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Protein
Submitted name:

Arachidonate 15-lipoxygenase

Gene

Alox15

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cofactori

Fe cationUniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenaseUniRule annotationSAAS annotation, Oxidoreductase
LigandIronUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Arachidonate 15-lipoxygenaseImported
Gene namesi
Name:Alox15Imported
ORF Names:mCG_21185Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:87997 Alox15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1795145

Expressioni

Gene expression databases

BgeeiENSMUSG00000018924

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 115PLATInterPro annotationAdd BLAST114
Domaini115 – 663LipoxygenaseInterPro annotationAdd BLAST549

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili617 – 644Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the lipoxygenase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IKAN Eukaryota
ENOG410YN4N LUCA
HOVERGENiHBG005150
KOiK00460
OMAiLTCWKDL
OrthoDBiEOG091G04A4

Family and domain databases

InterProiView protein in InterPro
IPR000907 LipOase
IPR013819 LipOase_C
IPR036226 LipOase_C_sf
IPR020834 LipOase_CS
IPR020833 LipOase_Fe_BS
IPR001885 LipOase_mml
IPR001024 PLAT/LH2_dom
IPR036392 PLAT/LH2_dom_sf
PANTHERiPTHR11771 PTHR11771, 1 hit
PfamiView protein in Pfam
PF00305 Lipoxygenase, 1 hit
PF01477 PLAT, 1 hit
PRINTSiPR00087 LIPOXYGENASE
PR00467 MAMLPOXGNASE
SMARTiView protein in SMART
SM00308 LH2, 1 hit
SUPFAMiSSF48484 SSF48484, 1 hit
SSF49723 SSF49723, 1 hit
PROSITEiView protein in PROSITE
PS00711 LIPOXYGENASE_1, 1 hit
PS00081 LIPOXYGENASE_2, 1 hit
PS51393 LIPOXYGENASE_3, 1 hit
PS50095 PLAT, 1 hit

Sequencei

Sequence statusi: Complete.

A2CF88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGVYRIRVST GDSVYAGSNN EVYLWLIGQH GEASLGKLFR PCRNSEAEFK
60 70 80 90 100
VDVSEYLGPL LFVRVQKWHY LKEDAWFCNW ISVKGPGDQG SEYTFPCYRW
110 120 130 140 150
VQGTSILNLP EGTGCTVVED SQGLFRNHRE EELEERRSLY RWGNWKDGTI
160 170 180 190 200
LNVAATSISD LPVDQRFRED KRLEFEASQV LGTMDTVINF PKNTVTCWKS
210 220 230 240 250
LDDFNYVFKS GHTKMAERVR NSWKEDAFFG YQFLNGANPM VLKRSTCLPA
260 270 280 290 300
RLVFPPGMEK LQAQLDEELK KGTLFEADFF LLDGIKANVI LCSQQYLAAP
310 320 330 340 350
LVMLKLQPDG QLLPIAIQLE LPKTGSTPPP IFTPLDPPMD WLLAKCWVRS
360 370 380 390 400
SDLQLHELQA HLLRGHLVAE VFAVATMRCL PSVHPVFKLL VPHLLYTMEI
410 420 430 440 450
NVRARSDLIS ERGFFDKVMS TGGGGHLDLL KQAGAFLTYS SLCPPDDLAE
460 470 480 490 500
RGLLDIDTCF YAKDALQLWQ VMNRYVVGMF DLYYKTDQAV QDDYELQSWC
510 520 530 540 550
QEITEIGLQG AQDRGFPTSL QSRAQACHFI TMCIFTCTAQ HSSIHLGQLD
560 570 580 590 600
WFYWVPNAPC TMRLPPPKTK DATMEKLMAT LPNPNQSTLQ INVVWLLGRR
610 620 630 640 650
QAVMVPLGQH SEEHFPNPEA KAVLKKFREE LAALDKEIEI RNKSLDIPYE
660
YLRPSLVENS VAI
Length:663
Mass (Da):75,445
Last modified:February 20, 2007 - v1
Checksum:i0D5412B4502B5799
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU007907 Genomic DNA Translation: ABV02575.1
CH466596 Genomic DNA Translation: EDL12554.1
RefSeqiNP_033790.3, NM_009660.3
UniGeneiMm.4584

Genome annotation databases

GeneIDi11687
KEGGimmu:11687

Similar proteinsi

Entry informationi

Entry nameiA2CF88_MOUSE
AccessioniPrimary (citable) accession number: A2CF88
Entry historyiIntegrated into UniProtKB/TrEMBL: February 20, 2007
Last sequence update: February 20, 2007
Last modified: March 28, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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