Reviewed, UniProtKB/Swiss-Prot A2CAX3 (COMB_PROM3)

Names and origin

Protein names

Recommended name:
    Probable 2-phosphosulfolactate phosphatase
    EC=3.1.3.71

Gene names

Name:	comB
Ordered Locus Names:	P9303_18911

Organism

Prochlorococcus marinus (strain MIT 9303) [Complete proteome] [HAMAP]

Taxonomic identifier

59922 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Prochlorophytes › Prochlorococcaceae › Prochlorococcus

Protein attributes

Sequence length	243 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	(2R)-2-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate. HAMAP MF_00490
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the comB family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme M biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	2-phosphosulfolactate phosphatase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 243	243	Probable 2-phosphosulfolactate phosphatase HAMAP MF_00490		PRO_1000014467

Sequences

	Sequence		Length	Mass (Da)
	A2CAX3-1 [UniParc]. Last modified February 20, 2007. Version 1. Checksum: AC442CE48E71CDE3	FASTA	243	26,204
	10 20 30 40 50 60 MQLAYFHVAA DVPQGAEPDA AVVIDVLRAT TTIAWALNNG AEAVETFADL DQLRQSAAQW 70 80 90 100 110 120 PESSRLMLGE RGGQRIEGFD LGNSPVAVVP EQVAGKRLFM STTNGTRSLQ RVRGVQRLFT 130 140 150 160 170 180 LALPNRRAVA DHLLMDPPEQ LWIVGSGWEG AYSLEDSLAA GALADLLLNA AADEACVVND 190 200 210 220 230 240 ELTAALALWQ QWKHDPEACL RQASHGQRLI GLGDHDADFR CCAELDRLSV VPVQVKPGVL CAS

References

[1]

"Patterns and implications of gene gain and loss in the evolution of Prochlorococcus." Kettler G.C., Martiny A.C., Huang K., Zucker J., Coleman M.L., Rodrigue S., Chen F., Lapidus A., Ferriera S., Johnson J., Steglich C., Church G.M., Richardson P., Chisholm S.W. PLoS Genet. 3:2515-2528(2007) [PubMed: 18159947] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000554 Genomic DNA. Translation: ABM78633.1.
RefSeq	YP_001017898.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	4777960.
GenomeReviews	Gene locus P9303_18911 in contig CP000554_GR.
KEGG	pmf:P9303_18911.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A2CAX3. ATTTIAW.
Family and domain databases
HAMAP	MF_00490. [Tree]
InterPro	IPR005238. 2-PSlactate_phosphatase. [Graphical view]
Gene3D	G3DSA:3.90.1560.10. 2-PSlactate_phosphatase. 1 hit.
Pfam	PF04029. 2-ph_phosp. 1 hit. [Graphical view]
TIGRFAMs	TIGR00298. 2-ph_phosphatase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COMB_PROM3

Accession

Primary (citable) accession number: A2CAX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	February 20, 2007
Last modified:	May 5, 2009
This is version 13 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)