Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

A2CG63

- ARI4B_MOUSE

UniProt

A2CG63 - ARI4B_MOUSE

Protein

AT-rich interactive domain-containing protein 4B

Gene

Arid4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. establishment of Sertoli cell barrier Source: MGI
    2. histone H3-K9 trimethylation Source: MGI
    3. histone H4-K20 trimethylation Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. regulation of gene expression by genetic imprinting Source: MGI
    6. spermatogenesis Source: MGI
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AT-rich interactive domain-containing protein 4B
    Short name:
    ARID domain-containing protein 4B
    Alternative name(s):
    180 kDa Sin3-associated polypeptide
    Short name:
    Sin3-associated polypeptide p180
    Histone deacetylase complex subunit SAP180
    Gene namesi
    Name:Arid4b
    Synonyms:Sap180
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:2137512. Arid4b.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13141314AT-rich interactive domain-containing protein 4BPRO_0000282864Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei276 – 2761PhosphoserineBy similarity
    Modified residuei666 – 6661PhosphoserineBy similarity
    Modified residuei675 – 6751PhosphoserineBy similarity
    Modified residuei717 – 7171PhosphoserineBy similarity
    Modified residuei778 – 7781PhosphoserineBy similarity
    Modified residuei790 – 7901PhosphoserineBy similarity
    Modified residuei793 – 7931PhosphothreonineBy similarity
    Modified residuei1016 – 10161PhosphoserineBy similarity
    Modified residuei1028 – 10281PhosphothreonineBy similarity
    Modified residuei1152 – 11521PhosphothreonineBy similarity
    Modified residuei1154 – 11541PhosphoserineBy similarity
    Modified residuei1155 – 11551PhosphoserineBy similarity
    Modified residuei1157 – 11571PhosphoserineBy similarity
    Modified residuei1161 – 11611PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiA2CG63.
    PRIDEiA2CG63.

    PTM databases

    PhosphoSiteiA2CG63.

    Expressioni

    Gene expression databases

    ArrayExpressiA2CG63.
    BgeeiA2CG63.
    CleanExiMM_ARID4B.
    GenevestigatoriA2CG63.

    Interactioni

    Subunit structurei

    Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Stra8P702784EBI-6394082,EBI-6394115

    Protein-protein interaction databases

    BioGridi220492. 2 interactions.
    IntActiA2CG63. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliA2CG63.
    SMRiA2CG63. Positions 5-121, 170-271, 301-402, 564-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini306 – 39893ARIDPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1227 – 127246Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi154 – 1596Poly-Ser
    Compositional biasi268 – 567300Glu-richAdd
    BLAST
    Compositional biasi1097 – 11037Poly-Ser
    Compositional biasi1273 – 130533Ser-richAdd
    BLAST

    Domaini

    The C-terminus mediates interaction with mSin3A corepressor complex.By similarity
    The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.By similarity
    The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.By similarity

    Sequence similaritiesi

    Contains 1 ARID domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG248805.
    GeneTreeiENSGT00510000046413.
    HOVERGENiHBG058247.
    InParanoidiB2RQ67.
    OMAiFRLVHKL.
    OrthoDBiEOG7PVWNP.
    PhylomeDBiA2CG63.
    TreeFamiTF106427.

    Family and domain databases

    Gene3Di1.10.150.60. 1 hit.
    InterProiIPR001606. ARID/BRIGHT_DNA-bd.
    IPR028853. ARID4B.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR012603. RBB1NT.
    IPR002999. Tudor.
    IPR025995. Tudor-knot.
    [Graphical view]
    PANTHERiPTHR13964:SF21. PTHR13964:SF21. 1 hit.
    PfamiPF01388. ARID. 1 hit.
    PF08169. RBB1NT. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view]
    SMARTiSM00501. BRIGHT. 1 hit.
    SM00298. CHROMO. 1 hit.
    SM00333. TUDOR. 2 hits.
    [Graphical view]
    SUPFAMiSSF46774. SSF46774. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEiPS51011. ARID. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: A2CG63-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE     50
    VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT 100
    LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP 150
    EEESSSSSSD DDEEERKQTD ELLGKVVCVD YVSLEKKKAM WFPALVVCPD 200
    CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTVPK PDAVLKQAFD 250
    QALEFHKSRA IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE 300
    EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL 350
    GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA 400
    NIDFQMALPE KVLNKPCKDC ENKEVKVKEE SETEIKEVNV EDSKNVMPKE 450
    ETPAEDESER KENIKPSLGS KKSLLECIPA QSDEEKEAHI TKLEENENLE 500
    DKDGGRARTE EAFSTEVDGE EEQARSGDET NKEEDEDDEE IEEEEEEDEE 550
    EDEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG 600
    EALYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD 650
    RDEKYSPKNC KLRRLSKSPF QSNPSPEMVS KLDLADAKNS DTAHIKSIEI 700
    TSILNGLQAS ESSAEDSEQE DERCTQDVDN IGKDESKVEH STHSRNELIS 750
    KEEQSSPSLL EENKVHTDLV IAKTVSKSPE RLRKDMEAIS EDTDFEEEDE 800
    ITKKRKDVKK DTTDKALKPQ TKRGKRRYCS ADECLQTGSP GKKEDRTKSK 850
    EPLCTENSSN SSSDEDEEEK SKAKMTPTKK YNGLEEKRKS LRTTSFYSGF 900
    SEVAEKRIKL LNNSDERLQN NRAKDRKDVW SSIQGQWPKK TLKELFSDSD 950
    TEAAASPPHP APDEGAVEES LQTVAEEESC SPIMELEKPL PASVDNKPIE 1000
    EKPLEVSDRK TEFPSSGSNS VLNTPPTTPE SPSSVTITEA SQQQSSVTVS 1050
    VPLPPNQEEV RSIKSETDST IEVDSVVGEL QDLQSEGNSS PAGFDASVSS 1100
    SSSNQPEPDN PEKACTGQKR VKDTQGVGSS SKKQKRSHKA TVVNNKKKGK 1150
    GTNSSDSEEL SAGESVTKTQ TIKSVPTGMK THNSKSPARV QSPGKGGRNG 1200
    DKDPDLKEPS NRLPKVYKWS FQTSDLENMT SAERISILQE KLQEIRKHYL 1250
    SLKSEVASID RRRKRLKKKE RESAATSSSS SSPSSSSITA AVMLTLAEPS 1300
    MSSASQNGMS VECR 1314
    Length:1,314
    Mass (Da):147,643
    Last modified:February 20, 2007 - v1
    Checksum:iDE5E69DAA208A200
    GO
    Isoform 2 (identifier: A2CG63-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         528-614: Missing.

    Show »
    Length:1,227
    Mass (Da):137,325
    Checksum:i28B18F3DB2D6884D
    GO

    Sequence cautioni

    The sequence CAM21242.1 differs from that shown. Reason: Erroneous gene model prediction.

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei528 – 61487Missing in isoform 2. CuratedVSP_024236Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT025604 Genomic DNA. Translation: CAM21242.1. Sequence problems.
    CT025604 Genomic DNA. Translation: CAM21243.1.
    CT025604 Genomic DNA. Translation: CAM21244.1.
    CT025604 Genomic DNA. Translation: CAM21245.1.
    BC137783 mRNA. Translation: AAI37784.1.
    AK031062 mRNA. Translation: BAC27233.1.
    AK041414 mRNA. Translation: BAC30936.1.
    CCDSiCCDS36599.1. [A2CG63-1]
    CCDS36600.1. [A2CG63-2]
    RefSeqiNP_919238.1. NM_194262.2. [A2CG63-1]
    NP_937755.1. NM_198122.2. [A2CG63-2]
    XP_006516869.1. XM_006516806.1. [A2CG63-1]
    XP_006516870.1. XM_006516807.1. [A2CG63-1]
    UniGeneiMm.439784.

