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A2CAH8

- HIS4_PROM3

UniProt

A2CAH8 - HIS4_PROM3

Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (20 Feb 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei8 – 81Proton acceptorUniRule annotation
    Active sitei129 – 1291Proton donorUniRule annotation

    GO - Molecular functioni

    1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Enzyme and pathway databases

    BioCyciPMAR59922:GH54-1840-MONOMER.
    UniPathwayiUPA00031; UER00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
    Alternative name(s):
    Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
    Gene namesi
    Name:hisAUniRule annotation
    Ordered Locus Names:P9303_17461
    OrganismiProchlorococcus marinus (strain MIT 9303)
    Taxonomic identifieri59922 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
    ProteomesiUP000002274: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2552551-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_0000290509Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi59922.P9303_17461.

    Structurei

    3D structure databases

    ProteinModelPortaliA2CAH8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HisA/HisF family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0106.
    HOGENOMiHOG000224614.
    KOiK01814.
    OMAiQRDYGSD.
    OrthoDBiEOG6H1Q3W.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01014. HisA.
    InterProiIPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00977. His_biosynth. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR00007. TIGR00007. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A2CAH8-1 [UniParc]FASTAAdd to Basket

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    MEIIPAIDLL DSACVRLHQG DYAKVTRFSE DPVAQALSWQ KQGATRLHLV    50
    DLDGAKSGEP VNDSCVRAIT SALNIPVQLG GGVRTLERAE ELLAYGLEQV 100
    ILGTVAIEQP QLVKQLAQRN PGRIIVGIDA KNGKVATRGW ISQSEVNATD 150
    LAADFNAAGI AAIISTDIAT DGTLEGPNLE SLRAMANASS VPLIASGGVG 200
    CMADLLSLLA LEPYGVSGVI VGRALYDGKV DLKEAIRAIG DGRLQDPPSS 250
    KPLMA 255
    Length:255
    Mass (Da):26,672
    Last modified:February 20, 2007 - v1
    Checksum:iAE170466A89634DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM78488.1.
    RefSeqiWP_011826375.1. NC_008820.1.
    YP_001017753.1. NC_008820.1.

    Genome annotation databases

    EnsemblBacteriaiABM78488; ABM78488; P9303_17461.
    GeneIDi4778115.
    KEGGipmf:P9303_17461.
    PATRICi23000976. VBIProMar17757_1798.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000554 Genomic DNA. Translation: ABM78488.1 .
    RefSeqi WP_011826375.1. NC_008820.1.
    YP_001017753.1. NC_008820.1.

    3D structure databases

    ProteinModelPortali A2CAH8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 59922.P9303_17461.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABM78488 ; ABM78488 ; P9303_17461 .
    GeneIDi 4778115.
    KEGGi pmf:P9303_17461.
    PATRICi 23000976. VBIProMar17757_1798.

    Phylogenomic databases

    eggNOGi COG0106.
    HOGENOMi HOG000224614.
    KOi K01814.
    OMAi QRDYGSD.
    OrthoDBi EOG6H1Q3W.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00009 .
    BioCyci PMAR59922:GH54-1840-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01014. HisA.
    InterProi IPR013785. Aldolase_TIM.
    IPR006062. His_biosynth.
    IPR006063. HisA.
    IPR023016. Isoase_HisA.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00977. His_biosynth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR00007. TIGR00007. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MIT 9303.

    Entry informationi

    Entry nameiHIS4_PROM3
    AccessioniPrimary (citable) accession number: A2CAH8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 12, 2007
    Last sequence update: February 20, 2007
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3