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A2CG49

- KALRN_MOUSE

UniProt

A2CG49 - KALRN_MOUSE

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Protein

Kalirin

Gene
Kalrn
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity By similarity.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Magnesium By similarity.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei2685 – 26851ATP By similarityBy similarity
Active sitei2775 – 27751Proton acceptor By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi2662 – 26709ATP By similarityBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. Rho guanyl-nucleotide exchange factor activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Kalirin (EC:2.7.11.1)
Alternative name(s):
Protein Duo
Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
Gene namesi
Name:Kalrn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2685385. Kalrn.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 29642964KalirinPRO_0000308173Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1722 – 17221Phosphoserine1 Publication
Modified residuei1725 – 17251Phosphoserine By similarity
Modified residuei1771 – 17711Phosphoserine1 Publication
Modified residuei1789 – 17891Phosphoserine By similarity
Modified residuei2233 – 22331Phosphoserine By similarity
Disulfide bondi2464 ↔ 2520 By similarityBy similarity

Post-translational modificationi

Autophosphorylated By similarity.By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiA2CG49.
PaxDbiA2CG49.
PRIDEiA2CG49.

PTM databases

PhosphoSiteiA2CG49.

Expressioni

Gene expression databases

ArrayExpressiA2CG49.
BgeeiA2CG49.
CleanExiMM_KALRN.
GenevestigatoriA2CG49.

Interactioni

Subunit structurei

Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1). Interacts with FASLG By similarity.By similarity

Protein-protein interaction databases

IntActiA2CG49. 5 interactions.

Structurei

Secondary structure

1
2964
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2296 – 22983
Beta strandi2307 – 23093
Beta strandi2318 – 23247
Beta strandi2328 – 23347
Beta strandi2338 – 234811
Helixi2349 – 23513

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WFWNMR-A2295-2354[»]
ProteinModelPortaliA2CG49.
SMRiA2CG49. Positions 172-392, 784-971, 1252-1555, 1618-1684, 1890-2219, 2296-2361, 2429-2944.

Miscellaneous databases

EvolutionaryTraceiA2CG49.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 162146CRAL-TRIOAdd
BLAST
Repeati170 – 290121Spectrin 1Add
BLAST
Repeati292 – 398107Spectrin 2Add
BLAST
Repeati518 – 624107Spectrin 3Add
BLAST
Repeati872 – 977106Spectrin 4Add
BLAST
Repeati1103 – 119593Spectrin 5Add
BLAST
Domaini1254 – 1429176DH 1Add
BLAST
Domaini1441 – 1553113PH 1Add
BLAST
Domaini1619 – 168466SH3 1Add
BLAST
Domaini1900 – 2075176DH 2Add
BLAST
Domaini2087 – 2197111PH 2Add
BLAST
Domaini2292 – 235766SH3 2Add
BLAST
Domaini2443 – 253694Ig-like C2-typeAdd
BLAST
Domaini2543 – 263795Fibronectin type-IIIAdd
BLAST
Domaini2656 – 2910255Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi664 – 6696Poly-Gln

Domaini

The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity By similarity.By similarity

Sequence similaritiesi

Contains 1 CRAL-TRIO domain.
Contains 2 PH domains.
Contains 2 SH3 domains.
Contains 5 spectrin repeats.

Keywords - Domaini

Immunoglobulin domain, Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00720000108506.
HOVERGENiHBG108598.
KOiK15048.
OMAiDCFFPSG.
PhylomeDBiA2CG49.
TreeFamiTF318080.

Family and domain databases

Gene3Di1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProiIPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view]
PANTHERiPTHR22826:SF49. PTHR22826:SF49. 1 hit.
PfamiPF13716. CRAL_TRIO_2. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view]
SUPFAMiSSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform 11 Publication (identifier: A2CG49-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MVLSGSFRND GLKASDVLPI LKEKVAFVSG GRDKRGGPIL TFPARSNHDR     50
IRQEDLRKLV TYLASVPSED VCKRGFTVII DMRGSKWDLI KPLLKTLQEA 100
FPAEIHVALI IKPDNFWQKQ KTNFGSSKFI FETSMVSVEG LTKLVDPSQL 150
TEEFDGSLDY NHEEWIELRL SLEEFFNSAV HLLSRLEDLQ EMLARKEFPV 200
DVEGSRRLID EHTQLKKKVL KAPVEELDRE GQRLLQCIRC SDGFSGRNCI 250
PGSADFQSLV PKITSLLDKL HSTRQHLHQM WHVRKLKLDQ CFQLRLFEQD 300
AEKMFDWISH NKELFLQSHT EIGVSYQHAL DLQTQHNHFA MNSMNAYVNI 350
NRIMSVASRL SEAGHYASQQ IKQISTQLDQ EWKSFAAALD ERSTILAMSA 400
VFHQKAEQFL SGVDAWCKMC SEGGLPSEMQ DLELAIHHHQ SLYEQVTQAY 450
TEVSQDGKAL LDVLQRPLSP GNSESLTATA NYSKAVHQVL DVVHEVLHHQ 500
RRLESIWQHR KVRLHQRLQL CVFQQDVQQV LDWIENHGEA FLSKHTGVGK 550
SLHRARALQK RHDDFEEVAQ NTYTNADKLL EAAEQLAQTG ECDPEEIYKA 600
ARHLEVRIQD FVRRVEQRKL LLDMSVSFHT HTKELWTWME DLQKEVLEDV 650
CADSVDAVQE LIKQFQQQQT ATLDATLNVI KEGEDLIQQL RSAPPSLGEP 700
TEARDSAMSN NKTPHSSSIS HIESVLQQLD DAQVQMEELF HERKIKLDIF 750
LQLRIFEQYT IEVTAELDAW NEDLLRQMND FNTEDLTLAE QRLQRHTERK 800
LAMNNMTFEV IQQGQDLHQY IMEVQASGIE LICEKDLDLA AQVQELLEFL 850
HEKQHELELN AEQTHKRLEQ CLQLRHLQAE VKQVLGWIRN GESMLNASLV 900
NASSLSEAEQ LQREHEQFQL AIEKTHQSAL QVQQKAEALL QAGHYDADAI 950
RECAEKVALH WQQLMLKMED RLKLVNASVA FYKTSEQVCS VLESLEQEYR 1000
RDEDWCGGRD KLGPAAEMDH VIPLLSKHLE QKEAFLKACT LARRNAEVFL 1050
KYIHRNNVSM PSVASHTRGP EQQVKAILSE LLQRENRVLH FWTLKKRRLD 1100
QCQQYVVFER SAKQALDWIQ ETGEYYLSTH TSTGETTEET QELLKEYGEF 1150
RVPAKQTKEK VKLLIQLADS FVEKGHIHAT EIRKWVTTVD KHYRDFSLRM 1200
GKYRYSLEKA LGVNTEDNKD LELDIIPASL SDREVKLRDA NHEINEEKRK 1250
SARKKEFIMA ELLQTEKAYV RDLHECLETY LWEMTSGVEE IPPGILNKEH 1300
