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Protein

Dystrotelin

Gene

DYTN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 26948ZZ-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dystrotelin
Gene namesi
Name:DYTN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:23279. DYTN.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162384136.

Polymorphism and mutation databases

BioMutaiDYTN.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578DystrotelinPRO_0000298934Add
BLAST

Proteomic databases

EPDiA2CJ06.
PaxDbiA2CJ06.
PRIDEiA2CJ06.

PTM databases

iPTMnetiA2CJ06.
PhosphoSiteiA2CJ06.

Expressioni

Gene expression databases

CleanExiHS_DYTN.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000396593.

Structurei

3D structure databases

ProteinModelPortaliA2CJ06.
SMRiA2CJ06. Positions 9-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili322 – 35130Sequence analysisAdd
BLAST
Coiled coili503 – 53735Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi110 – 1134Poly-Ala
Compositional biasi389 – 3924Poly-Ser
Compositional biasi523 – 5264Poly-Glu

Sequence similaritiesi

Contains 1 ZZ-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri222 – 26948ZZ-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IME9. Eukaryota.
ENOG410Y9MN. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000112301.
HOVERGENiHBG095875.
InParanoidiA2CJ06.
OMAiQKSHPVI.
OrthoDBiEOG091G03GT.
PhylomeDBiA2CJ06.
TreeFamiTF326090.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2CJ06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPDKQDALN SIENSIYRTA FKLQSVQTLC QLDLIDSSLI QQVLLRPSFW
60 70 80 90 100
EARKHSLSVQ QLSQALQELF QKAREENPGQ VHPRAPELTL SLLTTMYNSK
110 120 130 140 150
GTGFLQLMPA AAALITLSGD SPLSKYRALF QLYAENSRGG YDSGPRMTRR
160 170 180 190 200
VLRKLLTDLQ QIPTFVGESR ALCPVESATR SCFQGVLSPA IKEEKFLSWV
210 220 230 240 250
QSEPPILLWL PTCHRLSAAE RVTHPARCTL CRTFPITGLR YRCLKCLNFD
260 270 280 290 300
ICQMCFLSGL HSKSHQKSHP VIEHCIQMSA MQNTKLLFRT LRNNLLQGRC
310 320 330 340 350
RKKEAARRQQ LLDQVNPKGV PHHAQARLLK KQLNQYKDKL QAIYTSQEER
360 370 380 390 400
ICRFETRIHK LKTNQDSLWT KLQQIRRDLQ ARLQPPGPSS SSFQNVGNKV
410 420 430 440 450
DHSSTEKVPK GGDYLQIKNA TEDASTGEPL PKLDEVDRSH RSHTNAEHAL
460 470 480 490 500
RNPESPETTL HSTRAQSQTQ KMPQKVISAL PSYQEGLKQD IPKMVPAEMS
510 520 530 540 550
SPALAAVEKK EAGNIKERKD ELEEEELQEL LSKLMDAFNL ETPSGPESSV
560 570
NMDLYSGAQR VCRAFSALVD QIALPNLK
Length:578
Mass (Da):65,320
Last modified:February 20, 2007 - v1
Checksum:iEC7BC442A8F38644
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti241 – 2411Y → C.
Corresponds to variant rs16838593 [ dbSNP | Ensembl ].
VAR_050960
Natural varianti474 – 4741Q → K.
Corresponds to variant rs2115591 [ dbSNP | Ensembl ].
VAR_050961

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ516347 mRNA. Translation: ABF55377.1.
CCDSiCCDS46502.1.
RefSeqiNP_001087199.1. NM_001093730.1.
UniGeneiHs.640667.

Genome annotation databases

EnsembliENST00000452335; ENSP00000396593; ENSG00000232125.
GeneIDi391475.
KEGGihsa:391475.
UCSCiuc002vbr.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ516347 mRNA. Translation: ABF55377.1.
CCDSiCCDS46502.1.
RefSeqiNP_001087199.1. NM_001093730.1.
UniGeneiHs.640667.

3D structure databases

ProteinModelPortaliA2CJ06.
SMRiA2CJ06. Positions 9-274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000396593.

PTM databases

iPTMnetiA2CJ06.
PhosphoSiteiA2CJ06.

Polymorphism and mutation databases

BioMutaiDYTN.

Proteomic databases

EPDiA2CJ06.
PaxDbiA2CJ06.
PRIDEiA2CJ06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000452335; ENSP00000396593; ENSG00000232125.
GeneIDi391475.
KEGGihsa:391475.
UCSCiuc002vbr.1. human.

Organism-specific databases

CTDi391475.
GeneCardsiDYTN.
HGNCiHGNC:23279. DYTN.
neXtProtiNX_A2CJ06.
PharmGKBiPA162384136.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IME9. Eukaryota.
ENOG410Y9MN. LUCA.
GeneTreeiENSGT00760000119237.
HOGENOMiHOG000112301.
HOVERGENiHBG095875.
InParanoidiA2CJ06.
OMAiQKSHPVI.
OrthoDBiEOG091G03GT.
PhylomeDBiA2CJ06.
TreeFamiTF326090.

Miscellaneous databases

GenomeRNAii391475.
PROiA2CJ06.

Gene expression databases

CleanExiHS_DYTN.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR015153. EF-hand_dom_typ1.
IPR015154. EF-hand_dom_typ2.
IPR000433. Znf_ZZ.
[Graphical view]
PfamiPF09068. EF-hand_2. 1 hit.
PF09069. EF-hand_3. 1 hit.
PF00569. ZZ. 1 hit.
[Graphical view]
SMARTiSM00291. ZnF_ZZ. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS01357. ZF_ZZ_1. 1 hit.
PS50135. ZF_ZZ_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDYTN_HUMAN
AccessioniPrimary (citable) accession number: A2CJ06
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: February 20, 2007
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.