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A2CI41 (FTSI_CHLAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peptidoglycan synthase ftsI homolog

EC=2.4.1.129
Alternative name(s):
Peptidoglycan glycosyltransferase
Gene names
Name:ftsI
Encoded onPlastid; Chloroplast
OrganismChlorokybus atmophyticus (Soil alga)
Taxonomic identifier3144 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaChlorokybophyceaeChlorokybalesChlorokybaceaeChlorokybus

Protein attributes

Sequence length679 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates Potential.

Catalytic activity

(GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n)-diphosphoundecaprenol + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = (GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala))(n+1)-diphosphoundecaprenol + undecaprenyl diphosphate.

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis.

Subcellular location

Plastidchloroplast membrane; Single-pass membrane protein Potential.

Miscellaneous

The presence of this gene in the chloroplast genome suggests there may be an unsuspected vestigal peptidoglycan layer in this organism's chloroplasts.

Sequence similarities

Belongs to the transpeptidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 679679Peptidoglycan synthase ftsI homolog
PRO_0000314459

Regions

Transmembrane13 – 3321Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A2CI41 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: 55BEB81500C9F33E

FASTA67975,878
        10         20         30         40         50         60 
MKPYEPKSWV TRVFLVWWLT ALSCFFISGR LIYLQLLKGK WLKEKALKQQ TVTLKTFQPR 

        70         80         90        100        110        120 
RNICDRNGIP LAIDTLAYDV FAHPLYFSIS IEEVANKLSP ILCIDSLSIQ KLLKPTSTGI 

       130        140        150        160        170        180 
CLASQLPENT GKLIASLRLD GIDLIKHPKR YYPYKEIVGN VIGYVDTSHQ GQAGIELSCQ 

       190        200        210        220        230        240 
ESLQLNSPTL TSSIDGRGVL ISHQIPKELF IQDNLSLQLT LDLELQKIAY KALKQGLENC 

       250        260        270        280        290        300 
KGKRGTVLIL DPKTGGILTL VALPSYDPNI YYDFPIERFK PWPVTDLYEP GSTFKPLNIA 

       310        320        330        340        350        360 
IALETKAISP EDSFYDEGCI RVGDSIITNN DYNSYKPLPC LPNTYNKIVK LLANSSNVGM 

       370        380        390        400        410        420 
VHILERIAPE IYHSWLSKLD LGHAASPLET DLPWASESSL KDINEFVCYE IEPAAASFGQ 

       430        440        450        460        470        480 
GLAMTPIKLA QLYASLANGG ILVKPYLVTG LANAAEDTQK AKGIDLPSYN IRKKNLGNHL 

       490        500        510        520        530        540 
SWHKAEPSYL FLKRSGIRVT DLLRHIKAEG RFALPFRKNL LQLFTQDAHR TTELQLEPKA 

       550        560        570        580        590        600 
HQPQLLRPTR HAVYATNQSK RVFSHETTKL LLDMLEDVIW NGTGSSCFVE GYRIGGKTGT 

       610        620        630        640        650        660 
SQKHTQEGGY SKTKIITSFA AIFPTEDPQY VILTVIDEPN IPLSFGSNTA APIVKSIIES 

       670 
LIDIKKMKPT IPIIKVKKD 

« Hide

References

[1]"A clade uniting the green algae Mesostigma viride and Chlorokybus atmophyticus represents the deepest branch of the Streptophyta in chloroplast genome-based phylogenies."
Lemieux C., Otis C., Turmel M.
BMC Biol. 5:2-2(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SAG 48.80.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ422812 Genomic DNA. Translation: ABM87954.1.
RefSeqYP_001019071.1. NC_008822.1.

3D structure databases

ProteinModelPortalA2CI41.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID4783320.

Phylogenomic databases

ProtClustDBCLSC858421.

Enzyme and pathway databases

UniPathwayUPA00219.

Family and domain databases

Gene3D3.40.710.10. 2 hits.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 2 hits.
[Graphical view]
SUPFAMSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 2 hits.
ProtoNetSearch...

Entry information

Entry nameFTSI_CHLAT
AccessionPrimary (citable) accession number: A2CI41
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways