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A2CG63

- ARI4B_MOUSE

UniProt

A2CG63 - ARI4B_MOUSE

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Protein

AT-rich interactive domain-containing protein 4B

Gene

Arid4b

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes By similarity.By similarity

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW

GO - Biological processi

  1. establishment of Sertoli cell barrier Source: MGI
  2. histone H3-K9 trimethylation Source: MGI
  3. histone H4-K20 trimethylation Source: MGI
  4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  5. regulation of gene expression by genetic imprinting Source: MGI
  6. spermatogenesis Source: MGI
  7. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 4B
Short name:
ARID domain-containing protein 4B
Alternative name(s):
180 kDa Sin3-associated polypeptide
Short name:
Sin3-associated polypeptide p180
Histone deacetylase complex subunit SAP180
Gene namesi
Name:Arid4b
Synonyms:Sap180
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:2137512. Arid4b.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13141314AT-rich interactive domain-containing protein 4BPRO_0000282864Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei276 – 2761PhosphoserineBy similarity
Modified residuei666 – 6661PhosphoserineBy similarity
Modified residuei675 – 6751PhosphoserineBy similarity
Modified residuei717 – 7171PhosphoserineBy similarity
Modified residuei778 – 7781PhosphoserineBy similarity
Modified residuei790 – 7901PhosphoserineBy similarity
Modified residuei793 – 7931PhosphothreonineBy similarity
Modified residuei1016 – 10161PhosphoserineBy similarity
Modified residuei1028 – 10281PhosphothreonineBy similarity
Modified residuei1152 – 11521PhosphothreonineBy similarity
Modified residuei1154 – 11541PhosphoserineBy similarity
Modified residuei1155 – 11551PhosphoserineBy similarity
Modified residuei1157 – 11571PhosphoserineBy similarity
Modified residuei1161 – 11611PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiA2CG63.
PaxDbiA2CG63.
PRIDEiA2CG63.

PTM databases

PhosphoSiteiA2CG63.

Expressioni

Gene expression databases

BgeeiA2CG63.
CleanExiMM_ARID4B.
ExpressionAtlasiA2CG63. baseline and differential.
GenevestigatoriA2CG63.

Interactioni

Subunit structurei

Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Stra8P702784EBI-6394082,EBI-6394115

Protein-protein interaction databases

BioGridi220492. 2 interactions.
IntActiA2CG63. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliA2CG63.
SMRiA2CG63. Positions 5-121, 170-271, 301-402, 564-632.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini306 – 39893ARIDPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1227 – 127246Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 1596Poly-Ser
Compositional biasi268 – 567300Glu-richAdd
BLAST
Compositional biasi1097 – 11037Poly-Ser
Compositional biasi1273 – 130533Ser-richAdd
BLAST

Domaini

The C-terminus mediates interaction with mSin3A corepressor complex.By similarity
The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.By similarity
The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.By similarity

Sequence similaritiesi

Contains 1 ARID domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG248805.
GeneTreeiENSGT00510000046413.
HOVERGENiHBG058247.
InParanoidiA2CG63.
OMAiFRLVHKL.
OrthoDBiEOG7PVWNP.
PhylomeDBiA2CG63.
TreeFamiTF106427.

Family and domain databases

Gene3Di1.10.150.60. 1 hit.
InterProiIPR001606. ARID/BRIGHT_DNA-bd.
IPR028853. ARID4B.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR012603. RBB1NT.
IPR002999. Tudor.
IPR025995. Tudor-knot.
[Graphical view]
PANTHERiPTHR13964:SF21. PTHR13964:SF21. 1 hit.
PfamiPF01388. ARID. 1 hit.
PF08169. RBB1NT. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view]
SMARTiSM00501. BRIGHT. 1 hit.
SM00298. CHROMO. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view]
SUPFAMiSSF46774. SSF46774. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEiPS51011. ARID. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: A2CG63-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKALDEPPYL TVGTDVSAKY RGAFCEAKIK TAKRLVKVKV TFRHDSSTVE
60 70 80 90 100
VQDDHIKGPL KVGAIVEVKN LDGAYQEAVI NKLTDASWYT VVFDDGDEKT
110 120 130 140 150
LRRSSLCLKG ERHFAESETL DQLPLTNPEH FGTPVIGKKT NRGRRSNHIP
160 170 180 190 200
EEESSSSSSD DDEEERKQTD ELLGKVVCVD YVSLEKKKAM WFPALVVCPD
210 220 230 240 250
CSDEIAVKKD NILVRSFKDG KFTSVPRKDV HEITSDTVPK PDAVLKQAFD
260 270 280 290 300
QALEFHKSRA IPANWKTELK EDSSSSEAEE EEEEEDDEKE KEDNSSEEEE
310 320 330 340 350
EIEPFPEERE NFLQQLYKFM EDRGTPINKR PVLGYRNLNL FKLFRLVHKL
360 370 380 390 400
GGFDNIESGA VWKQVYQDLG IPVLNSAAGY NVKCAYKKYL YGFEEYCRSA
410 420 430 440 450
NIDFQMALPE KVLNKPCKDC ENKEVKVKEE SETEIKEVNV EDSKNVMPKE
460 470 480 490 500
ETPAEDESER KENIKPSLGS KKSLLECIPA QSDEEKEAHI TKLEENENLE
510 520 530 540 550
DKDGGRARTE EAFSTEVDGE EEQARSGDET NKEEDEDDEE IEEEEEEDEE
560 570 580 590 600
EDEDEDDDDN NEEEEFECYP PGMKVQVRYG RGKNQKMYEA SIKDSDVEGG
610 620 630 640 650
EALYLVHYCG WNVRYDEWIK ADKIVRPADK NVPKIKHRKK IKNKLDKEKD
660 670 680 690 700
RDEKYSPKNC KLRRLSKSPF QSNPSPEMVS KLDLADAKNS DTAHIKSIEI
710 720 730 740 750
TSILNGLQAS ESSAEDSEQE DERCTQDVDN IGKDESKVEH STHSRNELIS
760 770 780 790 800
KEEQSSPSLL EENKVHTDLV IAKTVSKSPE RLRKDMEAIS EDTDFEEEDE
810 820 830 840 850
ITKKRKDVKK DTTDKALKPQ TKRGKRRYCS ADECLQTGSP GKKEDRTKSK
860 870 880 890 900
EPLCTENSSN SSSDEDEEEK SKAKMTPTKK YNGLEEKRKS LRTTSFYSGF
910 920 930 940 950
SEVAEKRIKL LNNSDERLQN NRAKDRKDVW SSIQGQWPKK TLKELFSDSD
960 970 980 990 1000
TEAAASPPHP APDEGAVEES LQTVAEEESC SPIMELEKPL PASVDNKPIE
1010 1020 1030 1040 1050
EKPLEVSDRK TEFPSSGSNS VLNTPPTTPE SPSSVTITEA SQQQSSVTVS
1060 1070 1080 1090 1100
VPLPPNQEEV RSIKSETDST IEVDSVVGEL QDLQSEGNSS PAGFDASVSS
1110 1120 1130 1140 1150
SSSNQPEPDN PEKACTGQKR VKDTQGVGSS SKKQKRSHKA TVVNNKKKGK
1160 1170 1180 1190 1200
GTNSSDSEEL SAGESVTKTQ TIKSVPTGMK THNSKSPARV QSPGKGGRNG
1210 1220 1230 1240 1250
DKDPDLKEPS NRLPKVYKWS FQTSDLENMT SAERISILQE KLQEIRKHYL
1260 1270 1280 1290 1300
SLKSEVASID RRRKRLKKKE RESAATSSSS SSPSSSSITA AVMLTLAEPS
1310
MSSASQNGMS VECR
Length:1,314
Mass (Da):147,643
Last modified:February 20, 2007 - v1
Checksum:iDE5E69DAA208A200
GO
Isoform 2 (identifier: A2CG63-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-614: Missing.

Show »
Length:1,227
Mass (Da):137,325
Checksum:i28B18F3DB2D6884D
GO

Sequence cautioni

The sequence CAM21242.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei528 – 61487Missing in isoform 2. CuratedVSP_024236Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT025604 Genomic DNA. Translation: CAM21242.1. Sequence problems.
CT025604 Genomic DNA. Translation: CAM21243.1.
CT025604 Genomic DNA. Translation: CAM21244.1.
CT025604 Genomic DNA. Translation: CAM21245.1.
BC137783 mRNA. Translation: AAI37784.1.
AK031062 mRNA. Translation: BAC27233.1.
AK041414 mRNA. Translation: BAC30936.1.
CCDSiCCDS36599.1. [A2CG63-1]
CCDS36600.1. [A2CG63-2]
RefSeqiNP_919238.1. NM_194262.2. [A2CG63-1]
NP_937755.1. NM_198122.2. [A2CG63-2]
XP_006516869.1. XM_006516806.1. [A2CG63-1]
XP_006516870.1. XM_006516807.1. [A2CG63-1]
UniGeneiMm.439784.

Genome annotation databases

EnsembliENSMUST00000039538; ENSMUSP00000043889; ENSMUSG00000039219. [A2CG63-2]
ENSMUST00000110534; ENSMUSP00000106163; ENSMUSG00000039219. [A2CG63-1]
ENSMUST00000110536; ENSMUSP00000106165; ENSMUSG00000039219. [A2CG63-2]
GeneIDi94246.
KEGGimmu:94246.
UCSCiuc007pmz.1. mouse. [A2CG63-1]
uc007pna.1. mouse. [A2CG63-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CT025604 Genomic DNA. Translation: CAM21242.1 . Sequence problems.
CT025604 Genomic DNA. Translation: CAM21243.1 .
CT025604 Genomic DNA. Translation: CAM21244.1 .
CT025604 Genomic DNA. Translation: CAM21245.1 .
BC137783 mRNA. Translation: AAI37784.1 .
AK031062 mRNA. Translation: BAC27233.1 .
AK041414 mRNA. Translation: BAC30936.1 .
CCDSi CCDS36599.1. [A2CG63-1 ]
CCDS36600.1. [A2CG63-2 ]
RefSeqi NP_919238.1. NM_194262.2. [A2CG63-1 ]
NP_937755.1. NM_198122.2. [A2CG63-2 ]
XP_006516869.1. XM_006516806.1. [A2CG63-1 ]
XP_006516870.1. XM_006516807.1. [A2CG63-1 ]
UniGenei Mm.439784.

3D structure databases

ProteinModelPortali A2CG63.
SMRi A2CG63. Positions 5-121, 170-271, 301-402, 564-632.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 220492. 2 interactions.
IntActi A2CG63. 1 interaction.

PTM databases

PhosphoSitei A2CG63.

Proteomic databases

MaxQBi A2CG63.
PaxDbi A2CG63.
PRIDEi A2CG63.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039538 ; ENSMUSP00000043889 ; ENSMUSG00000039219 . [A2CG63-2 ]
ENSMUST00000110534 ; ENSMUSP00000106163 ; ENSMUSG00000039219 . [A2CG63-1 ]
ENSMUST00000110536 ; ENSMUSP00000106165 ; ENSMUSG00000039219 . [A2CG63-2 ]
GeneIDi 94246.
KEGGi mmu:94246.
UCSCi uc007pmz.1. mouse. [A2CG63-1 ]
uc007pna.1. mouse. [A2CG63-2 ]

Organism-specific databases

CTDi 51742.
MGIi MGI:2137512. Arid4b.

Phylogenomic databases

eggNOGi NOG248805.
GeneTreei ENSGT00510000046413.
HOVERGENi HBG058247.
InParanoidi A2CG63.
OMAi FRLVHKL.
OrthoDBi EOG7PVWNP.
PhylomeDBi A2CG63.
TreeFami TF106427.

Miscellaneous databases

ChiTaRSi ARID4B. mouse.
NextBioi 352259.
PROi A2CG63.
SOURCEi Search...

Gene expression databases

Bgeei A2CG63.
CleanExi MM_ARID4B.
ExpressionAtlasi A2CG63. baseline and differential.
Genevestigatori A2CG63.

Family and domain databases

Gene3Di 1.10.150.60. 1 hit.
InterProi IPR001606. ARID/BRIGHT_DNA-bd.
IPR028853. ARID4B.
IPR000953. Chromo_domain/shadow.
IPR016197. Chromodomain-like.
IPR012603. RBB1NT.
IPR002999. Tudor.
IPR025995. Tudor-knot.
[Graphical view ]
PANTHERi PTHR13964:SF21. PTHR13964:SF21. 1 hit.
Pfami PF01388. ARID. 1 hit.
PF08169. RBB1NT. 1 hit.
PF11717. Tudor-knot. 1 hit.
[Graphical view ]
SMARTi SM00501. BRIGHT. 1 hit.
SM00298. CHROMO. 1 hit.
SM00333. TUDOR. 2 hits.
[Graphical view ]
SUPFAMi SSF46774. SSF46774. 1 hit.
SSF54160. SSF54160. 1 hit.
PROSITEi PS51011. ARID. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-531.
    Strain: C57BL/6J.
    Tissue: Forelimb and Thymus.

Entry informationi

Entry nameiARI4B_MOUSE
AccessioniPrimary (citable) accession number: A2CG63
Secondary accession number(s): A2CG61
, A2CG62, A2CG64, B2RQ67, Q8BMI8, Q8BYA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3