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Protein

Homeobox protein Hox-B1

Gene

HOXB1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi206 – 265HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B1
Gene namesi
Name:HOXB1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000006718 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002854231 – 304Homeobox protein Hox-B1Add BLAST304

Expressioni

Gene expression databases

BgeeiENSMMUG00000022212

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000029241

Structurei

3D structure databases

ProteinModelPortaliA2D649
SMRiA2D649
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi182 – 187Antp-type hexapeptide6

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144005
HOGENOMiHOG000247020
HOVERGENiHBG006089
InParanoidiA2D649
KOiK09301
OMAiYAICNRG
OrthoDBiEOG091G0LR2
TreeFamiTF317730

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

A2D649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDYNRMNSFL EYPLCNRGPS AYSAHSAHSA PTSFPPSSTQ AVDSYASEGR
60 70 80 90 100
YGGGLSSPAF QQNSGYPAQQ PPSALGVPFP SSAPSGYAPA ACSPSYGPSQ
110 120 130 140 150
YYPLGQSEGD GGYFHPTSYG AQLGGLSDGY GAGGAGPGPY PPQHPPYGNE
160 170 180 190 200
QTASFAPAYA DLLSEDKEAP CPSEPNTPTA RTFDWMKVKR NPPKTGKVSE
210 220 230 240 250
PGLGSPSGLR TNFTTRQLTE LEKEFHFNKY LSRARRVEIA ATLELNETQV
260 270 280 290 300
KIWFQNRRMK QKKREREGGR VPPAPPGCPK EAAGDASDQS TCTSPEASPS

SVTS
Length:304
Mass (Da):32,387
Last modified:February 20, 2007 - v1
Checksum:i4627A59FA06267DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ976864 Genomic DNA Translation: ABM55142.1
RefSeqiNP_001074229.1, NM_001080760.1
UniGeneiMmu.17234

Genome annotation databases

EnsembliENSMMUT00000031244; ENSMMUP00000029241; ENSMMUG00000022212
GeneIDi696111
KEGGimcc:696111

Similar proteinsi

Entry informationi

Entry nameiHXB1_MACMU
AccessioniPrimary (citable) accession number: A2D649
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome