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Protein

Kalirin

Gene

Kalrn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei2685 – 26851ATPPROSITE-ProRule annotationBy similarity
Active sitei2775 – 27751Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2662 – 26709ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_289095. NRAGE signals death through JNK.
REACT_297947. Rho GTPase cycle.
REACT_299052. G alpha (12/13) signalling events.
REACT_313804. EPHB-mediated forward signaling.
REACT_347934. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Kalirin (EC:2.7.11.1)
Alternative name(s):
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Gene namesi
Name:KalrnImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2685385. Kalrn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29642964KalirinPRO_0000308173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1722 – 17221Phosphoserine1 Publication
Modified residuei1725 – 17251PhosphoserineBy similarity
Modified residuei1771 – 17711Phosphoserine1 Publication
Modified residuei1789 – 17891PhosphoserineBy similarity
Modified residuei2233 – 22331PhosphoserineBy similarity
Disulfide bondi2464 ↔ 2520PROSITE-ProRule annotationBy similarity

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiA2CG49.
PaxDbiA2CG49.
PRIDEiA2CG49.

PTM databases

PhosphoSiteiA2CG49.

Expressioni

Gene expression databases

BgeeiA2CG49.
CleanExiMM_KALRN.
ExpressionAtlasiA2CG49. baseline and differential.
GenevisibleiA2CG49. MM.

Interactioni

Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG (By similarity).By similarity

Protein-protein interaction databases

IntActiA2CG49. 6 interactions.

Structurei

Secondary structure

1
2964
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2296 – 22983Combined sources
Beta strandi2307 – 23093Combined sources
Beta strandi2318 – 23247Combined sources
Beta strandi2328 – 23347Combined sources
Beta strandi2338 – 234811Combined sources
Helixi2349 – 23513Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFWNMR-A2295-2354[»]
ProteinModelPortaliA2CG49.
SMRiA2CG49. Positions 1252-1555, 1618-1684, 1890-2219, 2296-2361.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA2CG49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 162146CRAL-TRIOPROSITE-ProRule annotationAdd
BLAST
Repeati149 – 290142Spectrin 1Sequence AnalysisAdd
BLAST
Repeati292 – 399108Spectrin 2Sequence AnalysisAdd
BLAST
Repeati400 – 517118Spectrin 3Sequence AnalysisAdd
BLAST
Repeati518 – 621104Spectrin 4Sequence AnalysisAdd
BLAST
Repeati622 – 752131Spectrin 5Sequence AnalysisAdd
BLAST
Repeati753 – 870118Spectrin 6Sequence AnalysisAdd
BLAST
Repeati871 – 977107Spectrin 7Sequence AnalysisAdd
BLAST
Repeati978 – 1101124Spectrin 8Sequence AnalysisAdd
BLAST
Repeati1102 – 1207106Spectrin 9Sequence AnalysisAdd
BLAST
Domaini1254 – 1429176DH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1441 – 1553113PH 1PROSITE-ProRule annotationAdd
BLAST
Domaini1619 – 168466SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini1900 – 2075176DH 2PROSITE-ProRule annotationAdd
BLAST
Domaini2087 – 2197111PH 2PROSITE-ProRule annotationAdd
BLAST
Domaini2292 – 235766SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini2443 – 253694Ig-like C2-typeSequence AnalysisAdd
BLAST
Domaini2543 – 263795Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST
Domaini2656 – 2910255Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi664 – 6696Poly-GlnSequence Analysis

Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity (By similarity).By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.PROSITE-ProRule annotation
Contains 2 DH (DBL-homology) domains.PROSITE-ProRule annotation
Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
Contains 2 PH domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 2 SH3 domains.PROSITE-ProRule annotation
Contains 9 spectrin repeats.Sequence Analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119030.
HOVERGENiHBG108598.
InParanoidiA2CG49.
KOiK15048.
OMAiTVVLCCK.
PhylomeDBiA2CG49.
TreeFamiTF318080.

Family and domain databases

Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 1 hit.
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: A2CG49-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARSNHDR
60 70 80 90 100
IRQEDLRKLV TYLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA
110 120 130 140 150
FPAEIHVALI IKPDNFWQKQ KTNFGSSKFI FETSMVSVEG LTKLVDPSQL
160 170 180 190 200
TEEFDGSLDY NHEEWIELRL SLEEFFNSAV HLLSRLEDLQ EMLARKEFPV
210 220 230 240 250
DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC SDGFSGRNCI
260 270 280 290 300
PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD
310 320 330 340 350
AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI
360 370 380 390 400
NRIMSVASRL SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA
410 420 430 440 450
VFHQKAEQFL SGVDAWCKMC SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY
460 470 480 490 500
TEVSQDGKAL LDVLQRPLSP GNSESLTATA NYSKAVHQVL DVVHEVLHHQ
510 520 530 540 550
RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA FLSKHTGVGK
560 570 580 590 600
SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA
610 620 630 640 650
ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV
660 670 680 690 700
CADSVDAVQE LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP
710 720 730 740 750
TEARDSAMSN NKTPHSSSIS HIESVLQQLD DAQVQMEELF HERKIKLDIF
760 770 780 790 800
LQLRIFEQYT IEVTAELDAW NEDLLRQMND FNTEDLTLAE QRLQRHTERK
810 820 830 840 850
LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDLDLA AQVQELLEFL
860 870 880 890 900
HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV
910 920 930 940 950
NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI
960 970 980 990 1000
RECAEKVALH WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR
1010 1020 1030 1040 1050
RDEDWCGGRD KLGPAAEMDH VIPLLSKHLE QKEAFLKACT LARRNAEVFL
1060 1070 1080 1090 1100
KYIHRNNVSM PSVASHTRGP EQQVKAILSE LLQRENRVLH FWTLKKRRLD
1110 1120 1130 1140 1150
QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET QELLKEYGEF
1160 1170 1180 1190 1200
RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM
1210 1220 1230 1240 1250
GKYRYSLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEINEEKRK
1260 1270 1280 1290 1300
SARKKEFIMA ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH
1310 1320 1330 1340 1350
IIFGNIQEIY DFHNNIFLKE LEKYEQLPED VGHCFVTWAD KFQMYVTYCK
1360 1370 1380 1390 1400
NKPDSNQLIL EHAGTFFDEI QQRHGLANSI SSYLIKPVQR VTKYQLLLKE
1410 1420 1430 1440 1450
LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE NLDVQGELIL
1460 1470 1480 1490 1500
QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL
1510 1520 1530 1540 1550
TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE
1560 1570 1580 1590 1600
VIQERIIHLK GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT
1610 1620 1630 1640 1650
ISIASRTSQN TVESDKLSGG CELTVVLQDF SAGHSSELSI QVGQTVELLE
1660 1670 1680 1690 1700
RPSERPGWCL VRTTERSPPQ EGLVPSSALC ISHSRSSVEM DCFFPLKDSY
1710 1720 1730 1740 1750
SHSSSENGGK SESVAHLQSQ PSLNSIHSSP GPKRSTNTLK KWLTSPVRRL
1760 1770 1780 1790 1800
NSGKADGNIK KQKKVRDGRK SFDLGSPKPG DETTPQGDSA DEKSKKGWGE
1810 1820 1830 1840 1850
DEPDEESHTP LPPPMKIFDN DPTQDEMSSL LAARQAPPDV PTAADLVSAI
1860 1870 1880 1890 1900
EKLVKNKLTL EGGSYRGSLK DPTGCLNEGM TPPTPPRNLE EEQKAKALRG
1910 1920 1930 1940 1950
RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI EEKGVPEDMR GKEKIVFGNI
1960 1970 1980 1990 2000
HQIYDWHKDF FLAELEKCIQ EQDRLAQLFI KHERKLHIYV WYCQNKPRSE
2010 2020 2030 2040 2050
YIVAEYDAYF EEVKQEINQR LTLSDFLIKP IQRITKYQLL LKDFLRYSEK
2060 2070 2080 2090 2100
AGLECSDIEK AVELMCLVPK RCNDMMNLGR LQGFEGTLTA QGKLLQQDTF
2110 2120 2130 2140 2150
YVIELDAGMQ SRTKERRVFL FEQIVIFSEL LRKGSLTPGY MFKRSIKMNY
2160 2170 2180 2190 2200
LVLEDNVDGD PCKFALMNRE TSERVILQAA NSDIQQAWVQ DINQVLETQR
2210 2220 2230 2240 2250
DFLNALQSPI EYQRKERSTA VIRSQPPRVP QASPRPYSSG PVGSEKPPKG
2260 2270 2280 2290 2300
SSYNPPLPPL KISTSNGSPG FDYHQPGDKF DASKQNDLGG CNGTSTMTVI
2310 2320 2330 2340 2350
KDYYALKENE ICVSQGEVVQ VLAVNQQNMC LVYQPASDHS PAAEGWVPGS
2360 2370 2380 2390 2400
ILAPLAKATA AAESSDGSIK KSCSWHTLRM RKRADVENSG KNEATGPRKP
2410 2420 2430 2440 2450
KDILGNKVSV KETNSSEESE CDDLDPNTSM EILNPNFIQE VAPEFLVPLV
2460 2470 2480 2490 2500
DVTCLLGDTV LLQCKACGRP KPSITWKGPD QNILDTDNSS ATYTISSCDS
2510 2520 2530 2540 2550
GESTLKICNL MPQDSGIYTC IAANDHGTAS TSATVKVQGV PAAPNRPIAQ
2560 2570 2580 2590 2600
ERSCTSVILR WLPPASTGNC TISGYTVEYR EEGSQVWQQS VASTLDTYLV
2610 2620 2630 2640 2650
IEDLSPGCPY QFRVSASNPW GISLPSEPSE FVRLPEYDAA ADGATISWKE
2660 2670 2680 2690 2700
NFDSAYTELN EIGRGRFSIV KKCIHKATRK DVAVKFVSKK MKKKEQAAHE
2710 2720 2730 2740 2750
AALLQHLQHP QYVTLHDTYE SPTSYILILE LMDDGRLLDY LMNHDELMEE
2760 2770 2780 2790 2800
KVAFYIRDIM EALQYLHNCR VAHLDIKPEN LLIDLRIPVP RVKLIDLEDA
2810 2820 2830 2840 2850
VQISGHFHIH HLLGNPEFAA PEVIQGIPVS LGTDIWSIGV LTYVMLSGVS
2860 2870 2880 2890 2900
PFLDESKEET CINVCRVDFS FPHEYFCGVS NAARDFINVI LQEDFRRRPT
2910 2920 2930 2940 2950
AATCLQHPWL QPHNGSYSKI PLDTSRLACF IERRKHQNDV RPIPNVKSYI
2960
VNRVNQGTSL SHNP
Note: Produced by alternative splicing.Curated
Length:2,964
Mass (Da):337,000
Last modified:February 20, 2007 - v1
Checksum:i76064FE06AA2BD9C
GO
Isoform 2 (identifier: A2CG49-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2371-2375: KSCSW → TLLKP
     2376-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:2,375
Mass (Da):271,141
Checksum:i56F56B5B2D7DF990
GO
Isoform 31 Publication (identifier: A2CG49-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2731: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:233
Mass (Da):26,709
Checksum:i97FE34463CE6BF04
GO
Isoform 41 Publication (identifier: A2CG49-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1669: Missing.
     1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
     1828-1858: Missing.
     2285-2285: Missing.
     2372-2374: SCS → EPY
     2375-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:673
Mass (Da):75,717
Checksum:i1534A65BEB4A2EC6
GO
Isoform 51 Publication (identifier: A2CG49-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     923-923: E → ESLFHATSLQ
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.Curated
Show »
Length:1,022
Mass (Da):117,971
Checksum:iFDA70F10D8DAA1DC
GO
Isoform 61 Publication (identifier: A2CG49-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1669: Missing.
     1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
     2285-2285: Missing.
     2357-2364: KATAAAES → QSQSRGRK
     2365-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:694
Mass (Da):78,009
Checksum:iE610DD0659D34AC6
GO
Isoform 71 Publication (identifier: A2CG49-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
     1859-1898: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSSE...HPNFTNRNCI

Note: Produced by alternative splicing.Curated
Show »
Length:2,984
Mass (Da):338,885
Checksum:i012852FBADE5C66B
GO
Isoform 81 Publication (identifier: A2CG49-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     923-923: E → ESLFHATSLQ
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.Curated
Show »
Length:1,663
Mass (Da):192,182
Checksum:i409352E757B550F5
GO
Isoform 91 Publication (identifier: A2CG49-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative splicing.Curated
Show »
Length:1,654
Mass (Da):191,197
Checksum:i5EE5FD961CE9AB09
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1824 – 18241Q → H in BAC40535 (PubMed:16141072).Curated
Sequence conflicti2316 – 23161G → S in BAB25925 (PubMed:16141072).Curated
Sequence conflicti2344 – 23441E → K in BAB25925 (PubMed:16141072).Curated
Sequence conflicti2355 – 23551L → F in BAB25925 (PubMed:16141072).Curated
Isoform 51 Publication (identifier: A2CG49-5)
Sequence conflicti711 – 7111E → K in BAE34776 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 27312731Missing in isoform 3. 1 PublicationVSP_052562Add
BLAST
Alternative sequencei1 – 16691669Missing in isoform 4 and isoform 6. 1 PublicationVSP_052563Add
BLAST
Alternative sequencei1 – 623623Missing in isoform 5. 1 PublicationVSP_052564Add
BLAST
Alternative sequencei1 – 44MVLS → MNPPEGASEEGGAADSDVDA FFRT in isoform 7. 1 PublicationVSP_052565
Alternative sequencei1 – 44MVLS → MTDRFWDQWYLWYLRLLRLL DR in isoform 8 and isoform 9. 2 PublicationsVSP_052566
Alternative sequencei923 – 9231E → ESLFHATSLQ in isoform 5 and isoform 8. 1 PublicationVSP_052567
Alternative sequencei1617 – 163620LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 5, isoform 8 and isoform 9. 2 PublicationsVSP_052568Add
BLAST
Alternative sequencei1637 – 29641328Missing in isoform 5, isoform 8 and isoform 9. 2 PublicationsVSP_052569Add
BLAST
Alternative sequencei1670 – 169728QEGLV…FFPLK → MKGGDQAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationVSP_052570Add
BLAST
Alternative sequencei1828 – 185831Missing in isoform 4. 1 PublicationVSP_052571Add
BLAST
Alternative sequencei1859 – 189840TLEGG…KAKAL → VSGHAGGSSELPLTSVWLPG PQPGPRTGLPHPNFTNRNCI in isoform 7. 1 PublicationVSP_052572Add
BLAST
Alternative sequencei2285 – 22851Missing in isoform 4 and isoform 6. 1 PublicationVSP_052573
Alternative sequencei2357 – 23648KATAAAES → QSQSRGRK in isoform 6. 1 PublicationVSP_052574
Alternative sequencei2365 – 2964600Missing in isoform 6. 1 PublicationVSP_052575Add
BLAST
Alternative sequencei2371 – 23755KSCSW → TLLKP in isoform 2. 1 PublicationVSP_052576
Alternative sequencei2372 – 23743SCS → EPY in isoform 4. 1 PublicationVSP_052577
Alternative sequencei2375 – 2964590Missing in isoform 4. 1 PublicationVSP_052578Add
BLAST
Alternative sequencei2376 – 2964589Missing in isoform 2. 1 PublicationVSP_052579Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008844 mRNA. Translation: BAB25925.1.
AK081504 mRNA. Translation: BAC38239.1.
AK088732 mRNA. Translation: BAC40535.1.
AK139581 mRNA. Translation: BAE24075.1.
AK158544 mRNA. Translation: BAE34552.1.
AK159031 mRNA. Translation: BAE34776.1.
CT010573
, AC154524, AC155257, AC165079 Genomic DNA. Translation: CAM18305.1.
CT010573, AC154524, AC165079 Genomic DNA. Translation: CAM18306.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18307.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18308.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18309.1.
BC157950 mRNA. Translation: AAI57951.1.
BC172101 mRNA. Translation: AAI72101.1.
CCDSiCCDS49836.1. [A2CG49-9]
RefSeqiNP_001157740.1. NM_001164268.1. [A2CG49-9]
XP_006522445.1. XM_006522382.2. [A2CG49-8]
UniGeneiMm.82274.

