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Protein

Osteocalcin

Gene

BGLAP

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi68 – 681Calcium 3By similarity
Metal bindingi72 – 721Calcium 2By similarity
Metal bindingi75 – 751Calcium 1By similarity
Metal bindingi75 – 751Calcium 2By similarity
Metal bindingi81 – 811Calcium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Biomineralization

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Osteocalcin
Alternative name(s):
Bone Gla protein
Short name:
BGP
Gamma-carboxyglutamic acid-containing protein
Gene namesi
Name:BGLAP
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323CuratedAdd
BLAST
Propeptidei24 – 5128By similarityPRO_0000285412Add
BLAST
Chaini52 – 10049OsteocalcinPRO_0000285413Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 6014-hydroxyprolineBy similarity
Modified residuei68 – 6814-carboxyglutamatePROSITE-ProRule annotationBy similarity
Modified residuei72 – 7214-carboxyglutamatePROSITE-ProRule annotationBy similarity
Disulfide bondi74 ↔ 80PROSITE-ProRule annotation
Modified residuei75 – 7514-carboxyglutamatePROSITE-ProRule annotationBy similarity

Post-translational modificationi

Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Gamma-carboxyglutamic acid, Hydroxylation

Expressioni

Gene expression databases

BgeeiENSMMUG00000000084.
ExpressionAtlasiA2D670. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000113.

Structurei

3D structure databases

ProteinModelPortaliA2D670.
SMRiA2D670. Positions 69-100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini52 – 9847GlaPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 Gla (gamma-carboxy-glutamate) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
HOGENOMiHOG000115820.
InParanoidiA2D670.
OMAiNCDELAD.
OrthoDBiEOG091G13UG.
TreeFamiTF330920.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A2D670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRALTLLALL ALATLCITGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR
60 70 80 90 100
RYLYQWLGAP APYPDPLEPK REVCELNPDC DELADHIGFQ EAYRRFYGPV
Length:100
Mass (Da):10,967
Last modified:February 20, 2007 - v1
Checksum:i1A19C5A6FCE2D255
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976876 Genomic DNA. Translation: ABM55163.1.
RefSeqiNP_001074237.1. NM_001080768.1.
UniGeneiMmu.16486.

Genome annotation databases

EnsembliENSMMUT00000000124; ENSMMUP00000000113; ENSMMUG00000000084.
GeneIDi718296.
KEGGimcc:718296.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976876 Genomic DNA. Translation: ABM55163.1.
RefSeqiNP_001074237.1. NM_001080768.1.
UniGeneiMmu.16486.

3D structure databases

ProteinModelPortaliA2D670.
SMRiA2D670. Positions 69-100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000000113.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMMUT00000000124; ENSMMUP00000000113; ENSMMUG00000000084.
GeneIDi718296.
KEGGimcc:718296.

Organism-specific databases

CTDi632.

Phylogenomic databases

eggNOGiENOG410J11Z. Eukaryota.
ENOG410ZS6W. LUCA.
HOGENOMiHOG000115820.
InParanoidiA2D670.
OMAiNCDELAD.
OrthoDBiEOG091G13UG.
TreeFamiTF330920.

Gene expression databases

BgeeiENSMMUG00000000084.
ExpressionAtlasiA2D670. baseline.

Family and domain databases

InterProiIPR000294. GLA_domain.
IPR002384. Osteocalcin/MGP.
[Graphical view]
PRINTSiPR00002. GLABONE.
SMARTiSM00069. GLA. 1 hit.
[Graphical view]
SUPFAMiSSF57630. SSF57630. 1 hit.
PROSITEiPS00011. GLA_1. 1 hit.
PS50998. GLA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOSTCN_MACMU
AccessioniPrimary (citable) accession number: A2D670
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.