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A2D649

- HXB1_MACMU

UniProt

A2D649 - HXB1_MACMU

Protein

Homeobox protein Hox-B1

Gene

HOXB1

Organism
Macaca mulatta (Rhesus macaque)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Acts on the anterior body structures By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi206 – 26560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: Ensembl
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anatomical structure formation involved in morphogenesis Source: Ensembl
    2. anterior/posterior pattern specification Source: Ensembl
    3. embryonic skeletal system morphogenesis Source: Ensembl
    4. facial nerve structural organization Source: Ensembl
    5. facial nucleus development Source: Ensembl
    6. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    7. rhombomere 4 development Source: Ensembl
    8. rhombomere 5 development Source: Ensembl
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B1
    Gene namesi
    Name:HOXB1
    OrganismiMacaca mulatta (Rhesus macaque)
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
    ProteomesiUP000006718: Chromosome 16

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 304304Homeobox protein Hox-B1PRO_0000285423Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi9544.ENSMMUP00000029241.

    Structurei

    3D structure databases

    ProteinModelPortaliA2D649.
    SMRiA2D649. Positions 180-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi182 – 1876Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family. Labial subfamily.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG236971.
    GeneTreeiENSGT00750000117389.
    HOGENOMiHOG000247020.
    HOVERGENiHBG006089.
    KOiK09301.
    OMAiYAICNRG.
    OrthoDBiEOG7PK91P.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2D649-1 [UniParc]FASTAAdd to Basket

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    MDYNRMNSFL EYPLCNRGPS AYSAHSAHSA PTSFPPSSTQ AVDSYASEGR    50
    YGGGLSSPAF QQNSGYPAQQ PPSALGVPFP SSAPSGYAPA ACSPSYGPSQ 100
    YYPLGQSEGD GGYFHPTSYG AQLGGLSDGY GAGGAGPGPY PPQHPPYGNE 150
    QTASFAPAYA DLLSEDKEAP CPSEPNTPTA RTFDWMKVKR NPPKTGKVSE 200
    PGLGSPSGLR TNFTTRQLTE LEKEFHFNKY LSRARRVEIA ATLELNETQV 250
    KIWFQNRRMK QKKREREGGR VPPAPPGCPK EAAGDASDQS TCTSPEASPS 300
    SVTS 304
    Length:304
    Mass (Da):32,387
    Last modified:February 20, 2007 - v1
    Checksum:i4627A59FA06267DB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976864 Genomic DNA. Translation: ABM55142.1.
    RefSeqiNP_001074229.1. NM_001080760.1.
    UniGeneiMmu.17234.

    Genome annotation databases

    EnsembliENSMMUT00000031244; ENSMMUP00000029241; ENSMMUG00000022212.
    GeneIDi696111.
    KEGGimcc:696111.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976864 Genomic DNA. Translation: ABM55142.1 .
    RefSeqi NP_001074229.1. NM_001080760.1.
    UniGenei Mmu.17234.

    3D structure databases

    ProteinModelPortali A2D649.
    SMRi A2D649. Positions 180-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9544.ENSMMUP00000029241.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMMUT00000031244 ; ENSMMUP00000029241 ; ENSMMUG00000022212 .
    GeneIDi 696111.
    KEGGi mcc:696111.

    Organism-specific databases

    CTDi 3211.

    Phylogenomic databases

    eggNOGi NOG236971.
    GeneTreei ENSGT00750000117389.
    HOGENOMi HOG000247020.
    HOVERGENi HBG006089.
    KOi K09301.
    OMAi YAICNRG.
    OrthoDBi EOG7PK91P.
    TreeFami TF317730.

    Miscellaneous databases

    NextBioi 19985606.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection in transcription factor genes on the human lineage."
      Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHXB1_MACMU
    AccessioniPrimary (citable) accession number: A2D649
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3