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A2CDR0

- GCSP_PROM3

UniProt

A2CDR0 - GCSP_PROM3

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 60 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. lyase activity Source: InterPro
    3. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPMAR59922:GH54-3000-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:P9303_28901
    OrganismiProchlorococcus marinus (strain MIT 9303)
    Taxonomic identifieri59922 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002274: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 982982Glycine dehydrogenase (decarboxylating)PRO_1000147968Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei721 – 7211N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi59922.P9303_28901.

    Structurei

    3D structure databases

    ProteinModelPortaliA2CDR0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF01212. Beta_elim_lyase. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2CDR0-1 [UniParc]FASTAAdd to Basket

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    MTLLEQRAVE ASSIQSSPFL VRHIGPSFED QQQMLLELGH RDLQSFVAAV    50
    VPPDILETTA PTSSLPEGCG EVQAMEELRL IAAANRVRRS LIGLGYYGTA 100
    TPALIQRQVL ENPAWYTAYT PYQAEISQGR LEALFNFQTL ISELTGLPIA 150
    NASLLDEGTA AAEAMSLSFA ICKRPQAHRF LVDAEVLPQT LAVLRTRAEP 200
    LGIHLEVAEP MTFQFDAEVF GVLLQLPGRS GRLWDPTTSI QAAHEVGALA 250
    TVAIDPLAQV LIAPVAEFGA DIAVGSVQRF GVPMAFGGPH AAFFATLEIF 300
    KRQVPGRLVG QSVDAEGQPA LRLALQTREQ HIRRDKATSN ICTAQVLLAV 350
    MASFYAVHHG PDGLAAIARR VLLLRAQLER GLHQLGYPVQ SIARFDTIEV 400
    ICREAPAVHQ AAALAGFNLR VLPLGVAPEA AHGFGISFDE LSTDQELKSI 450
    LQILAEAAGQ PVPVLEDLGN PHLEELVGLP LRQRPWLQQQ VFHRYRSETE 500
    LLRYLQRLVG RDLSLVHGMI PLGSCTMKLN AAAELIPISW REFAALHPFA 550
    PQDQCHGYQR LVQDLEHWFA EITGFAGVSL QPNAGSQGEL AGLLVIRAWH 600
    HSRGEQQRDV CLIPTSAHGT NPATCVMAGL RVVPVACDAE GNVDLNDLAS 650
    KAEAHAPQLA ALMVTYPSTH GVFEPQIREI CELVHGHGGQ VYLDGANLNA 700
    QIGFCRPGTY GADVCHINLH KTFCIPHGGG GPGVGPIAVA AHLMPFLPGH 750
    PLAACGGEQG IGAISAAPWG SAGILPISWM YLRMMGAEGL RQASAVALLS 800
    ANYLAHRLHP HYPVLFRGQA GLVAHECILD LRPLKRSAGL EVDDIAKRLM 850
    DYGFHAPTVS WPVAGTVMVE PTESESLEEL NRFCDAMIAI REETAAIESG 900
    QIDPQNNPLR RAPHTLAAVT AEVWDRPYSR AEAAFPLAEQ RQSKFWPAVS 950
    RIDNAYGDRN LLCSCPSVEE LADNSVLKPP LV 982
    Length:982
    Mass (Da):106,280
    Last modified:February 20, 2007 - v1
    Checksum:iFD1E911438C2C33F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM79620.1.
    RefSeqiYP_001018885.1. NC_008820.1.

    Genome annotation databases

    EnsemblBacteriaiABM79620; ABM79620; P9303_28901.
    GeneIDi4778971.
    KEGGipmf:P9303_28901.
    PATRICi23003323. VBIProMar17757_2945.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM79620.1 .
    RefSeqi YP_001018885.1. NC_008820.1.

    3D structure databases

    ProteinModelPortali A2CDR0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59922.P9303_28901.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM79620 ; ABM79620 ; P9303_28901 .
    GeneIDi 4778971.
    KEGGi pmf:P9303_28901.
    PATRICi 23003323. VBIProMar17757_2945.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PMAR59922:GH54-3000-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR001597. ArAA_b-elim_lyase/Thr_aldolase.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF01212. Beta_elim_lyase. 1 hit.
    PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9303.

    Entry informationi

    Entry nameiGCSP_PROM3
    AccessioniPrimary (citable) accession number: A2CDR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 60 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3