Reviewed, UniProtKB/Swiss-Prot A2CI35 (DUSTY_STRPU)

Names and origin

Protein names

Recommended name:
    Dual serine/threonine and tyrosine protein kinase
    EC=2.7.12.1
Alternative name(s):
    Dusty protein kinase
      Short name=Dusty PK
    Receptor-interacting serine/threonine-protein kinase 5

Gene names

Name:	DSTYK
Synonyms:	RIPK5

Organism

Strongylocentrotus purpuratus (Purple sea urchin)

Taxonomic identifier

7668 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Echinoida › Strongylocentrotidae › Strongylocentrotus

Protein attributes

Sequence length	953 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	May induce both caspase-dependent apoptosis and caspase-independent cell death By similarity. UniProtKB Q6XUX3
Catalytic activity	ATP + a protein = ADP + a phosphoprotein. UniProtKB P16879
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase Tyrosine-protein kinase
Gene Ontology (GO)
Biological process	protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 953	953	Dual serine/threonine and tyrosine protein kinase		PRO_0000374059
Regions
	Domain	665 – 926	262	Protein kinase
	Nucleotide binding	671 – 679	9	ATP By similarity
	Compositional bias	936 – 941	6	Poly-Gly
Sites
	Active site	791	1	Proton acceptor By similarity
	Binding site	694	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	A2CI35-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: 1769C6082B6BD2EA	FASTA	953	108,380
	10 20 30 40 50 60 MSSRRLGSSR ARGRDLAHEV KHFGGLTKHL KKIIFDSNNC LTELKTSDHF EEEVISTLVL 70 80 90 100 110 120 PPVADEIVGK VTKNPPALVI FGQTYTSKAT LVNKIFREDL FQIVDDSDNN KTWRAVHLKY 130 140 150 160 170 180 GSQRNTRLTL TNSFELLNEE PGSPVMRNSW TGIPRVEMLV KEEHQKDACM LSATTEATLN 190 200 210 220 230 240 HPLLQCKLQI LVTPHNCPGI SISQAYNVCT HNVLPVLLYC FDKDQLSEEN LRDLQELQNC 250 260 270 280 290 300 AGTLPILFVD CREPSEPLVA HRERRLVEDA HEDFDDDSAY DTDERIEGER ERHNGLDARL 310 320 330 340 350 360 RRRCRPTPND RPSVIDQLSR AGFISSPEEN GRMRGVLDVF TIVNQVEDLH NSAAIVQFIR 370 380 390 400 410 420 RSLQYYLIRC CTAMHDLHQH CMNLFITTAF DMQRDILVTP KRIEYARQRE NELFDSLKDL 430 440 450 460 470 480 TNQKQEQLRS LIQSTVADMT EDLLEQAGNY RFTDLEVSQE GKIQSQKDIK RCTEQIQDLV 490 500 510 520 530 540 LARLNACVVE KLIGSVELLR ESFLGTLQRC LASLEKIDGD LETSTTVALR QILNAAYQVE 550 560 570 580 590 600 VSVRTSSSVV RIIWERMKEF FQSIKPFKTP TRVDTEWKRK VAQTMINNLD ESKLAKSICS 610 620 630 640 650 660 QFRSRLNNSH ESFSTSLRQL EQKHSGRLEK TEEQRMKVRK VYAPRLARLA LESTSLRDMV 670 680 690 700 710 720 LYGMPKLERE IGRGQYGVVY SCRSWGGVTH CAVKSVVPPD DKHWNDLAME FHYTRSIAEH 730 740 750 760 770 780 DRIVAVIGSV IDHGYGGMGC SPAVLLLMER MQRDLHTAIK ANMELPERLH VALDVAEGVR 790 800 810 820 830 840 YLHSLGLVHR DIKLKNVLLD KHDRGKITDL GFCKPEAMMS GSIVGTPIHM APELFSGKYD 850 860 870 880 890 900 NSVDTYAFGI LLWYVCAGHV KLPQAFEQCA NKDHLWTSVK KGVRPERLRP QFDDASWNLM 910 920 930 940 950 KSSWAGEPSE RPLLGEVQSK LQDIYTKALA KREAEGGGGG GAKEQQNLKS DTL

References

[1]

"Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain." Peng J., Dong W., Chen Y., Mo R., Cheng J.-F., Hui C.-C., Mohandas N., Huang C.-H. Biochim. Biophys. Acta 1759:562-572(2006) [PubMed: 17123648] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ419946 mRNA. Translation: ABD77594.1.
RefSeq	NP_001091920.1.
UniGene	Spu.20766
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	581730.
KEGG	spu:581730.
Family and domain databases
InterPro	IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DUSTY_STRPU

Accession

Primary (citable) accession number: A2CI35

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	February 20, 2007
Last modified:	October 13, 2009
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)