    Genome annotation databases

    EnsembliENSMUST00000039538; ENSMUSP00000043889; ENSMUSG00000039219. [A2CG63-2]
    ENSMUST00000110534; ENSMUSP00000106163; ENSMUSG00000039219. [A2CG63-1]
    ENSMUST00000110536; ENSMUSP00000106165; ENSMUSG00000039219. [A2CG63-2]
    GeneIDi94246.
    KEGGimmu:94246.
    UCSCiuc007pmz.1. mouse. [A2CG63-1]
    uc007pna.1. mouse. [A2CG63-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CT025604 Genomic DNA. Translation: CAM21242.1 . Sequence problems.
    CT025604 Genomic DNA. Translation: CAM21243.1 .
    CT025604 Genomic DNA. Translation: CAM21244.1 .
    CT025604 Genomic DNA. Translation: CAM21245.1 .
    BC137783 mRNA. Translation: AAI37784.1 .
    AK031062 mRNA. Translation: BAC27233.1 .
    AK041414 mRNA. Translation: BAC30936.1 .
    CCDSi CCDS36599.1. [A2CG63-1 ]
    CCDS36600.1. [A2CG63-2 ]
    RefSeqi NP_919238.1. NM_194262.2. [A2CG63-1 ]
    NP_937755.1. NM_198122.2. [A2CG63-2 ]
    XP_006516869.1. XM_006516806.1. [A2CG63-1 ]
    XP_006516870.1. XM_006516807.1. [A2CG63-1 ]
    UniGenei Mm.439784.

    3D structure databases

    ProteinModelPortali A2CG63.
    SMRi A2CG63. Positions 5-121, 170-271, 301-402, 564-632.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 220492. 2 interactions.
    IntActi A2CG63. 1 interaction.

    PTM databases

    PhosphoSitei A2CG63.

    Proteomic databases

    PaxDbi A2CG63.
    PRIDEi A2CG63.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000039538 ; ENSMUSP00000043889 ; ENSMUSG00000039219 . [A2CG63-2 ]
    ENSMUST00000110534 ; ENSMUSP00000106163 ; ENSMUSG00000039219 . [A2CG63-1 ]
    ENSMUST00000110536 ; ENSMUSP00000106165 ; ENSMUSG00000039219 . [A2CG63-2 ]
    GeneIDi 94246.
    KEGGi mmu:94246.
    UCSCi uc007pmz.1. mouse. [A2CG63-1 ]
    uc007pna.1. mouse. [A2CG63-2 ]

    Organism-specific databases

    CTDi 51742.
    MGIi MGI:2137512. Arid4b.

    Phylogenomic databases

    eggNOGi NOG248805.
    GeneTreei ENSGT00510000046413.
    HOVERGENi HBG058247.
    InParanoidi B2RQ67.
    OMAi FRLVHKL.
    OrthoDBi EOG7PVWNP.
    PhylomeDBi A2CG63.
    TreeFami TF106427.

    Miscellaneous databases

    ChiTaRSi ARID4B. mouse.
    NextBioi 352259.
    PROi A2CG63.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2CG63.
    Bgeei A2CG63.
    CleanExi MM_ARID4B.
    Genevestigatori A2CG63.

    Family and domain databases

    Gene3Di 1.10.150.60. 1 hit.
    InterProi IPR001606. ARID/BRIGHT_DNA-bd.
    IPR028853. ARID4B.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR012603. RBB1NT.
    IPR002999. Tudor.
    IPR025995. Tudor-knot.
    [Graphical view ]
    PANTHERi PTHR13964:SF21. PTHR13964:SF21. 1 hit.
    Pfami PF01388. ARID. 1 hit.
    PF08169. RBB1NT. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view ]
    SMARTi SM00501. BRIGHT. 1 hit.
    SM00298. CHROMO. 1 hit.
    SM00333. TUDOR. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46774. SSF46774. 1 hit.
    SSF54160. SSF54160. 1 hit.
    PROSITEi PS51011. ARID. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-531.
      Strain: C57BL/6J.
      Tissue: Forelimb and Thymus.

    Entry informationi

    Entry nameiARI4B_MOUSE
    AccessioniPrimary (citable) accession number: A2CG63
    Secondary accession number(s): A2CG61
    , A2CG62, A2CG64, B2RQ67, Q8BMI8, Q8BYA5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3