SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2CCK6

- PUR9_PROM3

UniProt

A2CCK6 - PUR9_PROM3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Bifunctional purine biosynthesis protein PurH

Gene
purH, P9303_24851
Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciPMAR59922:GH54-2590-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurH
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC:2.1.2.3)
Alternative name(s):
AICAR transformylase
IMP cyclohydrolase (EC:3.5.4.10)
Alternative name(s):
ATIC
IMP synthase
Inosinicase
Gene namesi
Name:purH
Ordered Locus Names:P9303_24851
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Bifunctional purine biosynthesis protein PurHUniRule annotationPRO_1000018927Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59922.P9303_24851.

Structurei

3D structure databases

ProteinModelPortaliA2CCK6.

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A2CCK6-1 [UniParc]FASTAAdd to Basket

« Hide

MAPIALLSVS NKHGIVSLAE SLHRMHGFQL LSSGGTAKVL EDAGLPVTRV    50
AEHTGAAEIL GGRVKTLHPR VHGGILAMRG DPDHEVDLEQ HQIPPIDVVV 100
VNLYPFRETV ANPQVSWETA IENIDIGGPA MVRAAAKNHA HVAVLTRPDQ 150
YDRFLVALSD GVDGQLRREL ALEAFEHTAA YDVAISHWMG VRLSEQASQW 200
LEAIPLRQRL RYGENPHQQA AWYSAPKQGW GGAIQLQGKE LSTNNLLDLE 250
AALATVREFG YGTDGAHQAV QDAAVVVKHT NPCGVAIGTG VASALSRALD 300
ADRVSAFGGI VALNGLVDAT TARELTSLFL ECVVAPGFEP EAREILASKA 350
NLRLLELAPG AVDAAGRDHI RTILGGVLVQ DQDDQLIDPT SWTVASKRAP 400
TAEENDDLTF AWRLVRHVRS NAIVVARAGQ SLGVGAGQMN RVGSARLALE 450
AAGDQARGAV LASDGFFPFD DTVRLAANHG IRAVIQPGGS KRDADSIAVC 500
DEFGLAMVLT GKRHFLH 517
Length:517
Mass (Da):55,150
Last modified:February 20, 2007 - v1
Checksum:i8DD264EBBDE007D3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM79216.1.
RefSeqiYP_001018481.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM79216; ABM79216; P9303_24851.
GeneIDi4776758.
KEGGipmf:P9303_24851.
PATRICi23002519. VBIProMar17757_2546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM79216.1 .
RefSeqi YP_001018481.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2CCK6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_24851.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM79216 ; ABM79216 ; P9303_24851 .
GeneIDi 4776758.
KEGGi pmf:P9303_24851.
PATRICi 23002519. VBIProMar17757_2546.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci PMAR59922:GH54-2590-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiPUR9_PROM3
AccessioniPrimary (citable) accession number: A2CCK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi