A2CDU0 (ACSF_PROM3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase
Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase
EC=1.14.13.81

Gene names

Name:	acsF
Ordered Locus Names:	P9303_29201

Organism

Prochlorococcus marinus (strain MIT 9303) [Complete proteome] [HAMAP]

Taxonomic identifier

59922 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	349 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) By similarity. HAMAP MF_01840
Catalytic activity	Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. HAMAP MF_01840 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. HAMAP MF_01840 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. HAMAP MF_01840
Cofactor	Iron By similarity. HAMAP MF_01840
Pathway	Porphyrin biosynthesis; chlorophyll biosynthesis (light-independent). HAMAP MF_01840
Sequence similarities	Belongs to the AcsF family.

Ontologies

Keywords
Biological process	Chlorophyll biosynthesis Photosynthesis
Ligand	Iron Metal-binding NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW photosynthesis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activity Inferred from electronic annotation. Source: EC transition metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 349	349	Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase HAMAP MF_01840		PRO_1000188411

Sequences

	Sequence		Length	Mass (Da)
	A2CDU0 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: E5D3215D70CFE379	FASTA	349	40,426
	10 20 30 40 50 60 MTATTATAPA MRGGGRNELP PHLDDNLLTP RFYTTEFDKA AKTDLDIARK DFEAMFKEME 70 80 90 100 110 120 ADYNLKHFDR KASLERLADL SPEDKAIYES YLVRSVVSEF SGFLLFKEIS NRFKKAGRQE 130 140 150 160 170 180 LGQFFTFLAR DEARHAGFLG RALKAEGINV DLPNLGNKRA PTFFPLSWVL YSLYLSEKIG 190 200 210 220 230 240 YWRYILINRH LNDNPEKVCA PLFDFFEPWC QDENRHGDCI NLMMRCWPGM TKGFRGKLLS 250 260 270 280 290 300 RFFLWSVFLT HTLTVCERGD FYGLLGIDPV LFDEEVIVQT NNTSRNAFPW VYNFDDGKFL 310 320 330 340 EMRMQILKAF RNWRESSGLA KPVALSKFVS LILRQFALPM QKTNAVRYG

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MIT 9303.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000554 Genomic DNA. Translation: ABM79650.1.
RefSeq	YP_001018915.1. NC_008820.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	A2CDU0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	4776886.
GenomeReviews	Gene locus P9303_29201 in contig CP000554_GR.
KEGG	pmf:P9303_29201.
PATRIC	23003387. VBIProMar17757_2977.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	NOG10633.
HOGENOM	HBG284843.
OMA	NRHGDIF.
PhylomeDB	A2CDU0.
ProtClustDB	PRK13654.
Family and domain databases
HAMAP	MF_01840. AcsF. [Tree]
InterPro	IPR008434. AcsF. IPR009078. Ferritin/RR-like. IPR003251. Rubrerythrin. [Graphical view]
KO	K04035.
Pfam	PF02915. Rubrerythrin. 1 hit. [Graphical view]
SUPFAM	SSF47240. Ferritin/RR_like. 1 hit.
TIGRFAMs	TIGR02029. AcsF. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACSF_PROM3

Accession

Primary (citable) accession number: A2CDU0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 20, 2007
Last modified:	December 14, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program