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A2CDR0

- GCSP_PROM3

UniProt

A2CDR0 - GCSP_PROM3

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, P9303_28901
Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. lyase activity Source: InterPro
  3. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59922:GH54-3000-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:P9303_28901
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 982982Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000147968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei721 – 7211N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi59922.P9303_28901.

Structurei

3D structure databases

ProteinModelPortaliA2CDR0.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

A2CDR0-1 [UniParc]FASTAAdd to Basket

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MTLLEQRAVE ASSIQSSPFL VRHIGPSFED QQQMLLELGH RDLQSFVAAV    50
VPPDILETTA PTSSLPEGCG EVQAMEELRL IAAANRVRRS LIGLGYYGTA 100
TPALIQRQVL ENPAWYTAYT PYQAEISQGR LEALFNFQTL ISELTGLPIA 150
NASLLDEGTA AAEAMSLSFA ICKRPQAHRF LVDAEVLPQT LAVLRTRAEP 200
LGIHLEVAEP MTFQFDAEVF GVLLQLPGRS GRLWDPTTSI QAAHEVGALA 250
TVAIDPLAQV LIAPVAEFGA DIAVGSVQRF GVPMAFGGPH AAFFATLEIF 300
KRQVPGRLVG QSVDAEGQPA LRLALQTREQ HIRRDKATSN ICTAQVLLAV 350
MASFYAVHHG PDGLAAIARR VLLLRAQLER GLHQLGYPVQ SIARFDTIEV 400
ICREAPAVHQ AAALAGFNLR VLPLGVAPEA AHGFGISFDE LSTDQELKSI 450
LQILAEAAGQ PVPVLEDLGN PHLEELVGLP LRQRPWLQQQ VFHRYRSETE 500
LLRYLQRLVG RDLSLVHGMI PLGSCTMKLN AAAELIPISW REFAALHPFA 550
PQDQCHGYQR LVQDLEHWFA EITGFAGVSL QPNAGSQGEL AGLLVIRAWH 600
HSRGEQQRDV CLIPTSAHGT NPATCVMAGL RVVPVACDAE GNVDLNDLAS 650
KAEAHAPQLA ALMVTYPSTH GVFEPQIREI CELVHGHGGQ VYLDGANLNA 700
QIGFCRPGTY GADVCHINLH KTFCIPHGGG GPGVGPIAVA AHLMPFLPGH 750
PLAACGGEQG IGAISAAPWG SAGILPISWM YLRMMGAEGL RQASAVALLS 800
ANYLAHRLHP HYPVLFRGQA GLVAHECILD LRPLKRSAGL EVDDIAKRLM 850
DYGFHAPTVS WPVAGTVMVE PTESESLEEL NRFCDAMIAI REETAAIESG 900
QIDPQNNPLR RAPHTLAAVT AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS 950
RIDNAYGDRN LLCSCPSVEE LADNSVLKPP LV 982
Length:982
Mass (Da):106,280
Last modified:February 20, 2007 - v1
Checksum:iFD1E911438C2C33F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM79620.1.
RefSeqiYP_001018885.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM79620; ABM79620; P9303_28901.
GeneIDi4778971.
KEGGipmf:P9303_28901.
PATRICi23003323. VBIProMar17757_2945.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM79620.1 .
RefSeqi YP_001018885.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2CDR0.
ModBasei Search...

Protein-protein interaction databases

STRINGi 59922.P9303_28901.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM79620 ; ABM79620 ; P9303_28901 .
GeneIDi 4778971.
KEGGi pmf:P9303_28901.
PATRICi 23003323. VBIProMar17757_2945.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PMAR59922:GH54-3000-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiGCSP_PROM3
AccessioniPrimary (citable) accession number: A2CDR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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