SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

A2C9U0

- SYL_PROM3

UniProt

A2C9U0 - SYL_PROM3

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Leucine--tRNA ligase

Gene
leuS, P9303_15061
Organism
Prochlorococcus marinus (strain MIT 9303)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei633 – 6331ATP By similarity

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMAR59922:GH54-1596-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligase (EC:6.1.1.4)
Alternative name(s):
Leucyl-tRNA synthetase
Short name:
LeuRS
Gene namesi
Name:leuS
Ordered Locus Names:P9303_15061
OrganismiProchlorococcus marinus (strain MIT 9303)
Taxonomic identifieri59922 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaProchloralesProchlorococcaceaeProchlorococcus
ProteomesiUP000002274: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 878878Leucine--tRNA ligaseUniRule annotationPRO_1000009393Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi59922.P9303_15061.

Structurei

3D structure databases

ProteinModelPortaliA2C9U0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi56 – 6611"HIGH" regionUniRule annotationAdd
BLAST
Motifi630 – 6345"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A2C9U0-1 [UniParc]FASTAAdd to Basket

« Hide

MTESFPSTSA SSHSSARYDP IELETRWQKE WLRQGLDRTP VAETNQKRFY    50
ALSMFPYPSG KLHMGHVRNY VITDVIARVQ RMRGDAVLHP MGWDAFGLPA 100
ENAAIARNVD PGDWTDQNIA QMRAQLDRLG LSIDWDRQQA TCHQDYYRWT 150
QWLFLELFAG GLAYQKEATV NWDPIDKTVL ANEQVDGEGR SWRSGALVEQ 200
RQLKQWFLRI TDYADALIDD LDELTGWPER VRTMQANWIG RSHGAEIKFR 250
VAGQTNSIIT VFTTRPDTLH GASYVVLAPE HPLVEALTSP QQRIAVTAFC 300
DLISQLSVKD RTAEDQPKRG VPIGAQVINP VNGESLPVWI ADYVLADYGS 350
GAVMGVPAHD ERDFIFARSH ELPIRIVVQM PDSDEHHNDG QAWTGAGVLV 400
NSGAFDGLST EEGKVAITTH GASKGWAQSK VQYRLRDWLI SRQRYWGCPI 450
PIIHCASCGI VPVPQEDLPV TLPRDIDLSG KGGSPLAQEQ DWVEVKCPIC 500
GEKAHRETDT MDTFMCSSWY YLRFADPLNS QRPFDKDIVD EWLPVDQYVG 550
GIEHAILHLL YARFFTKALH DRNLIGFKEP FNTLLTQGMV QGLTYRNTKN 600
GSYISPELVS DEGDPRDPES GDKLEILFEK MSKSKYNGVD PAVVIDRYGA 650
DTARMFILFK APPEKDLEWD DADVEGQFRF LQRLIRLIDS FVWPKTDEDN 700
ASISSANLTI SSADLSEEEI NMRRATHMAI EAITEDLSGD IQLNTAISEL 750
MKLSNSLGGK LDKVRTEVAA EALSVLVRLM APFAPHLAEE FWMKLHGQGS 800
IHQQSWPIID PSALVLETIE LVIQVKGKVR GTIQVPANAD KTALEELALK 850
SDIAVKWLEG QSPRRVIIVP GKLVNLVP 878
Length:878
Mass (Da):98,546
Last modified:February 20, 2007 - v1
Checksum:iD9528F8690422D93
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM78250.1.
RefSeqiWP_011826143.1. NC_008820.1.
YP_001017515.1. NC_008820.1.

Genome annotation databases

EnsemblBacteriaiABM78250; ABM78250; P9303_15061.
GeneIDi4777973.
KEGGipmf:P9303_15061.
PATRICi23000490. VBIProMar17757_1556.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000554 Genomic DNA. Translation: ABM78250.1 .
RefSeqi WP_011826143.1. NC_008820.1.
YP_001017515.1. NC_008820.1.

3D structure databases

ProteinModelPortali A2C9U0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 59922.P9303_15061.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABM78250 ; ABM78250 ; P9303_15061 .
GeneIDi 4777973.
KEGGi pmf:P9303_15061.
PATRICi 23000490. VBIProMar17757_1556.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci PMAR59922:GH54-1596-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MIT 9303.

Entry informationi

Entry nameiSYL_PROM3
AccessioniPrimary (citable) accession number: A2C9U0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: February 20, 2007
Last modified: September 3, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi