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A2CDR0 (GCSP_PROM3) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:P9303_28901
OrganismProchlorococcus marinus (strain MIT 9303) [Complete proteome] [HAMAP]
Taxonomic identifier59922 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus

Protein attributes

Sequence length982 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 982982Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000147968

Amino acid modifications

Modified residue7211N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
A2CDR0 [UniParc].

Last modified February 20, 2007. Version 1.
Checksum: FD1E911438C2C33F

FASTA982106,280
        10         20         30         40         50         60 
MTLLEQRAVE ASSIQSSPFL VRHIGPSFED QQQMLLELGH RDLQSFVAAV VPPDILETTA 

        70         80         90        100        110        120 
PTSSLPEGCG EVQAMEELRL IAAANRVRRS LIGLGYYGTA TPALIQRQVL ENPAWYTAYT 

       130        140        150        160        170        180 
PYQAEISQGR LEALFNFQTL ISELTGLPIA NASLLDEGTA AAEAMSLSFA ICKRPQAHRF 

       190        200        210        220        230        240 
LVDAEVLPQT LAVLRTRAEP LGIHLEVAEP MTFQFDAEVF GVLLQLPGRS GRLWDPTTSI 

       250        260        270        280        290        300 
QAAHEVGALA TVAIDPLAQV LIAPVAEFGA DIAVGSVQRF GVPMAFGGPH AAFFATLEIF 

       310        320        330        340        350        360 
KRQVPGRLVG QSVDAEGQPA LRLALQTREQ HIRRDKATSN ICTAQVLLAV MASFYAVHHG 

       370        380        390        400        410        420 
PDGLAAIARR VLLLRAQLER GLHQLGYPVQ SIARFDTIEV ICREAPAVHQ AAALAGFNLR 

       430        440        450        460        470        480 
VLPLGVAPEA AHGFGISFDE LSTDQELKSI LQILAEAAGQ PVPVLEDLGN PHLEELVGLP 

       490        500        510        520        530        540 
LRQRPWLQQQ VFHRYRSETE LLRYLQRLVG RDLSLVHGMI PLGSCTMKLN AAAELIPISW 

       550        560        570        580        590        600 
REFAALHPFA PQDQCHGYQR LVQDLEHWFA EITGFAGVSL QPNAGSQGEL AGLLVIRAWH 

       610        620        630        640        650        660 
HSRGEQQRDV CLIPTSAHGT NPATCVMAGL RVVPVACDAE GNVDLNDLAS KAEAHAPQLA 

       670        680        690        700        710        720 
ALMVTYPSTH GVFEPQIREI CELVHGHGGQ VYLDGANLNA QIGFCRPGTY GADVCHINLH 

       730        740        750        760        770        780 
KTFCIPHGGG GPGVGPIAVA AHLMPFLPGH PLAACGGEQG IGAISAAPWG SAGILPISWM 

       790        800        810        820        830        840 
YLRMMGAEGL RQASAVALLS ANYLAHRLHP HYPVLFRGQA GLVAHECILD LRPLKRSAGL 

       850        860        870        880        890        900 
EVDDIAKRLM DYGFHAPTVS WPVAGTVMVE PTESESLEEL NRFCDAMIAI REETAAIESG 

       910        920        930        940        950        960 
QIDPQNNPLR RAPHTLAAVT AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS RIDNAYGDRN 

       970        980 
LLCSCPSVEE LADNSVLKPP LV 

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References

[1]"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus."
Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W.
PLoS Genet. 3:2515-2528(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MIT 9303.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000554 Genomic DNA. Translation: ABM79620.1.
RefSeqYP_001018885.1. NC_008820.1.

3D structure databases

ProteinModelPortalA2CDR0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING59922.P9303_28901.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABM79620; ABM79620; P9303_28901.
GeneID4778971.
KEGGpmf:P9303_28901.
PATRIC23003323. VBIProMar17757_2945.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycPMAR59922:GH54-3000-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF01212. Beta_elim_lyase. 1 hit.
PF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PROM3
AccessionPrimary (citable) accession number: A2CDR0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 20, 2007
Last modified: February 19, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families