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A2CCP6

- NDHK_PROM3

UniProt

A2CCP6 - NDHK_PROM3

Protein

NAD(P)H-quinone oxidoreductase subunit K

Gene

ndhK

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration.UniRule annotation

    Catalytic activityi

    NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

    Cofactori

    Binds 1 4Fe-4S cluster.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi61 – 611Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi125 – 1251Iron-sulfur (4Fe-4S)UniRule annotation
    Metal bindingi156 – 1561Iron-sulfur (4Fe-4S)UniRule annotation

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. iron ion binding Source: UniProtKB-HAMAP
    3. NADH dehydrogenase (ubiquinone) activity Source: InterPro
    4. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. photosynthesis, light reaction Source: UniProtKB-HAMAP
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    4Fe-4S, Iron, Iron-sulfur, Metal-binding, NAD, NADP, Plastoquinone

    Enzyme and pathway databases

    BioCyciPMAR59922:GH54-2631-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD(P)H-quinone oxidoreductase subunit KUniRule annotation (EC:1.6.5.-UniRule annotation)
    Alternative name(s):
    NAD(P)H dehydrogenase I subunit KUniRule annotation
    NDH-1 subunit KUniRule annotation
    Short name:
    NDH-KUniRule annotation
    Gene namesi
    Name:ndhKUniRule annotation
    Ordered Locus Names:P9303_25251
    OrganismiProchlorococcus marinus (strain MIT 9303)
    Taxonomic identifieri59922 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002274: Chromosome

    Subcellular locationi

    Cellular thylakoid membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation

    GO - Cellular componenti

    1. thylakoid membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Thylakoid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 250250NAD(P)H-quinone oxidoreductase subunit KPRO_0000358453Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions.UniRule annotation

    Protein-protein interaction databases

    STRINGi59922.P9303_25251.

    Structurei

    3D structure databases

    ProteinModelPortaliA2CCP6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I 20 kDa subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0377.
    HOGENOMiHOG000228249.
    KOiK05582.
    OMAiKKVGNES.
    OrthoDBiEOG62K20C.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    HAMAPiMF_01356. NDH1_NuoB.
    InterProiIPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view]
    PfamiPF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01957. nuoB_fam. 1 hit.
    PROSITEiPS01150. COMPLEX1_20K. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2CCP6-1 [UniParc]FASTAAdd to Basket

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    MSVTPSIDAV RDLRAASCGP VGAPSVTSEL SENIILTSLD DLHNWARLSS    50
    LWPLLYGTAC CFIEFAALIG SRFDFDRFGL VPRSSPRQAD LLIVAGTVTM 100
    KMAPALVRLY EQMPEPKYVI AMGACTITGG MFSADSTTAV RGVDKLIPVD 150
    LYLPGCPPRP EAIFDAVIKL RKKVGDESVS ERIKIAQTHR YFTVPHQMKR 200
    VEPIVTGAYL SADTQKAALS PGAGLPMAAE LNTSEIDASP ASQPSSTYES 250
    Length:250
    Mass (Da):26,879
    Last modified:February 20, 2007 - v1
    Checksum:i37A2BD06379B2017
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM79256.1.
    RefSeqiWP_011827102.1. NC_008820.1.
    YP_001018521.1. NC_008820.1.

    Genome annotation databases

    EnsemblBacteriaiABM79256; ABM79256; P9303_25251.
    GeneIDi4778323.
    KEGGipmf:P9303_25251.
    PATRICi23002609. VBIProMar17757_2590.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM79256.1 .
    RefSeqi WP_011827102.1. NC_008820.1.
    YP_001018521.1. NC_008820.1.

    3D structure databases

    ProteinModelPortali A2CCP6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59922.P9303_25251.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM79256 ; ABM79256 ; P9303_25251 .
    GeneIDi 4778323.
    KEGGi pmf:P9303_25251.
    PATRICi 23002609. VBIProMar17757_2590.

    Phylogenomic databases

    eggNOGi COG0377.
    HOGENOMi HOG000228249.
    KOi K05582.
    OMAi KKVGNES.
    OrthoDBi EOG62K20C.

    Enzyme and pathway databases

    BioCyci PMAR59922:GH54-2631-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    HAMAPi MF_01356. NDH1_NuoB.
    InterProi IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    IPR006138. NADH_UQ_OxRdtase_20Kd_su.
    [Graphical view ]
    Pfami PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01957. nuoB_fam. 1 hit.
    PROSITEi PS01150. COMPLEX1_20K. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9303.

    Entry informationi

    Entry nameiNDHK_PROM3
    AccessioniPrimary (citable) accession number: A2CCP6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3