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A2CCG0

- TRMB_PROM3

UniProt

A2CCG0 - TRMB_PROM3

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351S-adenosyl-L-methionineUniRule annotation
    Binding sitei60 – 601S-adenosyl-L-methionineUniRule annotation
    Binding sitei87 – 871S-adenosyl-L-methionineUniRule annotation
    Active sitei113 – 1131By similarity
    Binding sitei113 – 1131S-adenosyl-L-methionineUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei149 – 1491SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciPMAR59922:GH54-2544-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:P9303_24391
    OrganismiProchlorococcus marinus (strain MIT 9303)
    Taxonomic identifieri59922 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002274: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 236236tRNA (guanine-N(7)-)-methyltransferasePRO_0000288199Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59922.P9303_24391.

    Structurei

    3D structure databases

    ProteinModelPortaliA2CCG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000237936.
    KOiK03439.
    OMAiRVTIQFP.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A2CCG0-1 [UniParc]FASTAAdd to Basket

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    MRQHVNPLSR FFQLPRPLPS PEEMFAQSSR PLHLDIGCAR GGFLLGLAPL    50
    QPEWNHVGVE IRHPLVLSAE RDRQELKLDN LRFLFCNVNV SLEEWLDALP 100
    RDQLQWVSIQ FPDPWFKRRH QKRRVLQPSL LIALATALQP GRELFIQSDV 150
    LSVIEPMVML IEQSNCFKRP GDDFHPWQRT NPMPVPTERE RYVLDQGLQV 200
    YRRLYQRNDQ QAPELSNLEA LWQQVDNPSE EEHSDC 236
    Length:236
    Mass (Da):27,713
    Last modified:February 20, 2007 - v1
    Checksum:i6737525D226162A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM79170.1.
    RefSeqiYP_001018435.1. NC_008820.1.

    Genome annotation databases

    EnsemblBacteriaiABM79170; ABM79170; P9303_24391.
    GeneIDi4778756.
    KEGGipmf:P9303_24391.
    PATRICi23002429. VBIProMar17757_2502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM79170.1 .
    RefSeqi YP_001018435.1. NC_008820.1.

    3D structure databases

    ProteinModelPortali A2CCG0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59922.P9303_24391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM79170 ; ABM79170 ; P9303_24391 .
    GeneIDi 4778756.
    KEGGi pmf:P9303_24391.
    PATRICi 23002429. VBIProMar17757_2502.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000237936.
    KOi K03439.
    OMAi RVTIQFP.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci PMAR59922:GH54-2544-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9303.

    Entry informationi

    Entry nameiTRMB_PROM3
    AccessioniPrimary (citable) accession number: A2CCG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3