IIFGNIQEIY DFHNNIFLKE LEKYEQLPED VGHCFVTWAD KFQMYVTYCK 1350
NKPDSNQLIL EHAGTFFDEI QQRHGLANSI SSYLIKPVQR VTKYQLLLKE 1400
LLTCCEEGKG ELKDGLEVML SVPKKANDAM HVSMLEGFDE NLDVQGELIL 1450
QDAFQVWDPK SLIRKGRERH LFLFEISLVF SKEIKDSSGH TKYVYKNKLL 1500
TSELGVTEHV EGDPCKFALW SGRTPSSDNK TVLKASNIET KQEWIKNIRE 1550
VIQERIIHLK GALKEPIQLP KTPAKLRNNS KRDGVEDGDS QGDGSSQPDT 1600
ISIASRTSQN TVESDKLSGG CELTVVLQDF SAGHSSELSI QVGQTVELLE 1650
RPSERPGWCL VRTTERSPPQ EGLVPSSALC ISHSRSSVEM DCFFPLKDSY 1700
SHSSSENGGK SESVAHLQSQ PSLNSIHSSP GPKRSTNTLK KWLTSPVRRL 1750
NSGKADGNIK KQKKVRDGRK SFDLGSPKPG DETTPQGDSA DEKSKKGWGE 1800
DEPDEESHTP LPPPMKIFDN DPTQDEMSSL LAARQAPPDV PTAADLVSAI 1850
EKLVKNKLTL EGGSYRGSLK DPTGCLNEGM TPPTPPRNLE EEQKAKALRG 1900
RMFVLNELVQ TEKDYVKDLG IVVEGFMKRI EEKGVPEDMR GKEKIVFGNI 1950
HQIYDWHKDF FLAELEKCIQ EQDRLAQLFI KHERKLHIYV WYCQNKPRSE 2000
YIVAEYDAYF EEVKQEINQR LTLSDFLIKP IQRITKYQLL LKDFLRYSEK 2050
AGLECSDIEK AVELMCLVPK RCNDMMNLGR LQGFEGTLTA QGKLLQQDTF 2100
YVIELDAGMQ SRTKERRVFL FEQIVIFSEL LRKGSLTPGY MFKRSIKMNY 2150
LVLEDNVDGD PCKFALMNRE TSERVILQAA NSDIQQAWVQ DINQVLETQR 2200
DFLNALQSPI EYQRKERSTA VIRSQPPRVP QASPRPYSSG PVGSEKPPKG 2250
SSYNPPLPPL KISTSNGSPG FDYHQPGDKF DASKQNDLGG CNGTSTMTVI 2300
KDYYALKENE ICVSQGEVVQ VLAVNQQNMC LVYQPASDHS PAAEGWVPGS 2350
ILAPLAKATA AAESSDGSIK KSCSWHTLRM RKRADVENSG KNEATGPRKP 2400
KDILGNKVSV KETNSSEESE CDDLDPNTSM EILNPNFIQE VAPEFLVPLV 2450
DVTCLLGDTV LLQCKACGRP KPSITWKGPD QNILDTDNSS ATYTISSCDS 2500
GESTLKICNL MPQDSGIYTC IAANDHGTAS TSATVKVQGV PAAPNRPIAQ 2550
ERSCTSVILR WLPPASTGNC TISGYTVEYR EEGSQVWQQS VASTLDTYLV 2600
IEDLSPGCPY QFRVSASNPW GISLPSEPSE FVRLPEYDAA ADGATISWKE 2650
NFDSAYTELN EIGRGRFSIV KKCIHKATRK DVAVKFVSKK MKKKEQAAHE 2700
AALLQHLQHP QYVTLHDTYE SPTSYILILE LMDDGRLLDY LMNHDELMEE 2750
KVAFYIRDIM EALQYLHNCR VAHLDIKPEN LLIDLRIPVP RVKLIDLEDA 2800
VQISGHFHIH HLLGNPEFAA PEVIQGIPVS LGTDIWSIGV LTYVMLSGVS 2850
PFLDESKEET CINVCRVDFS FPHEYFCGVS NAARDFINVI LQEDFRRRPT 2900
AATCLQHPWL QPHNGSYSKI PLDTSRLACF IERRKHQNDV RPIPNVKSYI 2950
VNRVNQGTSL SHNP 2964

