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Protein
Submitted name:

Neurogenic locus notch homolog protein 4

Gene

Notch4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1912420. Pre-NOTCH Processing in Golgi.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-350054. Notch-HLH transcription pathway.

Names & Taxonomyi

Protein namesi
Submitted name:
Neurogenic locus notch homolog protein 4Imported
Submitted name:
Notch gene homolog 4 (Drosophila)Imported
Gene namesi
Name:Notch4Imported
ORF Names:RP23-24A13.10-001Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107471. Notch4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1403 – 1421HelicalSequence analysisAdd BLAST19
Transmembranei1441 – 1464HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500875419021 – 1964Sequence analysisAdd BLAST1944

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000015468.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015612.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 60EGF-likeInterPro annotationAdd BLAST40
Domaini61 – 112EGF-likeInterPro annotationAdd BLAST52
Domaini115 – 152EGF-likeInterPro annotationAdd BLAST38
Domaini153 – 189EGF-likeInterPro annotationAdd BLAST37
Domaini191 – 229EGF-likeInterPro annotationAdd BLAST39
Domaini231 – 271EGF-likeInterPro annotationAdd BLAST41
Domaini273 – 309EGF-likeInterPro annotationAdd BLAST37
Domaini311 – 350EGF-likeInterPro annotationAdd BLAST40
Domaini352 – 388EGF-likeInterPro annotationAdd BLAST37
Domaini389 – 427EGF-likeInterPro annotationAdd BLAST39
Domaini429 – 470EGF-likeInterPro annotationAdd BLAST42
Domaini472 – 508EGF-likeInterPro annotationAdd BLAST37
Domaini510 – 546EGF-likeInterPro annotationAdd BLAST37
Domaini548 – 584EGF-likeInterPro annotationAdd BLAST37
Domaini586 – 622EGF-likeInterPro annotationAdd BLAST37
Domaini688 – 724EGF-likeInterPro annotationAdd BLAST37
Domaini726 – 762EGF-likeInterPro annotationAdd BLAST37
Domaini764 – 800EGF-likeInterPro annotationAdd BLAST37
Domaini803 – 839EGF-likeInterPro annotationAdd BLAST37
Domaini841 – 877EGF-likeInterPro annotationAdd BLAST37
Domaini889 – 924EGF-likeInterPro annotationAdd BLAST36
Domaini926 – 962EGF-likeInterPro annotationAdd BLAST37
Domaini964 – 1000EGF-likeInterPro annotationAdd BLAST37
Domaini1002 – 1040EGF-likeInterPro annotationAdd BLAST39
Domaini1042 – 1081EGF-likeInterPro annotationAdd BLAST40
Domaini1083 – 1122EGF-likeInterPro annotationAdd BLAST40
Domaini1126 – 1167EGF-likeInterPro annotationAdd BLAST42
Domaini1166 – 1209LNR (Lin/Notch)InterPro annotationAdd BLAST44
Domaini1210 – 1241LNR (Lin/Notch)InterPro annotationAdd BLAST32
Domaini1247 – 1287LNR (Lin/Notch)InterPro annotationAdd BLAST41
Domaini1606 – 1826ANK_REP_REGIONInterPro annotationAdd BLAST221

Sequence similaritiesi

Contains 5 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotation, EGF-like domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IR7G. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00810000125346.
HOVERGENiHBG052650.
KOiK02599.
OMAiDECQMAQ.
OrthoDBiEOG091G01NU.
TreeFamiTF351641.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00008. EGF. 17 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PRINTSiPR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTiSM00248. ANK. 6 hits.
SM00181. EGF. 28 hits.
SM00179. EGF_CA. 21 hits.
SM00004. NL. 3 hits.
SM01338. NOD. 1 hit.
SM01339. NODP. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 11 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2CG28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPQLLLLLL LPLNFPVILT RELLCGGSPE PCANGGTCLR LSRGQGICQC
60 70 80 90 100
APGFLGETCQ FPDPCRDTQL CKNGGSCQAL LPTPPSSRSP TSPLTPHFSC
110 120 130 140 150
TCPSGFTGDR CQTHLEELCP PSFCSNGGHC YVQASGRPQC SCEPGWTGEQ
160 170 180 190 200
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP PGFEGHTCER DINECFLEPG
210 220 230 240 250
PCPQGTSCHN TLGSYQCLCP VGQEGPQCKL RKGACPPGSC LNGGTCQLVP
260 270 280 290 300
EGHSTFHLCL CPPGFTGLDC EMNPDDCVRH QCQNGATCLD GLDTYTCLCP
310 320 330 340 350
KTWKGWDCSE DIDECEARGP PRCRNGGTCQ NTAGSFHCVC VSGWGGAGCE
360 370 380 390 400
ENLDDCAAAT CAPGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLSQPCHV
410 420 430 440 450
NAQCSTNPLT GSTLCICQPG YSGSTCHQDL DECQMAQQGP SPCEHGGSCI
460 470 480 490 500
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFHCLCPP
510 520 530 540 550
GLEGRLCEVE VNECTSNPCL NQAACHDLLN GFQCLCLPGF TGARCEKDMD
560 570 580 590 600
ECSSTPCANG GRCRDQPGAF YCECLPGFEG PHCEKEVDEC LSDPCPVGAS
610 620 630 640 650
CLDLPGAFFC LCRPGFTGQL CEVPLCTPNM CQPGQQCQGQ EHRAPCLCPD
660 670 680 690 700
GSPGCVPAED NCPCHHGHCQ RSLCVCDEGW TGPECETELG GCISTPCAHG
710 720 730 740 750
GTCHPQPSGY NCTCPAGYMG LTCSEEVTAC HSGPCLNGGS CSIRPEGYSC
760 770 780 790 800
TCLPSHTGRH CQTAVDHCVS ASCLNGGTCV NKPGTFFCLC ATGFQGLHCE
810 820 830 840 850
EKTNPSCADS PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC
860 870 880 890 900
PHTARCLQSG PSFQCLCLQG WTGALCDFPL SCQKAAMSQG IEISGLCQNG
910 920 930 940 950
GLCIDTGSSY FCRCPPGFQG KLCQDNVNPC EPNPCHHGST CVPQPSGYVC
960 970 980 990 1000
QCAPGYEGQN CSKVLDACQS QPCHNHGTCT SRPGGFHCAC PPGFVGLRCE
1010 1020 1030 1040 1050
GDVDECLDRP CHPSGTAACH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP
1060 1070 1080 1090 1100
CSNGGSCEIT TGPPPGFTCH CPKGFEGPTC SHKALSCGIH HCHNGGLCLP
1110 1120 1130 1140 1150
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCLHNG TCTETPGLGN
1160 1170 1180 1190 1200
PGFQCTCPPD SPGPRCQRPG ASGCEGRGGD GTCDAGCSGP GGDWDGGDCS
1210 1220 1230 1240 1250
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPLTCIPA
1260 1270 1280 1290 1300
YDQYCRDHFH NGHCEKGCNN AECGWDGGDC RPEGEDSEGR PSLALLVVLR
1310 1320 1330 1340 1350
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGA
1360 1370 1380 1390 1400
RDSSSWERQA PPTQPLGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPWD
1410 1420 1430 1440 1450
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTRPSANQ LPWPILCSPV
1460 1470 1480 1490 1500
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL
1510 1520 1530 1540 1550
GEDNIGLKAL KPEAEVDEDG VAMCSGPEEG EAEETASASR CQLWPLNSGC
1560 1570 1580 1590 1600
GELPQAAMLT PPQECESEVL DVDTCGPDGV TPLMSAVFCG GVQSTTGASP
1610 1620 1630 1640 1650
QRLGLGNLEP WEPLLDRGAC PQAHTVGTGE TPLHLAARFS RPTAARRLLE
1660 1670 1680 1690 1700
AGANPNQPDR AGRTPLHTAV AADAREVCQL LLASRQTTVD ARTEDGTTPL
1710 1720 1730 1740 1750
MLAARLAVED LVEELIAARA DVGARDKRGK TALHWAAAVN NARAARSLLQ
1760 1770 1780 1790 1800
AGADKDAQDS REQTPLFLAA REGAVEVAQL LLELGAARGL RDQAGLAPGD
1810 1820 1830 1840 1850
VARQRSHWDL LTLLEGAGPT TQEARAHART TPGGGAAPRC RTLSAGARPR
1860 1870 1880 1890 1900
GGGACLQART WSVDLGARGG KVYARCRSRS GSCGGPTTRG RRFSAGSRGR
1910 1920 1930 1940 1950
RGARASQDDW PRDWVALEAC GSACSAPIPP PSLTPSPERG SPQVAWGLPV
1960
HQEIPLNSVV RNLN
Length:1,964
Mass (Da):206,702
Last modified:February 20, 2007 - v1
Checksum:i53D7F86394FC40BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA. Translation: CAM18615.1.
RefSeqiNP_035059.2. NM_010929.2.
UniGeneiMm.173813.

Genome annotation databases

EnsembliENSMUST00000015612; ENSMUSP00000015612; ENSMUSG00000015468.
GeneIDi18132.
KEGGimmu:18132.
UCSCiuc008ccs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA. Translation: CAM18615.1.
RefSeqiNP_035059.2. NM_010929.2.
UniGeneiMm.173813.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000015612.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015612; ENSMUSP00000015612; ENSMUSG00000015468.
GeneIDi18132.
KEGGimmu:18132.
UCSCiuc008ccs.1. mouse.

Organism-specific databases

CTDi4855.
MGIiMGI:107471. Notch4.

Phylogenomic databases

eggNOGiENOG410IR7G. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00810000125346.
HOVERGENiHBG052650.
KOiK02599.
OMAiDECQMAQ.
OrthoDBiEOG091G01NU.
TreeFamiTF351641.

Enzyme and pathway databases

ReactomeiR-MMU-1912420. Pre-NOTCH Processing in Golgi.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-350054. Notch-HLH transcription pathway.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015468.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR022355. Notch_4.
IPR000800. Notch_dom.
IPR010660. Notch_NOD_dom.
IPR011656. Notch_NODP_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
PF00008. EGF. 17 hits.
PF07645. EGF_CA. 3 hits.
PF12661. hEGF. 3 hits.
PF07684. NODP. 1 hit.
PF00066. Notch. 3 hits.
[Graphical view]
PRINTSiPR01452. LNOTCHREPEAT.
PR01987. NOTCH4.
SMARTiSM00248. ANK. 6 hits.
SM00181. EGF. 28 hits.
SM00179. EGF_CA. 21 hits.
SM00004. NL. 3 hits.
SM01338. NOD. 1 hit.
SM01339. NODP. 1 hit.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF57184. SSF57184. 5 hits.
SSF90193. SSF90193. 2 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 5 hits.
PS00010. ASX_HYDROXYL. 11 hits.
PS00022. EGF_1. 28 hits.
PS01186. EGF_2. 21 hits.
PS50026. EGF_3. 27 hits.
PS01187. EGF_CA. 9 hits.
PS50258. LNR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2CG28_MOUSE
AccessioniPrimary (citable) accession number: A2CG28
Entry historyi
Integrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 30, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.