000115820.
InParanoidiA2D670.
OMAiNCDELAD.
OrthoDBiEOG091G13UG.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2D670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALTLLALL ALATLCITGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR
60 70 80 90 100
RYLYQWLGAP APYPDPLEPK REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):10,967
Last modified:February 20, 2007 - v1
Checksum:i1A19C5A6FCE2D255
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976876 Genomic DNA. Translation: ABM55163.1.
RefSeqiNP_001074237.1. NM_001080768.1.
UniGeneiMmu.16486.

Genome annotation databases

EnsembliENSMMUT00000000124; ENSMMUP00000000113; ENSMMUG00000000083.
GeneIDi718296.
KEGGimcc:718296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976876 Genomic DNA. Translation: ABM55163.1.
RefSeqiNP_001074237.1. NM_001080768.1.
UniGeneiMmu.16486.

3D structure databases

ProteinModelPortaliA2D670.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000000124; ENSMMUP00000000113; ENSMMUG00000000083.
GeneIDi718296.
KEGGimcc:718296.

Organism-specific databases

CTDi632.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
GeneTreeiENSGT00390000006469.
HOGENOMiHOG000115820.
InParanoidiA2D670.
OMAiNCDELAD.
OrthoDBiEOG091G13UG.
TreeFamiTF330920.

Gene expression databases

BgeeiENSMMUG00000000084.
ExpressionAtlasiA2D670. differential.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTCN_MACMU
AccessioniPrimary (citable) accession number: A2D670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.