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A2D5Y4

- HXA5_LEMCA

UniProt

A2D5Y4 - HXA5_LEMCA

Protein

Homeobox protein Hox-A5

Gene

HOXA5

Organism
Lemur catta (Ring-tailed lemur)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3' By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi195 – 25460HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-A5
    Gene namesi
    Name:HOXA5
    OrganismiLemur catta (Ring-tailed lemur)
    Taxonomic identifieri9447 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesStrepsirrhiniLemuriformesLemuridaeLemur

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 270270Homeobox protein Hox-A5PRO_0000285419Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliA2D5Y4.
    SMRiA2D5Y4. Positions 174-255.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi176 – 1816Antp-type hexapeptide

    Sequence similaritiesi

    Belongs to the Antp homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    HOVERGENiHBG016849.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2D5Y4-1 [UniParc]FASTAAdd to Basket

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    MSSYFVNSFC GRYPNGPDYQ LHNYGDHSSV SEQFRDSASM HSGRYGYGYN    50
    GMDLSVGRSG SGHFGSGERA RSYAAGATTA PAEPRYSQPA TSTHSPPPDP 100
    LPCSAVAPSP GSDSHHGGKN SLGNSSGASA NAGSTHISSR EGVGTASGAE 150
    EDAPASSEQA SAQSEPSPAP PAQPQIYPWM RKLHISHDNI GGPEGKRART 200
    AYTRYQTLEL EKEFHFNRYL TRRRRIEIAH ALCLSERQIK IWFQNRRMKW 250
    KKDNKLKSMS MAAAGGAFRP 270
    Length:270
    Mass (Da):29,297
    Last modified:February 20, 2007 - v1
    Checksum:iEB83C065FA0D3B07
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976822 Genomic DNA. Translation: ABM68948.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ976822 Genomic DNA. Translation: ABM68948.1 .

    3D structure databases

    ProteinModelPortali A2D5Y4.
    SMRi A2D5Y4. Positions 174-255.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG016849.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017995. Homeobox_antennapedia.
    IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00025. ANTENNAPEDIA.
    PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Positive selection in transcription factor genes on the human lineage."
      Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.
      Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiHXA5_LEMCA
    AccessioniPrimary (citable) accession number: A2D5Y4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3