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A2CG49

- KALRN_MOUSE

UniProt

A2CG49 - KALRN_MOUSE

Protein

Kalirin

Gene

Kalrn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity By similarity.By similarity

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.By similarity

    Cofactori

    Magnesium.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei2685 – 26851ATPBy similarityPROSITE-ProRule annotation
    Active sitei2775 – 27751Proton acceptorBy similarityPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi2662 – 26709ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. Rho guanyl-nucleotide exchange factor activity Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kalirin (EC:2.7.11.1)
    Alternative name(s):
    Protein Duo
    Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
    Gene namesi
    Name:KalrnImported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2685385. Kalrn.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. cytoskeleton Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 29642964KalirinPRO_0000308173Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1722 – 17221Phosphoserine1 Publication
    Modified residuei1725 – 17251PhosphoserineBy similarity
    Modified residuei1771 – 17711Phosphoserine1 Publication
    Modified residuei1789 – 17891PhosphoserineBy similarity
    Modified residuei2233 – 22331PhosphoserineBy similarity
    Disulfide bondi2464 ↔ 2520By similarityPROSITE-ProRule annotation

    Post-translational modificationi

    Autophosphorylated.By similarity

    Keywords - PTMi

    Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiA2CG49.
    PaxDbiA2CG49.
    PRIDEiA2CG49.

    PTM databases

    PhosphoSiteiA2CG49.

    Expressioni

    Gene expression databases

    ArrayExpressiA2CG49.
    BgeeiA2CG49.
    CleanExiMM_KALRN.
    GenevestigatoriA2CG49.

    Interactioni

    Subunit structurei

    Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG By similarity.By similarity

    Protein-protein interaction databases

    IntActiA2CG49. 5 interactions.

    Structurei

    Secondary structure

    1
    2964
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2296 – 22983
    Beta strandi2307 – 23093
    Beta strandi2318 – 23247
    Beta strandi2328 – 23347
    Beta strandi2338 – 234811
    Helixi2349 – 23513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1WFWNMR-A2295-2354[»]
    ProteinModelPortaliA2CG49.
    SMRiA2CG49. Positions 172-392, 784-971, 1252-1555, 1618-1684, 1890-2219, 2296-2361, 2429-2944.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiA2CG49.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 162146CRAL-TRIOPROSITE-ProRule annotationAdd
    BLAST
    Repeati170 – 290121Spectrin 1Sequence AnalysisAdd
    BLAST
    Repeati292 – 398107Spectrin 2Sequence AnalysisAdd
    BLAST
    Repeati518 – 624107Spectrin 3Sequence AnalysisAdd
    BLAST
    Repeati872 – 977106Spectrin 4Sequence AnalysisAdd
    BLAST
    Repeati1103 – 119593Spectrin 5Sequence AnalysisAdd
    BLAST
    Domaini1254 – 1429176DH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1441 – 1553113PH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1619 – 168466SH3 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1900 – 2075176DH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2087 – 2197111PH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2292 – 235766SH3 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini2443 – 253694Ig-like C2-typeSequence AnalysisAdd
    BLAST
    Domaini2543 – 263795Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST
    Domaini2656 – 2910255Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi664 – 6696Poly-GlnSequence Analysis

    Domaini

    The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity By similarity.By similarity

    Sequence similaritiesi

    Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
    Contains 2 DH (DBL-homology) domains.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
    Contains 2 PH domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 2 SH3 domains.PROSITE-ProRule annotation
    Contains 5 spectrin repeats.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00720000108506.
    HOVERGENiHBG108598.
    KOiK15048.
    OMAiDCFFPSG.
    PhylomeDBiA2CG49.
    TreeFamiTF318080.

    Family and domain databases

    Gene3Di1.20.900.10. 2 hits.
    2.30.29.30. 2 hits.
    2.60.40.10. 2 hits.
    3.40.525.10. 1 hit.
    InterProiIPR001251. CRAL-TRIO_dom.
    IPR000219. DH-domain.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR028569. Kalirin.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR001452. SH3_domain.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view]
    PANTHERiPTHR22826:SF49. PTHR22826:SF49. 1 hit.
    PfamiPF13716. CRAL_TRIO_2. 1 hit.
    PF00041. fn3. 1 hit.
    PF07679. I-set. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00621. RhoGEF. 2 hits.
    PF00018. SH3_1. 1 hit.
    PF00435. Spectrin. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00233. PH. 2 hits.
    SM00325. RhoGEF. 2 hits.
    SM00220. S_TKc. 1 hit.
    SM00516. SEC14. 1 hit.
    SM00326. SH3. 2 hits.
    SM00150. SPEC. 7 hits.
    [Graphical view]
    SUPFAMiSSF48065. SSF48065. 2 hits.
    SSF49265. SSF49265. 1 hit.
    SSF50044. SSF50044. 2 hits.
    SSF52087. SSF52087. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50191. CRAL_TRIO. 1 hit.
    PS50010. DH_2. 2 hits.
    PS50853. FN3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequences (9)i

    Sequence statusi: Complete.

    This entry describes 9 isoformsi produced by alternative splicing and alternative initiation. Align

    Isoform 1 (identifier: A2CG49-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARSNHDR     50
    IRQEDLRKLV TYLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA 100
    FPAEIHVALI IKPDNFWQKQ KTNFGSSKFI FETSMVSVEG LTKLVDPSQL 150
    TEEFDGSLDY NHEEWIELRL SLEEFFNSAV HLLSRLEDLQ EMLARKEFPV 200
    DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC SDGFSGRNCI 250
    PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD 300
    AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI 350
    NRIMSVASRL SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA 400
    VFHQKAEQFL SGVDAWCKMC SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY 450
    TEVSQDGKAL LDVLQRPLSP GNSESLTATA NYSKAVHQVL DVVHEVLHHQ 500
    RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA FLSKHTGVGK 550
    SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA 600
    ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV 650
    CADSVDAVQE LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP 700
    TEARDSAMSN NKTPHSSSIS HIESVLQQLD DAQVQMEELF HERKIKLDIF 750
    LQLRIFEQYT IEVTAELDAW NEDLLRQMND FNTEDLTLAE QRLQRHTERK 800
    LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDLDLA AQVQELLEFL 850
    HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV 900
    NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI 950
    RECAEKVALH WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR 1000
    RDEDWCGGRD KLGPAAEMDH VIPLLSKHLE QKEAFLKACT LARRNAEVFL 1050
    KYIHRNNVSM PSVASHTRGP EQQVKAILSE LLQRENRVLH FWTLKKRRLD 1100
    QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET QELLKEYGEF 1150
    RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM 1200
    GKYRYSLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEINEEKRK 1250
    SARKKEFIMA ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH 1300
    IIFGNIQEIY DFHNNIFLKE LEKYEQLPED VGHCFVTWAD KFQMYVTYCK 1350
    NKPDSNQLIL EHAGTFFDEI QQRHGLANSI SSYLIKPVQR VTKYQLLLKE 1400
    LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE NLDVQGELIL 1450
    QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL 1500
    TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE 1550
    VIQERIIHLK GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT 1600
    ISIASRTSQN TVESDKLSGG CELTVVLQDF SAGHSSELSI QVGQTVELLE 1650
    RPSERPGWCL VRTTERSPPQ EGLVPSSALC ISHSRSSVEM DCFFPLKDSY 1700
    SHSSSENGGK SESVAHLQSQ PSLNSIHSSP GPKRSTNTLK KWLTSPVRRL 1750
    NSGKADGNIK KQKKVRDGRK SFDLGSPKPG DETTPQGDSA DEKSKKGWGE 1800
    DEPDEESHTP LPPPMKIFDN DPTQDEMSSL LAARQAPPDV PTAADLVSAI 1850
    EKLVKNKLTL EGGSYRGSLK DPTGCLNEGM TPPTPPRNLE EEQKAKALRG 1900
    RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI EEKGVPEDMR GKEKIVFGNI 1950
    HQIYDWHKDF FLAELEKCIQ EQDRLAQLFI KHERKLHIYV WYCQNKPRSE 2000
    YIVAEYDAYF EEVKQEINQR LTLSDFLIKP IQRITKYQLL LKDFLRYSEK 2050
    AGLECSDIEK AVELMCLVPK RCNDMMNLGR LQGFEGTLTA QGKLLQQDTF 2100
    YVIELDAGMQ SRTKERRVFL FEQIVIFSEL LRKGSLTPGY MFKRSIKMNY 2150
    LVLEDNVDGD PCKFALMNRE TSERVILQAA NSDIQQAWVQ DINQVLETQR 2200
    DFLNALQSPI EYQRKERSTA VIRSQPPRVP QASPRPYSSG PVGSEKPPKG 2250
    SSYNPPLPPL KISTSNGSPG FDYHQPGDKF DASKQNDLGG CNGTSTMTVI 2300
    KDYYALKENE ICVSQGEVVQ VLAVNQQNMC LVYQPASDHS PAAEGWVPGS 2350
    ILAPLAKATA AAESSDGSIK KSCSWHTLRM RKRADVENSG KNEATGPRKP 2400
    KDILGNKVSV KETNSSEESE CDDLDPNTSM EILNPNFIQE VAPEFLVPLV 2450
    DVTCLLGDTV LLQCKACGRP KPSITWKGPD QNILDTDNSS ATYTISSCDS 2500
    GESTLKICNL MPQDSGIYTC IAANDHGTAS TSATVKVQGV PAAPNRPIAQ 2550
    ERSCTSVILR WLPPASTGNC TISGYTVEYR EEGSQVWQQS VASTLDTYLV 2600
    IEDLSPGCPY QFRVSASNPW GISLPSEPSE FVRLPEYDAA ADGATISWKE 2650
    NFDSAYTELN EIGRGRFSIV KKCIHKATRK DVAVKFVSKK MKKKEQAAHE 2700
    AALLQHLQHP QYVTLHDTYE SPTSYILILE LMDDGRLLDY LMNHDELMEE 2750
    KVAFYIRDIM EALQYLHNCR VAHLDIKPEN LLIDLRIPVP RVKLIDLEDA 2800
    VQISGHFHIH HLLGNPEFAA PEVIQGIPVS LGTDIWSIGV LTYVMLSGVS 2850
    PFLDESKEET CINVCRVDFS FPHEYFCGVS NAARDFINVI LQEDFRRRPT 2900
    AATCLQHPWL QPHNGSYSKI PLDTSRLACF IERRKHQNDV RPIPNVKSYI 2950
    VNRVNQGTSL SHNP 2964

    Note: Produced by alternative splicing.Curated

    Length:2,964
    Mass (Da):337,000
    Last modified:February 20, 2007 - v1
    Checksum:i76064FE06AA2BD9C
    GO
    Isoform 2 (identifier: A2CG49-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         2371-2375: KSCSW → TLLKP
         2376-2964: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.Curated

    Show »
    Length:2,375
    Mass (Da):271,141
    Checksum:i56F56B5B2D7DF990
    GO
    Isoform 31 Publication (identifier: A2CG49-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-2731: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.Curated

    Show »
    Length:233
    Mass (Da):26,709
    Checksum:i97FE34463CE6BF04
    GO
    Isoform 41 Publication (identifier: A2CG49-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1669: Missing.
         1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
         1828-1858: Missing.
         2285-2285: Missing.
         2372-2374: SCS → EPY
         2375-2964: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.Curated

    Show »
    Length:673
    Mass (Da):75,717
    Checksum:i1534A65BEB4A2EC6
    GO
    Isoform 51 Publication (identifier: A2CG49-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-623: Missing.
         923-923: E → ESLFHATSLQ
         1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
         1637-2964: Missing.

    Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.Curated

    Show »
    Length:1,022
    Mass (Da):117,971
    Checksum:iFDA70F10D8DAA1DC
    GO
    Isoform 61 Publication (identifier: A2CG49-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1669: Missing.
         1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
         2285-2285: Missing.
         2357-2364: KATAAAES → QSQSRGRK
         2365-2964: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.Curated

    Show »
    Length:694
    Mass (Da):78,009
    Checksum:iE610DD0659D34AC6
    GO
    Isoform 71 Publication (identifier: A2CG49-7) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
         1859-1898: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSSE...HPNFTNRNCI

    Note: Produced by alternative splicing.Curated

    Show »
    Length:2,984
    Mass (Da):338,885
    Checksum:i012852FBADE5C66B
    GO
    Isoform 81 Publication (identifier: A2CG49-8) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
         923-923: E → ESLFHATSLQ
         1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
         1637-2964: Missing.

    Note: Produced by alternative splicing. No experimental confirmation available.Curated

    Show »
    Length:1,663
    Mass (Da):192,182
    Checksum:i409352E757B550F5
    GO
    Isoform 91 Publication (identifier: A2CG49-9) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
         1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
         1637-2964: Missing.

    Note: Produced by alternative splicing.Curated

    Show »
    Length:1,654
    Mass (Da):191,197
    Checksum:i5EE5FD961CE9AB09
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1824 – 18241Q → H in BAC40535. (PubMed:16141072)Curated
    Sequence conflicti2316 – 23161G → S in BAB25925. (PubMed:16141072)Curated
    Sequence conflicti2344 – 23441E → K in BAB25925. (PubMed:16141072)Curated
    Sequence conflicti2355 – 23551L → F in BAB25925. (PubMed:16141072)Curated
    Isoform 51 Publication (identifier: A2CG49-5)
    Sequence conflicti711 – 7111E → K in BAE34776. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 27312731Missing in isoform 3. 1 PublicationVSP_052562Add
    BLAST
    Alternative sequencei1 – 16691669Missing in isoform 4 and isoform 6. 1 PublicationVSP_052563Add
    BLAST
    Alternative sequencei1 – 623623Missing in isoform 5. 1 PublicationVSP_052564Add
    BLAST
    Alternative sequencei1 – 44MVLS → MNPPEGASEEGGAADSDVDA FFRT in isoform 7. 1 PublicationVSP_052565
    Alternative sequencei1 – 44MVLS → MTDRFWDQWYLWYLRLLRLL DR in isoform 8 and isoform 9. 2 PublicationsVSP_052566
    Alternative sequencei923 – 9231E → ESLFHATSLQ in isoform 5 and isoform 8. 1 PublicationVSP_052567
    Alternative sequencei1617 – 163620LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 5, isoform 8 and isoform 9. 2 PublicationsVSP_052568Add
    BLAST
    Alternative sequencei1637 – 29641328Missing in isoform 5, isoform 8 and isoform 9. 2 PublicationsVSP_052569Add
    BLAST
    Alternative sequencei1670 – 169728QEGLV…FFPLK → MKGGDQAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationVSP_052570Add
    BLAST
    Alternative sequencei1828 – 185831Missing in isoform 4. 1 PublicationVSP_052571Add
    BLAST
    Alternative sequencei1859 – 189840TLEGG…KAKAL → VSGHAGGSSELPLTSVWLPG PQPGPRTGLPHPNFTNRNCI in isoform 7. 1 PublicationVSP_052572Add
    BLAST
    Alternative sequencei2285 – 22851Missing in isoform 4 and isoform 6. 1 PublicationVSP_052573
    Alternative sequencei2357 – 23648KATAAAES → QSQSRGRK in isoform 6. 1 PublicationVSP_052574
    Alternative sequencei2365 – 2964600Missing in isoform 6. 1 PublicationVSP_052575Add
    BLAST
    Alternative sequencei2371 – 23755KSCSW → TLLKP in isoform 2. 1 PublicationVSP_052576
    Alternative sequencei2372 – 23743SCS → EPY in isoform 4. 1 PublicationVSP_052577
    Alternative sequencei2375 – 2964590Missing in isoform 4. 1 PublicationVSP_052578Add
    BLAST
    Alternative sequencei2376 – 2964589Missing in isoform 2. 1 PublicationVSP_052579Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008844 mRNA. Translation: BAB25925.1.
    AK081504 mRNA. Translation: BAC38239.1.
    AK088732 mRNA. Translation: BAC40535.1.
    AK139581 mRNA. Translation: BAE24075.1.
    AK158544 mRNA. Translation: BAE34552.1.
    AK159031 mRNA. Translation: BAE34776.1.
    CT010573
    , AC154524, AC155257, AC165079 Genomic DNA. Translation: CAM18305.1.
    CT010573, AC154524, AC165079 Genomic DNA. Translation: CAM18306.1.
    CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18307.1.
    CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18308.1.
    CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18309.1.
    BC157950 mRNA. Translation: AAI57951.1.
    BC172101 mRNA. Translation: AAI72101.1.
    CCDSiCCDS49836.1. [A2CG49-9]
    RefSeqiNP_001157740.1. NM_001164268.1. [A2CG49-9]
    XP_006522445.1. XM_006522382.1. [A2CG49-8]
    UniGeneiMm.82274.

    Genome annotation databases

    EnsembliENSMUST00000076810; ENSMUSP00000076088; ENSMUSG00000061751. [A2CG49-1]
    ENSMUST00000089655; ENSMUSP00000087084; ENSMUSG00000061751. [A2CG49-8]
    ENSMUST00000114953; ENSMUSP00000110603; ENSMUSG00000061751. [A2CG49-5]
    ENSMUST00000114954; ENSMUSP00000110604; ENSMUSG00000061751. [A2CG49-5]
    ENSMUST00000114960; ENSMUSP00000110611; ENSMUSG00000061751. [A2CG49-9]
    GeneIDi545156.
    KEGGimmu:545156.
    UCSCiuc007zar.2. mouse. [A2CG49-3]
    uc007zas.1. mouse. [A2CG49-6]
    uc007zat.1. mouse. [A2CG49-4]
    uc007zav.1. mouse. [A2CG49-5]
    uc007zax.2. mouse. [A2CG49-9]
    uc012aew.1. mouse. [A2CG49-1]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK008844 mRNA. Translation: BAB25925.1 .
    AK081504 mRNA. Translation: BAC38239.1 .
    AK088732 mRNA. Translation: BAC40535.1 .
    AK139581 mRNA. Translation: BAE24075.1 .
    AK158544 mRNA. Translation: BAE34552.1 .
    AK159031 mRNA. Translation: BAE34776.1 .
    CT010573
    , AC154524 , AC155257 , AC165079 Genomic DNA. Translation: CAM18305.1 .
    CT010573 , AC154524 , AC165079 Genomic DNA. Translation: CAM18306.1 .
    CT010573 , AC154524 , AC154588 Genomic DNA. Translation: CAM18307.1 .
    CT010573 , AC154524 , AC154588 Genomic DNA. Translation: CAM18308.1 .
    CT010573 , AC154524 , AC154588 Genomic DNA. Translation: CAM18309.1 .
    BC157950 mRNA. Translation: AAI57951.1 .
    BC172101 mRNA. Translation: AAI72101.1 .
    CCDSi CCDS49836.1. [A2CG49-9 ]
    RefSeqi NP_001157740.1. NM_001164268.1. [A2CG49-9 ]
    XP_006522445.1. XM_006522382.1. [A2CG49-8 ]
    UniGenei Mm.82274.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1WFW NMR - A 2295-2354 [» ]
    ProteinModelPortali A2CG49.
    SMRi A2CG49. Positions 172-392, 784-971, 1252-1555, 1618-1684, 1890-2219, 2296-2361, 2429-2944.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi A2CG49. 5 interactions.

    PTM databases

    PhosphoSitei A2CG49.

    Proteomic databases

    MaxQBi A2CG49.
    PaxDbi A2CG49.
    PRIDEi A2CG49.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000076810 ; ENSMUSP00000076088 ; ENSMUSG00000061751 . [A2CG49-1 ]
    ENSMUST00000089655 ; ENSMUSP00000087084 ; ENSMUSG00000061751 . [A2CG49-8 ]
    ENSMUST00000114953 ; ENSMUSP00000110603 ; ENSMUSG00000061751 . [A2CG49-5 ]
    ENSMUST00000114954 ; ENSMUSP00000110604 ; ENSMUSG00000061751 . [A2CG49-5 ]
    ENSMUST00000114960 ; ENSMUSP00000110611 ; ENSMUSG00000061751 . [A2CG49-9 ]
    GeneIDi 545156.
    KEGGi mmu:545156.
    UCSCi uc007zar.2. mouse. [A2CG49-3 ]
    uc007zas.1. mouse. [A2CG49-6 ]
    uc007zat.1. mouse. [A2CG49-4 ]
    uc007zav.1. mouse. [A2CG49-5 ]
    uc007zax.2. mouse. [A2CG49-9 ]
    uc012aew.1. mouse. [A2CG49-1 ]

    Organism-specific databases

    CTDi 8997.
    MGIi MGI:2685385. Kalrn.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00720000108506.
    HOVERGENi HBG108598.
    KOi K15048.
    OMAi DCFFPSG.
    PhylomeDBi A2CG49.
    TreeFami TF318080.

    Enzyme and pathway databases

    Reactomei REACT_204733. G alpha (12/13) signalling events.
    REACT_207651. G alpha (q) signalling events.
    REACT_209641. NRAGE signals death through JNK.
    REACT_210090. Rho GTPase cycle.

    Miscellaneous databases

    ChiTaRSi KALRN. mouse.
    EvolutionaryTracei A2CG49.
    NextBioi 412318.
    PROi A2CG49.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi A2CG49.
    Bgeei A2CG49.
    CleanExi MM_KALRN.
    Genevestigatori A2CG49.

    Family and domain databases

    Gene3Di 1.20.900.10. 2 hits.
    2.30.29.30. 2 hits.
    2.60.40.10. 2 hits.
    3.40.525.10. 1 hit.
    InterProi IPR001251. CRAL-TRIO_dom.
    IPR000219. DH-domain.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR028569. Kalirin.
    IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR001452. SH3_domain.
    IPR018159. Spectrin/alpha-actinin.
    IPR002017. Spectrin_repeat.
    [Graphical view ]
    PANTHERi PTHR22826:SF49. PTHR22826:SF49. 1 hit.
    Pfami PF13716. CRAL_TRIO_2. 1 hit.
    PF00041. fn3. 1 hit.
    PF07679. I-set. 1 hit.
    PF00069. Pkinase. 1 hit.
    PF00621. RhoGEF. 2 hits.
    PF00018. SH3_1. 1 hit.
    PF00435. Spectrin. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 1 hit.
    SM00408. IGc2. 1 hit.
    SM00233. PH. 2 hits.
    SM00325. RhoGEF. 2 hits.
    SM00220. S_TKc. 1 hit.
    SM00516. SEC14. 1 hit.
    SM00326. SH3. 2 hits.
    SM00150. SPEC. 7 hits.
    [Graphical view ]
    SUPFAMi SSF48065. SSF48065. 2 hits.
    SSF49265. SSF49265. 1 hit.
    SSF50044. SSF50044. 2 hits.
    SSF52087. SSF52087. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50191. CRAL_TRIO. 1 hit.
    PS50010. DH_2. 2 hits.
    PS50853. FN3. 1 hit.
    PS50835. IG_LIKE. 1 hit.
    PS50003. PH_DOMAIN. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2108-2964 (ISOFORM 2).
      Strain: C57BL/6JImported and NODImported.
      Tissue: EggImported, Embryonic headImported, StomachImported, ThymusImported and Visual cortexImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
      Tissue: Brain.
    4. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 2034-2042, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1722 AND SER-1771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver1 Publication.

    Entry informationi

    Entry nameiKALRN_MOUSE
    AccessioniPrimary (citable) accession number: A2CG49
    Secondary accession number(s): A2CG50
    , A2CG51, A2CG52, A2CG53, B2RXR5, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3