Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Neurogenic locus notch homolog protein 4

Gene

Notch4

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi452Calcium 1; via carbonyl oxygenUniRule annotation1
Metal bindingi455Calcium 1; via amide nitrogenUniRule annotation1
Metal bindingi472Calcium 2UniRule annotation1
Metal bindingi475Calcium 2UniRule annotation1
Metal bindingi489Calcium 2UniRule annotation1
Metal bindingi513Calcium 3UniRule annotation1
Metal bindingi527Calcium 3UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalciumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-1912420 Pre-NOTCH Processing in Golgi
R-MMU-1980150 Signaling by NOTCH4
R-MMU-350054 Notch-HLH transcription pathway

Names & Taxonomyi

Protein namesi
Submitted name:
Neurogenic locus notch homolog protein 4Imported
Submitted name:
Notch gene homolog 4 (Drosophila)Imported
Gene namesi
Name:Notch4Imported
ORF Names:RP23-24A13.10-001Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:107471 Notch4

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1403 – 1421HelicalSequence analysisAdd BLAST19
Transmembranei1441 – 1464HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501408346921 – 1964Sequence analysisAdd BLAST1944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 59PROSITE-ProRule annotation
Disulfide bondi102 ↔ 111PROSITE-ProRule annotation
Disulfide bondi142 ↔ 151PROSITE-ProRule annotation
Disulfide bondi179 ↔ 188PROSITE-ProRule annotation
Disulfide bondi219 ↔ 228PROSITE-ProRule annotation
Disulfide bondi261 ↔ 270PROSITE-ProRule annotation
Disulfide bondi299 ↔ 308PROSITE-ProRule annotation
Disulfide bondi340 ↔ 349PROSITE-ProRule annotation
Disulfide bondi378 ↔ 387PROSITE-ProRule annotation
Disulfide bondi398 ↔ 415PROSITE-ProRule annotation
Disulfide bondi417 ↔ 426PROSITE-ProRule annotation
Disulfide bondi433 ↔ 449UniRule annotation
Disulfide bondi443 ↔ 458UniRule annotation
Disulfide bondi460 ↔ 469UniRule annotation
Disulfide bondi476 ↔ 487UniRule annotation
Disulfide bondi481 ↔ 496UniRule annotation
Disulfide bondi498 ↔ 507UniRule annotation
Disulfide bondi514 ↔ 525UniRule annotation
Disulfide bondi519 ↔ 534UniRule annotation
Disulfide bondi536 ↔ 545UniRule annotation
Disulfide bondi574 ↔ 583PROSITE-ProRule annotation
Disulfide bondi612 ↔ 621PROSITE-ProRule annotation
Disulfide bondi714 ↔ 723PROSITE-ProRule annotation
Disulfide bondi752 ↔ 761PROSITE-ProRule annotation
Disulfide bondi790 ↔ 799PROSITE-ProRule annotation
Disulfide bondi829 ↔ 838PROSITE-ProRule annotation
Disulfide bondi867 ↔ 876PROSITE-ProRule annotation
Disulfide bondi893 ↔ 903PROSITE-ProRule annotation
Disulfide bondi914 ↔ 923PROSITE-ProRule annotation
Disulfide bondi952 ↔ 961PROSITE-ProRule annotation
Disulfide bondi990 ↔ 999PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1028PROSITE-ProRule annotation
Disulfide bondi1030 ↔ 1039PROSITE-ProRule annotation
Disulfide bondi1071 ↔ 1080PROSITE-ProRule annotation
Disulfide bondi1112 ↔ 1121PROSITE-ProRule annotation
Disulfide bondi1157 ↔ 1166PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Proteomic databases

MaxQBiA2CG28

Expressioni

Gene expression databases

BgeeiENSMUSG00000015468

Structurei

3D structure databases

SMRiA2CG28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 60EGF-likeInterPro annotationAdd BLAST40
Domaini61 – 112EGF-likeInterPro annotationAdd BLAST52
Domaini115 – 152EGF-likeInterPro annotationAdd BLAST38
Domaini153 – 189EGF-likeInterPro annotationAdd BLAST37
Domaini191 – 229EGF-likeInterPro annotationAdd BLAST39
Domaini231 – 271EGF-likeInterPro annotationAdd BLAST41
Domaini273 – 309EGF-likeInterPro annotationAdd BLAST37
Domaini311 – 350EGF-likeInterPro annotationAdd BLAST40
Domaini352 – 388EGF-likeInterPro annotationAdd BLAST37
Domaini389 – 427EGF-likeInterPro annotationAdd BLAST39
Domaini429 – 470EGF-likeInterPro annotationAdd BLAST42
Domaini472 – 508EGF-likeInterPro annotationAdd BLAST37
Domaini510 – 546EGF-likeInterPro annotationAdd BLAST37
Domaini548 – 584EGF-likeInterPro annotationAdd BLAST37
Domaini586 – 622EGF-likeInterPro annotationAdd BLAST37
Domaini688 – 724EGF-likeInterPro annotationAdd BLAST37
Domaini726 – 762EGF-likeInterPro annotationAdd BLAST37
Domaini764 – 800EGF-likeInterPro annotationAdd BLAST37
Domaini803 – 839EGF-likeInterPro annotationAdd BLAST37
Domaini841 – 877EGF-likeInterPro annotationAdd BLAST37
Domaini889 – 924EGF-likeInterPro annotationAdd BLAST36
Domaini926 – 962EGF-likeInterPro annotationAdd BLAST37
Domaini964 – 1000EGF-likeInterPro annotationAdd BLAST37
Domaini1002 – 1040EGF-likeInterPro annotationAdd BLAST39
Domaini1042 – 1081EGF-likeInterPro annotationAdd BLAST40
Domaini1083 – 1122EGF-likeInterPro annotationAdd BLAST40
Domaini1126 – 1167EGF-likeInterPro annotationAdd BLAST42
Domaini1166 – 1209LNRInterPro annotationAdd BLAST44
Domaini1210 – 1241LNRInterPro annotationAdd BLAST32
Domaini1247 – 1287LNRInterPro annotationAdd BLAST41
Domaini1606 – 1826ANK_REP_REGIONInterPro annotationAdd BLAST221
Repeati1628 – 1660ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1661 – 1682ANKPROSITE-ProRule annotationAdd BLAST22
Repeati1695 – 1727ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1728 – 1760ANKPROSITE-ProRule annotationAdd BLAST33
Repeati1761 – 1793ANKPROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

ANK repeatPROSITE-ProRule annotation, EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IR7G Eukaryota
COG0666 LUCA
GeneTreeiENSGT00810000125346
HOVERGENiHBG052650
KOiK20996
OMAiCQSQPCH
OrthoDBiEOG091G01NU
TreeFamiTF351641

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR008297 Notch
IPR035993 Notch-like_dom_sf
IPR022355 Notch_4
IPR000800 Notch_dom
IPR010660 Notch_NOD_dom
IPR011656 Notch_NODP_dom
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00008 EGF, 17 hits
PF07645 EGF_CA, 3 hits
PF12661 hEGF, 3 hits
PF07684 NODP, 1 hit
PF00066 Notch, 3 hits
PIRSFiPIRSF002279 Notch, 3 hits
PRINTSiPR01452 LNOTCHREPEAT
PR01987 NOTCH4
SMARTiView protein in SMART
SM00248 ANK, 6 hits
SM00181 EGF, 28 hits
SM00179 EGF_CA, 21 hits
SM00004 NL, 3 hits
SM01338 NOD, 1 hit
SM01339 NODP, 1 hit
SUPFAMiSSF48403 SSF48403, 1 hit
SSF57184 SSF57184, 5 hits
SSF90193 SSF90193, 2 hits
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 5 hits
PS00010 ASX_HYDROXYL, 11 hits
PS00022 EGF_1, 27 hits
PS01186 EGF_2, 20 hits
PS50026 EGF_3, 27 hits
PS01187 EGF_CA, 3 hits
PS50258 LNR, 3 hits

Sequencei

Sequence statusi: Complete.

A2CG28-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPQLLLLLL LPLNFPVILT RELLCGGSPE PCANGGTCLR LSRGQGICQC
60 70 80 90 100
APGFLGETCQ FPDPCRDTQL CKNGGSCQAL LPTPPSSRSP TSPLTPHFSC
110 120 130 140 150
TCPSGFTGDR CQTHLEELCP PSFCSNGGHC YVQASGRPQC SCEPGWTGEQ
160 170 180 190 200
CQLRDFCSAN PCANGGVCLA TYPQIQCRCP PGFEGHTCER DINECFLEPG
210 220 230 240 250
PCPQGTSCHN TLGSYQCLCP VGQEGPQCKL RKGACPPGSC LNGGTCQLVP
260 270 280 290 300
EGHSTFHLCL CPPGFTGLDC EMNPDDCVRH QCQNGATCLD GLDTYTCLCP
310 320 330 340 350
KTWKGWDCSE DIDECEARGP PRCRNGGTCQ NTAGSFHCVC VSGWGGAGCE
360 370 380 390 400
ENLDDCAAAT CAPGSTCIDR VGSFSCLCPP GRTGLLCHLE DMCLSQPCHV
410 420 430 440 450
NAQCSTNPLT GSTLCICQPG YSGSTCHQDL DECQMAQQGP SPCEHGGSCI
460 470 480 490 500
NTPGSFNCLC LPGYTGSRCE ADHNECLSQP CHPGSTCLDL LATFHCLCPP
510 520 530 540 550
GLEGRLCEVE VNECTSNPCL NQAACHDLLN GFQCLCLPGF TGARCEKDMD
560 570 580 590 600
ECSSTPCANG GRCRDQPGAF YCECLPGFEG PHCEKEVDEC LSDPCPVGAS
610 620 630 640 650
CLDLPGAFFC LCRPGFTGQL CEVPLCTPNM CQPGQQCQGQ EHRAPCLCPD
660 670 680 690 700
GSPGCVPAED NCPCHHGHCQ RSLCVCDEGW TGPECETELG GCISTPCAHG
710 720 730 740 750
GTCHPQPSGY NCTCPAGYMG LTCSEEVTAC HSGPCLNGGS CSIRPEGYSC
760 770 780 790 800
TCLPSHTGRH CQTAVDHCVS ASCLNGGTCV NKPGTFFCLC ATGFQGLHCE
810 820 830 840 850
EKTNPSCADS PCRNKATCQD TPRGARCLCS PGYTGSSCQT LIDLCARKPC
860 870 880 890 900
PHTARCLQSG PSFQCLCLQG WTGALCDFPL SCQKAAMSQG IEISGLCQNG
910 920 930 940 950
GLCIDTGSSY FCRCPPGFQG KLCQDNVNPC EPNPCHHGST CVPQPSGYVC
960 970 980 990 1000
QCAPGYEGQN CSKVLDACQS QPCHNHGTCT SRPGGFHCAC PPGFVGLRCE
1010 1020 1030 1040 1050
GDVDECLDRP CHPSGTAACH SLANAFYCQC LPGHTGQRCE VEMDLCQSQP
1060 1070 1080 1090 1100
CSNGGSCEIT TGPPPGFTCH CPKGFEGPTC SHKALSCGIH HCHNGGLCLP
1110 1120 1130 1140 1150
SPKPGSPPLC ACLSGFGGPD CLTPPAPPGC GPPSPCLHNG TCTETPGLGN
1160 1170 1180 1190 1200
PGFQCTCPPD SPGPRCQRPG ASGCEGRGGD GTCDAGCSGP GGDWDGGDCS
1210 1220 1230 1240 1250
LGVPDPWKGC PPHSQCWLLF RDGRCHPQCD SEECLFDGYD CEIPLTCIPA
1260 1270 1280 1290 1300
YDQYCRDHFH NGHCEKGCNN AECGWDGGDC RPEGEDSEGR PSLALLVVLR
1310 1320 1330 1340 1350
PPALDQQLLA LARVLSLTLR VGLWVRKDSE GRNMVFPYPG TRAKEELSGA
1360 1370 1380 1390 1400
RDSSSWERQA PPTQPLGKET ESLGAGFVVV MGVDLSRCGP EHPASRCPWD
1410 1420 1430 1440 1450
SGLLLRFLAA MAAVGALEPL LPGPLLAAHP QAGTRPSANQ LPWPILCSPV
1460 1470 1480 1490 1500
VGVLLLALGA LLVLQLIRRR RREHGALWLP PGFIRRPQTQ QAPHRRRPPL
1510 1520 1530 1540 1550
GEDNIGLKAL KPEAEVDEDG VAMCSGPEEG EAEETASASR CQLWPLNSGC
1560 1570 1580 1590 1600
GELPQAAMLT PPQECESEVL DVDTCGPDGV TPLMSAVFCG GVQSTTGASP
1610 1620 1630 1640 1650
QRLGLGNLEP WEPLLDRGAC PQAHTVGTGE TPLHLAARFS RPTAARRLLE
1660 1670 1680 1690 1700
AGANPNQPDR AGRTPLHTAV AADAREVCQL LLASRQTTVD ARTEDGTTPL
1710 1720 1730 1740 1750
MLAARLAVED LVEELIAARA DVGARDKRGK TALHWAAAVN NARAARSLLQ
1760 1770 1780 1790 1800
AGADKDAQDS REQTPLFLAA REGAVEVAQL LLELGAARGL RDQAGLAPGD
1810 1820 1830 1840 1850
VARQRSHWDL LTLLEGAGPT TQEARAHART TPGGGAAPRC RTLSAGARPR
1860 1870 1880 1890 1900
GGGACLQART WSVDLGARGG KVYARCRSRS GSCGGPTTRG RRFSAGSRGR
1910 1920 1930 1940 1950
RGARASQDDW PRDWVALEAC GSACSAPIPP PSLTPSPERG SPQVAWGLPV
1960
HQEIPLNSVV RNLN
Length:1,964
Mass (Da):206,702
Last modified:February 20, 2007 - v1
Checksum:i53D7F86394FC40BD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CT009767 Genomic DNA Translation: CAM18615.1
RefSeqiNP_035059.2, NM_010929.2
UniGeneiMm.173813

Genome annotation databases

EnsembliENSMUST00000015612; ENSMUSP00000015612; ENSMUSG00000015468
GeneIDi18132
KEGGimmu:18132
UCSCiuc008ccs.1 mouse

Similar proteinsi

Entry informationi

Entry nameiA2CG28_MOUSE
AccessioniPrimary (citable) accession number: A2CG28
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health