Note: Produced by alternative splicing.

Length:2,964
Mass (Da):337,000
Last modified:February 20, 2007 - v1
Checksum:i76064FE06AA2BD9C
GO
Isoform 21 Publication (identifier: A2CG49-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     2371-2375: KSCSW → TLLKP
     2376-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:2,375
Mass (Da):271,141
Checksum:i56F56B5B2D7DF990
GO
Isoform 31 Publication (identifier: A2CG49-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2731: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:233
Mass (Da):26,709
Checksum:i97FE34463CE6BF04
GO
Isoform 41 Publication (identifier: A2CG49-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1669: Missing.
     1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
     1828-1858: Missing.
     2285-2285: Missing.
     2372-2374: SCS → EPY
     2375-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:673
Mass (Da):75,717
Checksum:i1534A65BEB4A2EC6
GO
Isoform 51 Publication (identifier: A2CG49-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-623: Missing.
     923-923: E → ESLFHATSLQ
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative initiation at Met-624 of isoform 1. Inferred by similarity.

Show »
Length:1,022
Mass (Da):117,971
Checksum:iFDA70F10D8DAA1DC
GO
Isoform 61 Publication (identifier: A2CG49-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1669: Missing.
     1670-1697: QEGLVPSSALCISHSRSSVEMDCFFPLK → MKGGDQAYTRGPSLGWLFAKCCCCFPCR
     2285-2285: Missing.
     2357-2364: KATAAAES → QSQSRGRK
     2365-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:694
Mass (Da):78,009
Checksum:iE610DD0659D34AC6
GO
Isoform 71 Publication (identifier: A2CG49-7) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MNPPEGASEEGGAADSDVDAFFRT
     1859-1898: TLEGGSYRGS...LEEEQKAKAL → VSGHAGGSSE...HPNFTNRNCI

Note: Produced by alternative splicing.

Show »
Length:2,984
Mass (Da):338,885
Checksum:i012852FBADE5C66B
GO
Isoform 81 Publication (identifier: A2CG49-8) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     923-923: E → ESLFHATSLQ
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative splicing. No experimental confirmation available.

Show »
Length:1,663
Mass (Da):192,182
Checksum:i409352E757B550F5
GO
Isoform 91 Publication (identifier: A2CG49-9) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-4: MVLS → MTDRFWDQWYLWYLRLLRLLDR
     1617-1636: LSGGCELTVVLQDFSAGHSS → DGNLVPRWHLGPGDPFSTYV
     1637-2964: Missing.

Note: Produced by alternative splicing.

Show »
Length:1,654
Mass (Da):191,197
Checksum:i5EE5FD961CE9AB09
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 27312731Missing in isoform 3. 1 PublicationVSP_052562Add
BLAST
Alternative sequencei1 – 16691669Missing in isoform 4 and isoform 6. 1 PublicationVSP_052563Add
BLAST
Alternative sequencei1 – 623623Missing in isoform 5. 1 PublicationVSP_052564Add
BLAST
Alternative sequencei1 – 44MVLS → MNPPEGASEEGGAADSDVDA FFRT in isoform 7. 1 PublicationVSP_052565
Alternative sequencei1 – 44MVLS → MTDRFWDQWYLWYLRLLRLL DR in isoform 8 and isoform 9. 1 PublicationVSP_052566
Alternative sequencei923 – 9231E → ESLFHATSLQ in isoform 5 and isoform 8. 1 PublicationVSP_052567
Alternative sequencei1617 – 163620LSGGC…AGHSS → DGNLVPRWHLGPGDPFSTYV in isoform 5, isoform 8 and isoform 9. 1 PublicationVSP_052568Add
BLAST
Alternative sequencei1637 – 29641328Missing in isoform 5, isoform 8 and isoform 9. 1 PublicationVSP_052569Add
BLAST
Alternative sequencei1670 – 169728QEGLV…FFPLK → MKGGDQAYTRGPSLGWLFAK CCCCFPCR in isoform 4 and isoform 6. 1 PublicationVSP_052570Add
BLAST
Alternative sequencei1828 – 185831Missing in isoform 4. 1 PublicationVSP_052571Add
BLAST
Alternative sequencei1859 – 189840TLEGG…KAKAL → VSGHAGGSSELPLTSVWLPG PQPGPRTGLPHPNFTNRNCI in isoform 7. 1 PublicationVSP_052572Add
BLAST
Alternative sequencei2285 – 22851Missing in isoform 4 and isoform 6. 1 PublicationVSP_052573
Alternative sequencei2357 – 23648KATAAAES → QSQSRGRK in isoform 6. 1 PublicationVSP_052574
Alternative sequencei2365 – 2964600Missing in isoform 6. 1 PublicationVSP_052575Add
BLAST
Alternative sequencei2371 – 23755KSCSW → TLLKP in isoform 2. 1 PublicationVSP_052576
Alternative sequencei2372 – 23743SCS → EPY in isoform 4. 1 PublicationVSP_052577
Alternative sequencei2375 – 2964590Missing in isoform 4. 1 PublicationVSP_052578Add
BLAST
Alternative sequencei2376 – 2964589Missing in isoform 2. 1 PublicationVSP_052579Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1824 – 18241Q → H in BAC40535. 1 Publication
Sequence conflicti2316 – 23161G → S in BAB25925. 1 Publication
Sequence conflicti2344 – 23441E → K in BAB25925. 1 Publication
Sequence conflicti2355 – 23551L → F in BAB25925. 1 Publication
Isoform 51 Publication (identifier: A2CG49-5)
Sequence conflicti711 – 7111E → K in BAE34776. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008844 mRNA. Translation: BAB25925.1.
AK081504 mRNA. Translation: BAC38239.1.
AK088732 mRNA. Translation: BAC40535.1.
AK139581 mRNA. Translation: BAE24075.1.
AK158544 mRNA. Translation: BAE34552.1.
AK159031 mRNA. Translation: BAE34776.1.
CT010573
, AC154524, AC155257, AC165079 Genomic DNA. Translation: CAM18305.1.
CT010573, AC154524, AC165079 Genomic DNA. Translation: CAM18306.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18307.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18308.1.
CT010573, AC154524, AC154588 Genomic DNA. Translation: CAM18309.1.
BC157950 mRNA. Translation: AAI57951.1.
BC172101 mRNA. Translation: AAI72101.1.
CCDSiCCDS49836.1. [A2CG49-9]
RefSeqiNP_001157740.1. NM_001164268.1. [A2CG49-9]
XP_006522445.1. XM_006522382.1. [A2CG49-8]
UniGeneiMm.82274.

Genome annotation databases

EnsembliENSMUST00000076810; ENSMUSP00000076088; ENSMUSG00000061751. [A2CG49-1]
ENSMUST00000089655; ENSMUSP00000087084; ENSMUSG00000061751. [A2CG49-8]
ENSMUST00000114953; ENSMUSP00000110603; ENSMUSG00000061751. [A2CG49-5]
ENSMUST00000114954; ENSMUSP00000110604; ENSMUSG00000061751. [A2CG49-5]
ENSMUST00000114960; ENSMUSP00000110611; ENSMUSG00000061751. [A2CG49-9]
GeneIDi545156.
KEGGimmu:545156.
UCSCiuc007zar.2. mouse. [A2CG49-3]
uc007zas.1. mouse. [A2CG49-6]
uc007zat.1. mouse. [A2CG49-4]
uc007zav.1. mouse. [A2CG49-5]
uc007zax.2. mouse. [A2CG49-9]
uc012aew.1. mouse. [A2CG49-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK008844 mRNA. Translation: BAB25925.1 .
AK081504 mRNA. Translation: BAC38239.1 .
AK088732 mRNA. Translation: BAC40535.1 .
AK139581 mRNA. Translation: BAE24075.1 .
AK158544 mRNA. Translation: BAE34552.1 .
AK159031 mRNA. Translation: BAE34776.1 .
CT010573
, AC154524 , AC155257 , AC165079 Genomic DNA. Translation: CAM18305.1 .
CT010573 , AC154524 , AC165079 Genomic DNA. Translation: CAM18306.1 .
CT010573 , AC154524 , AC154588 Genomic DNA. Translation: CAM18307.1 .
CT010573 , AC154524 , AC154588 Genomic DNA. Translation: CAM18308.1 .
CT010573 , AC154524 , AC154588 Genomic DNA. Translation: CAM18309.1 .
BC157950 mRNA. Translation: AAI57951.1 .
BC172101 mRNA. Translation: AAI72101.1 .
CCDSi CCDS49836.1. [A2CG49-9 ]
RefSeqi NP_001157740.1. NM_001164268.1. [A2CG49-9 ]
XP_006522445.1. XM_006522382.1. [A2CG49-8 ]
UniGenei Mm.82274.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1WFW NMR - A 2295-2354 [» ]
ProteinModelPortali A2CG49.
SMRi A2CG49. Positions 172-392, 784-971, 1252-1555, 1618-1684, 1890-2219, 2296-2361, 2429-2944.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi A2CG49. 5 interactions.

PTM databases

PhosphoSitei A2CG49.