Genome annotation databases

EnsembliENSMUST00000076810; ENSMUSP00000076088; ENSMUSG00000061751. [A2CG49-1]
ENSMUST00000089655; ENSMUSP00000087084; ENSMUSG00000061751. [A2CG49-8]
ENSMUST00000114953; ENSMUSP00000110603; ENSMUSG00000061751. [A2CG49-5]
ENSMUST00000114954; ENSMUSP00000110604; ENSMUSG00000061751. [A2CG49-5]
ENSMUST00000114960; ENSMUSP00000110611; ENSMUSG00000061751. [A2CG49-9]
GeneIDi545156.
KEGGimmu:545156.
UCSCiuc007zar.2. mouse. [A2CG49-3]
uc007zas.1. mouse. [A2CG49-6]
uc007zat.1. mouse. [A2CG49-4]
uc007zav.1. mouse. [A2CG49-5]
uc007zax.2. mouse. [A2CG49-9]
uc012aew.1. mouse. [A2CG49-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008844 mRNA. Translation: BAB25925.1.
AK081504 mRNA. Translation: BAC38239.1.
AK088732 mRNA. Translation: BAC40535.1.
AK139581 mRNA. Translation: BAE24075.1.
AK158544 mRNA. Translation: BAE34552.1.
AK159031 mRNA. Translation: BAE34776.1.
CT010573
, AC154524, AC155257, AC165079 Genomic DNA. Translation: CAM18305.1.
CT010573, AC154524, AC165079 Genomic DNA. Translation: CAM18306.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18307.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18308.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18309.1.
BC157950 mRNA. Translation: AAI57951.1.
BC172101 mRNA. Translation: AAI72101.1.
CCDSiCCDS49836.1. [A2CG49-9]
RefSeqiNP_001157740.1. NM_001164268.1. [A2CG49-9]
XP_006522445.1. XM_006522382.2. [A2CG49-8]
UniGeneiMm.82274.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFWNMR-A2295-2354[»]
ProteinModelPortaliA2CG49.
SMRiA2CG49. Positions 1252-1555, 1618-1684, 1890-2219, 2296-2361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiA2CG49. 6 interactions.

PTM databases

PhosphoSiteiA2CG49.

Proteomic databases

MaxQBiA2CG49.
PaxDbiA2CG49.
PRIDEiA2CG49.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076810; ENSMUSP00000076088; ENSMUSG00000061751. [A2CG49-1]
ENSMUST00000089655; ENSMUSP00000087084; ENSMUSG00000061751. [A2CG49-8]
ENSMUST00000114953; ENSMUSP00000110603; ENSMUSG00000061751. [A2CG49-5]
ENSMUST00000114954; ENSMUSP00000110604; ENSMUSG00000061751. [A2CG49-5]
ENSMUST00000114960; ENSMUSP00000110611; ENSMUSG00000061751. [A2CG49-9]
GeneIDi545156.
KEGGimmu:545156.
UCSCiuc007zar.2. mouse. [A2CG49-3]
uc007zas.1. mouse. [A2CG49-6]
uc007zat.1. mouse. [A2CG49-4]
uc007zav.1. mouse. [A2CG49-5]
uc007zax.2. mouse. [A2CG49-9]
uc012aew.1. mouse. [A2CG49-1]

Organism-specific databases

CTDi8997.
MGIiMGI:2685385. Kalrn.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119030.
HOVERGENiHBG108598.
InParanoidiA2CG49.
KOiK15048.
OMAiTVVLCCK.
PhylomeDBiA2CG49.
TreeFamiTF318080.

Enzyme and pathway databases

ReactomeiREACT_289095. NRAGE signals death through JNK.
REACT_297947. Rho GTPase cycle.
REACT_299052. G alpha (12/13) signalling events.
REACT_313804. EPHB-mediated forward signaling.
REACT_347934. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSiKalrn. mouse.
EvolutionaryTraceiA2CG49.
NextBioi412318.
PROiA2CG49.
SOURCEiSearch...

Gene expression databases

BgeeiA2CG49.
CleanExiMM_KALRN.
ExpressionAtlasiA2CG49. baseline and differential.
GenevisibleiA2CG49. MM.

Family and domain databases

Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 1 hit.
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2108-2964 (ISOFORM 2).
    Strain: C57BL/6JImported and NODImported.
    Tissue: EggImported, Embryonic headImported, StomachImported, ThymusImported and Visual cortexImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2034-2042, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1722 AND SER-1771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKALRN_MOUSE
AccessioniPrimary (citable) accession number: A2CG49
Secondary accession number(s): A2CG50
, A2CG51, A2CG52, A2CG53, B2RXR5, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: June 24, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.