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A2CDR0

- GCSP_PROM3

UniProt

A2CDR0 - GCSP_PROM3

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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. lyase activity Source: InterPro
  3. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59922:GH54-3000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:P9303_28901
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Glycine dehydrogenase (decarboxylating)PRO_1000147968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei721 – 7211N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi59922.P9303_28901.

Structurei

3D structure databases

ProteinModelPortaliA2CDR0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A2CDR0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTLLEQRAVE ASSIQSSPFL VRHIGPSFED QQQMLLELGH RDLQSFVAAV
60 70 80 90 100
VPPDILETTA PTSSLPEGCG EVQAMEELRL IAAANRVRRS LIGLGYYGTA
110 120 130 140 150
TPALIQRQVL ENPAWYTAYT PYQAEISQGR LEALFNFQTL ISELTGLPIA
160 170 180 190 200
NASLLDEGTA AAEAMSLSFA ICKRPQAHRF LVDAEVLPQT LAVLRTRAEP
210 220 230 240 250
LGIHLEVAEP MTFQFDAEVF GVLLQLPGRS GRLWDPTTSI QAAHEVGALA
260 270 280 290 300
TVAIDPLAQV LIAPVAEFGA DIAVGSVQRF GVPMAFGGPH AAFFATLEIF
310 320 330 340 350
KRQVPGRLVG QSVDAEGQPA LRLALQTREQ HIRRDKATSN ICTAQVLLAV
360 370 380 390 400
MASFYAVHHG PDGLAAIARR VLLLRAQLER GLHQLGYPVQ SIARFDTIEV
410 420 430 440 450
ICREAPAVHQ AAALAGFNLR VLPLGVAPEA AHGFGISFDE LSTDQELKSI
460 470 480 490 500
LQILAEAAGQ PVPVLEDLGN PHLEELVGLP LRQRPWLQQQ VFHRYRSETE
510 520 530 540 550
LLRYLQRLVG RDLSLVHGMI PLGSCTMKLN AAAELIPISW REFAALHPFA
560 570 580 590 600
PQDQCHGYQR LVQDLEHWFA EITGFAGVSL QPNAGSQGEL AGLLVIRAWH
610 620 630 640 650
HSRGEQQRDV CLIPTSAHGT NPATCVMAGL RVVPVACDAE GNVDLNDLAS
660 670 680 690 700
KAEAHAPQLA ALMVTYPSTH GVFEPQIREI CELVHGHGGQ VYLDGANLNA
710 720 730 740 750
QIGFCRPGTY GADVCHINLH KTFCIPHGGG GPGVGPIAVA AHLMPFLPGH
760 770 780 790 800
PLAACGGEQG IGAISAAPWG SAGILPISWM YLRMMGAEGL RQASAVALLS
810 820 830 840 850
ANYLAHRLHP HYPVLFRGQA GLVAHECILD LRPLKRSAGL EVDDIAKRLM
860 870 880 890 900
DYGFHAPTVS WPVAGTVMVE PTESESLEEL NRFCDAMIAI REETAAIESG
910 920 930 940 950
QIDPQNNPLR RAPHTLAAVT AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS
960 970 980
RIDNAYGDRN LLCSCPSVEE LADNSVLKPP LV
Length:982
Mass (Da):106,280
Last modified:February 20, 2007 - v1
Checksum:iFD1E911438C2C33F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM79620.1.
RefSeqiWP_011827461.1. NC_008820.1.
YP_001018885.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM79620; ABM79620; P9303_28901.
GeneIDi4778971.
KEGGipmf:P9303_28901.
PATRICi23003323. VBIProMar17757_2945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM79620.1 .
RefSeqi WP_011827461.1. NC_008820.1.
YP_001018885.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2CDR0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_28901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM79620 ; ABM79620 ; P9303_28901 .
GeneIDi 4778971.
KEGGi pmf:P9303_28901.
PATRICi 23003323. VBIProMar17757_2945.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PMAR59922:GH54-3000-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiGCSP_PROM3
AccessioniPrimary (citable) accession number: A2CDR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 20, 2007
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3