Proteomic databases

MaxQBi A2CG49.
PaxDbi A2CG49.
PRIDEi A2CG49.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000076810 ; ENSMUSP00000076088 ; ENSMUSG00000061751 . [A2CG49-1 ]
ENSMUST00000089655 ; ENSMUSP00000087084 ; ENSMUSG00000061751 . [A2CG49-8 ]
ENSMUST00000114953 ; ENSMUSP00000110603 ; ENSMUSG00000061751 . [A2CG49-5 ]
ENSMUST00000114954 ; ENSMUSP00000110604 ; ENSMUSG00000061751 . [A2CG49-5 ]
ENSMUST00000114960 ; ENSMUSP00000110611 ; ENSMUSG00000061751 . [A2CG49-9 ]
GeneIDi 545156.
KEGGi mmu:545156.
UCSCi uc007zar.2. mouse. [A2CG49-3 ]
uc007zas.1. mouse. [A2CG49-6 ]
uc007zat.1. mouse. [A2CG49-4 ]
uc007zav.1. mouse. [A2CG49-5 ]
uc007zax.2. mouse. [A2CG49-9 ]
uc012aew.1. mouse. [A2CG49-1 ]

Organism-specific databases

CTDi 8997.
MGIi MGI:2685385. Kalrn.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00720000108506.
HOVERGENi HBG108598.
KOi K15048.
OMAi DCFFPSG.
PhylomeDBi A2CG49.
TreeFami TF318080.

Enzyme and pathway databases

Reactomei REACT_204733. G alpha (12/13) signalling events.
REACT_207651. G alpha (q) signalling events.
REACT_209641. NRAGE signals death through JNK.
REACT_210090. Rho GTPase cycle.

Miscellaneous databases

ChiTaRSi KALRN. mouse.
EvolutionaryTracei A2CG49.
NextBioi 412318.
PROi A2CG49.
SOURCEi Search...

Gene expression databases

ArrayExpressi A2CG49.
Bgeei A2CG49.
CleanExi MM_KALRN.
Genevestigatori A2CG49.

Family and domain databases

Gene3Di 1.20.900.10. 2 hits.
2.30.29.30. 2 hits.
2.60.40.10. 2 hits.
3.40.525.10. 1 hit.
InterProi IPR001251. CRAL-TRIO_dom.
IPR000219. DH-domain.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR028569. Kalirin.
IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR001452. SH3_domain.
IPR018159. Spectrin/alpha-actinin.
IPR002017. Spectrin_repeat.
[Graphical view ]
PANTHERi PTHR22826:SF49. PTHR22826:SF49. 1 hit.
Pfami PF13716. CRAL_TRIO_2. 1 hit.
PF00041. fn3. 1 hit.
PF07679. I-set. 1 hit.
PF00069. Pkinase. 1 hit.
PF00621. RhoGEF. 2 hits.
PF00018. SH3_1. 1 hit.
PF00435. Spectrin. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
SM00233. PH. 2 hits.
SM00325. RhoGEF. 2 hits.
SM00220. S_TKc. 1 hit.
SM00516. SEC14. 1 hit.
SM00326. SH3. 2 hits.
SM00150. SPEC. 7 hits.
[Graphical view ]
SUPFAMi SSF48065. SSF48065. 2 hits.
SSF49265. SSF49265. 1 hit.
SSF50044. SSF50044. 2 hits.
SSF52087. SSF52087. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50191. CRAL_TRIO. 1 hit.
PS50010. DH_2. 2 hits.
PS50853. FN3. 1 hit.
PS50835. IG_LIKE. 1 hit.
PS50003. PH_DOMAIN. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5 AND 6), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2108-2964 (ISOFORM 2).
    Strain: C57BL/6J and NOD.
    Tissue: Egg, Embryonic head, Stomach, Thymus and Visual cortex.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 9).
    Tissue: Brain.
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2034-2042, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1722 AND SER-1771, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKALRN_MOUSE
AccessioniPrimary (citable) accession number: A2CG49
Secondary accession number(s): A2CG50
, A2CG51, A2CG52, A2CG53, B2RXR5, Q3TXY8, Q3TYL1, Q3UTA5, Q8BTT9, Q8C4Q2, Q9CVA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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