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A2D649 (HXB1_MACMU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B1
Gene names
Name:HOXB1
OrganismMacaca mulatta (Rhesus macaque) [Reference proteome]
Taxonomic identifier9544 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length304 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Antp homeobox family. Labial subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 304304Homeobox protein Hox-B1
PRO_0000285423

Regions

DNA binding206 – 26560Homeobox
Motif182 – 1876Antp-type hexapeptide

Sequences

Sequence LengthMass (Da)Tools
A2D649 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 4627A59FA06267DB

FASTA30432,387
        10         20         30         40         50         60 
MDYNRMNSFL EYPLCNRGPS AYSAHSAHSA PTSFPPSSTQ AVDSYASEGR YGGGLSSPAF 

        70         80         90        100        110        120 
QQNSGYPAQQ PPSALGVPFP SSAPSGYAPA ACSPSYGPSQ YYPLGQSEGD GGYFHPTSYG 

       130        140        150        160        170        180 
AQLGGLSDGY GAGGAGPGPY PPQHPPYGNE QTASFAPAYA DLLSEDKEAP CPSEPNTPTA 

       190        200        210        220        230        240 
RTFDWMKVKR NPPKTGKVSE PGLGSPSGLR TNFTTRQLTE LEKEFHFNKY LSRARRVEIA 

       250        260        270        280        290        300 
ATLELNETQV KIWFQNRRMK QKKREREGGR VPPAPPGCPK EAAGDASDQS TCTSPEASPS 


SVTS 

« Hide

References

[1]"Positive selection in transcription factor genes on the human lineage."
Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ976864 Genomic DNA. Translation: ABM55142.1.
RefSeqNP_001074229.1. NM_001080760.1.
UniGeneMmu.17234.

3D structure databases

ProteinModelPortalA2D649.
SMRA2D649. Positions 180-267.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9544.ENSMMUP00000029241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMMUT00000031244; ENSMMUP00000029241; ENSMMUG00000022212.
GeneID696111.
KEGGmcc:696111.

Organism-specific databases

CTD3211.

Phylogenomic databases

eggNOGNOG236971.
GeneTreeENSGT00750000117389.
HOGENOMHOG000247020.
HOVERGENHBG006089.
KOK09301.
OMAYAGETRY.
OrthoDBEOG7PK91P.
TreeFamTF317730.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio19985606.

Entry information

Entry nameHXB1_MACMU
AccessionPrimary (citable) accession number: A2D649
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: February 20, 2007
Last modified: April 16, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries