Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2CDK1

- SPEA_PROM3

UniProt

A2CDK1 - SPEA_PROM3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Biosynthetic arginine decarboxylase

Gene

speA

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation
  • pyridoxal 5'-phosphateUniRule annotation

Pathwayi

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMAR59922:GH54-2941-MONOMER.
UniPathwayiUPA00186; UER00284.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
Short name:
ADCUniRule annotation
Gene namesi
Name:speAUniRule annotation
Ordered Locus Names:P9303_28311
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Biosynthetic arginine decarboxylasePRO_1000024259Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei109 – 1091N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi59922.P9303_28311.

Structurei

3D structure databases

ProteinModelPortaliA2CDK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni291 – 30111Substrate-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2CDK1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAADPSQGN KSWTVADSAA LYGLDRWGEP YFTANANGHV QVKPRGDQGS
60 70 80 90 100
CLDLVELVEE LKSRNLNLPL LIRFDDILED RLEKLHSAFE QAISKYGYAG
110 120 130 140 150
RYQGVFPVKC NQQRHVVEQL VESGRHWHFG LEAGSKAELL IALSLVNDPE
160 170 180 190 200
ALLICNGYKD QRYIETAILA RRLGRQPVVV IEQPDEVERI IRSSQELGAA
210 220 230 240 250
PFIGVRAKLT TRSTGHWSSS VGEKAKFGLS FPDLLSTVEA LRQADLLSDL
260 270 280 290 300
RLLHFHIGSQ INDIAVLKDA IQEAGQIYVE LTKLGAPMGY LDVGGGLGVD
310 320 330 340 350
YDGSRSASAA STNYSLQNYA NDVVATVREC CKPHGITLPI LVSESGRAIA
360 370 380 390 400
SHFSILVFDV LGTGTVPGAV PNQTGEEPLT IHNLRETLAG VMATQKGAAS
410 420 430 440 450
EISRLQEAWN DAVKFKDDAL AAFRLGYISL TERALAEQLT WACAEAIMGQ
460 470 480 490 500
LPCHETIPDD LQGLRAVLAG TYYANLSIFR SAPDTWAIEQ LFPLMPIHRL
510 520 530 540 550
KEEPTQLGHF ADLTCDSDGK LDRFIGNGQT KTLLELHNLR QNEAYMIGMF
560 570 580 590 600
LAGAYQEVMG NLHNLFGSTN AVHIRMTTGG GYQIDHVVRG NTNSEVLEAM
610 620 630 640
EHNPEILLER LRLASELAIQ RGELKINDVR RLMDHLETSL RQTTYLQG
Length:648
Mass (Da):71,351
Last modified:February 20, 2007 - v1
Checksum:i648B16E4961C51D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM79561.1.
RefSeqiYP_001018826.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM79561; ABM79561; P9303_28311.
GeneIDi4776972.
KEGGipmf:P9303_28311.
PATRICi23003209. VBIProMar17757_2888.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000554 Genomic DNA. Translation: ABM79561.1 .
RefSeqi YP_001018826.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2CDK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_28311.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM79561 ; ABM79561 ; P9303_28311 .
GeneIDi 4776972.
KEGGi pmf:P9303_28311.
PATRICi 23003209. VBIProMar17757_2888.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

UniPathwayi UPA00186 ; UER00284 .
BioCyci PMAR59922:GH54-2941-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiSPEA_PROM3
AccessioniPrimary (citable) accession number: A2CDK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3