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A2D649

- HXB1_MACMU

UniProt

A2D649 - HXB1_MACMU

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Protein

Homeobox protein Hox-B1

Gene

HOXB1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi206 – 26560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: Ensembl
  2. anterior/posterior pattern specification Source: Ensembl
  3. embryonic skeletal system morphogenesis Source: Ensembl
  4. facial nerve structural organization Source: Ensembl
  5. facial nucleus development Source: Ensembl
  6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  7. rhombomere 4 development Source: Ensembl
  8. rhombomere 5 development Source: Ensembl
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B1
Gene namesi
Name:HOXB1
OrganismiMacaca mulatta (Rhesus macaque)
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
ProteomesiUP000006718: Chromosome 16

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 304304Homeobox protein Hox-B1PRO_0000285423Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9544.ENSMMUP00000029241.

Structurei

3D structure databases

ProteinModelPortaliA2D649.
SMRiA2D649. Positions 180-267.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi182 – 1876Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family. Labial subfamily.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG236971.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000247020.
HOVERGENiHBG006089.
InParanoidiA2D649.
KOiK09301.
OMAiYAICNRG.
OrthoDBiEOG7PK91P.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2D649-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDYNRMNSFL EYPLCNRGPS AYSAHSAHSA PTSFPPSSTQ AVDSYASEGR
60 70 80 90 100
YGGGLSSPAF QQNSGYPAQQ PPSALGVPFP SSAPSGYAPA ACSPSYGPSQ
110 120 130 140 150
YYPLGQSEGD GGYFHPTSYG AQLGGLSDGY GAGGAGPGPY PPQHPPYGNE
160 170 180 190 200
QTASFAPAYA DLLSEDKEAP CPSEPNTPTA RTFDWMKVKR NPPKTGKVSE
210 220 230 240 250
PGLGSPSGLR TNFTTRQLTE LEKEFHFNKY LSRARRVEIA ATLELNETQV
260 270 280 290 300
KIWFQNRRMK QKKREREGGR VPPAPPGCPK EAAGDASDQS TCTSPEASPS

SVTS
Length:304
Mass (Da):32,387
Last modified:February 20, 2007 - v1
Checksum:i4627A59FA06267DB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ976864 Genomic DNA. Translation: ABM55142.1.
RefSeqiNP_001074229.1. NM_001080760.1.
UniGeneiMmu.17234.

Genome annotation databases

EnsembliENSMMUT00000031244; ENSMMUP00000029241; ENSMMUG00000022212.
GeneIDi696111.
KEGGimcc:696111.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ976864 Genomic DNA. Translation: ABM55142.1 .
RefSeqi NP_001074229.1. NM_001080760.1.
UniGenei Mmu.17234.

3D structure databases

ProteinModelPortali A2D649.
SMRi A2D649. Positions 180-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9544.ENSMMUP00000029241.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMMUT00000031244 ; ENSMMUP00000029241 ; ENSMMUG00000022212 .
GeneIDi 696111.
KEGGi mcc:696111.

Organism-specific databases

CTDi 3211.

Phylogenomic databases

eggNOGi NOG236971.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000247020.
HOVERGENi HBG006089.
InParanoidi A2D649.
KOi K09301.
OMAi YAICNRG.
OrthoDBi EOG7PK91P.
TreeFami TF317730.

Miscellaneous databases

NextBioi 19985606.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Positive selection in transcription factor genes on the human lineage."
    Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
    Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiHXB1_MACMU
AccessioniPrimary (citable) accession number: A2D649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3